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• W4380291934 abstract "PGC7 and YY1 interaction inhibits recruitment of PRC2 by YY1. PGC7 promotes AKT and EZH2 interaction to increase pEZH2-S21 level, which weakens YY1 and EZH2 interaction, thereby decreasing H3K27me3 level. In zygotes, the PGC7-deficient and AKT inhibitor MK2206 promote EZH2 to enter the pronuclei, and increase H3K27me3 level in the pronuclei, as well as inhibition of the expression of zygote-activating genes regulated by H3K27me3 in two-cell embryos, which ultimately affects early embryo development." @default.
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• W4380291934 date "2023-07-01" @default.
• W4380291934 modified "2023-09-23" @default.
• W4380291934 title "PGC7 regulates H3K27me3 modification by inhibiting the interaction of YY1 with PRC2" @default.
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• W4380291934 doi "https://doi.org/10.1152/ajpcell.00041.2023" @default.
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