Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380300763> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4380300763 endingPage "109677" @default.
- W4380300763 startingPage "109677" @default.
- W4380300763 abstract "Eblasakimab is a first-in-class monoclonal antibody under investigation for the treatment of atopic dermatitis (AD), which targets IL-13Rα1, a subunit of the Type 2 receptor complex. IL-13Rα1 stimulates phosphorylation of signal transducer and activator of transcription 6 (STAT6) to drive inflammation. This brief report investigates the mechanistic basis of eblasakimab and its effects on IL-13Rα1 signaling as part of a phase 1a, open-label, single ascending dose study. Single ascending doses of eblasakimab were administered by intravenous or subcutaneous injection to healthy male volunteers. The impact of eblasakimab on IL-13Rα1 receptor occupancy and STAT6 phosphorylation was assessed in participant blood monocytes. No serious treatment emergent adverse events were reported. Eblasakimab effectively blocked the IL-13Rα1 receptor and inhibited STAT6 phosphorylation with single doses of 3 mg/kg intravenously and 300 mg subcutaneously. Results support further clinical development of eblasakimab as a novel biologic for AD, with potential for 2- to 4-week dosing regimens." @default.
- W4380300763 created "2023-06-13" @default.
- W4380300763 creator A5038026904 @default.
- W4380300763 creator A5055643756 @default.
- W4380300763 creator A5083769286 @default.
- W4380300763 creator A5086154478 @default.
- W4380300763 date "2023-08-01" @default.
- W4380300763 modified "2023-10-14" @default.
- W4380300763 title "Eblasakimab, a novel IL-13 receptor alpha 1 monoclonal antibody, blocks STAT6 phosphorylation with low dose in human volunteers" @default.
- W4380300763 cites W1882823390 @default.
- W4380300763 cites W1991631260 @default.
- W4380300763 cites W2047081723 @default.
- W4380300763 cites W2067361459 @default.
- W4380300763 cites W2070297069 @default.
- W4380300763 cites W2085177202 @default.
- W4380300763 cites W2093730193 @default.
- W4380300763 cites W2104662295 @default.
- W4380300763 cites W2129249696 @default.
- W4380300763 cites W2132665714 @default.
- W4380300763 cites W2162666912 @default.
- W4380300763 cites W2167829087 @default.
- W4380300763 cites W2728093281 @default.
- W4380300763 cites W2783829013 @default.
- W4380300763 cites W2806376977 @default.
- W4380300763 cites W2949577304 @default.
- W4380300763 cites W2991678001 @default.
- W4380300763 cites W3005823229 @default.
- W4380300763 cites W3008661668 @default.
- W4380300763 cites W3091046625 @default.
- W4380300763 cites W3162876191 @default.
- W4380300763 cites W4210392493 @default.
- W4380300763 cites W4214696217 @default.
- W4380300763 cites W4225303623 @default.
- W4380300763 cites W4281641646 @default.
- W4380300763 cites W642101920 @default.
- W4380300763 doi "https://doi.org/10.1016/j.clim.2023.109677" @default.
- W4380300763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37315681" @default.
- W4380300763 hasPublicationYear "2023" @default.
- W4380300763 type Work @default.
- W4380300763 citedByCount "0" @default.
- W4380300763 crossrefType "journal-article" @default.
- W4380300763 hasAuthorship W4380300763A5038026904 @default.
- W4380300763 hasAuthorship W4380300763A5055643756 @default.
- W4380300763 hasAuthorship W4380300763A5083769286 @default.
- W4380300763 hasAuthorship W4380300763A5086154478 @default.
- W4380300763 hasBestOaLocation W43803007631 @default.
- W4380300763 hasConcept C11960822 @default.
- W4380300763 hasConcept C126322002 @default.
- W4380300763 hasConcept C145430368 @default.
- W4380300763 hasConcept C159654299 @default.
- W4380300763 hasConcept C170493617 @default.
- W4380300763 hasConcept C171958077 @default.
- W4380300763 hasConcept C185592680 @default.
- W4380300763 hasConcept C191732599 @default.
- W4380300763 hasConcept C197934379 @default.
- W4380300763 hasConcept C203014093 @default.
- W4380300763 hasConcept C2778923194 @default.
- W4380300763 hasConcept C542903549 @default.
- W4380300763 hasConcept C55493867 @default.
- W4380300763 hasConcept C62478195 @default.
- W4380300763 hasConcept C71924100 @default.
- W4380300763 hasConcept C8891405 @default.
- W4380300763 hasConcept C98274493 @default.
- W4380300763 hasConceptScore W4380300763C11960822 @default.
- W4380300763 hasConceptScore W4380300763C126322002 @default.
- W4380300763 hasConceptScore W4380300763C145430368 @default.
- W4380300763 hasConceptScore W4380300763C159654299 @default.
- W4380300763 hasConceptScore W4380300763C170493617 @default.
- W4380300763 hasConceptScore W4380300763C171958077 @default.
- W4380300763 hasConceptScore W4380300763C185592680 @default.
- W4380300763 hasConceptScore W4380300763C191732599 @default.
- W4380300763 hasConceptScore W4380300763C197934379 @default.
- W4380300763 hasConceptScore W4380300763C203014093 @default.
- W4380300763 hasConceptScore W4380300763C2778923194 @default.
- W4380300763 hasConceptScore W4380300763C542903549 @default.
- W4380300763 hasConceptScore W4380300763C55493867 @default.
- W4380300763 hasConceptScore W4380300763C62478195 @default.
- W4380300763 hasConceptScore W4380300763C71924100 @default.
- W4380300763 hasConceptScore W4380300763C8891405 @default.
- W4380300763 hasConceptScore W4380300763C98274493 @default.
- W4380300763 hasLocation W43803007631 @default.
- W4380300763 hasLocation W43803007632 @default.
- W4380300763 hasOpenAccess W4380300763 @default.
- W4380300763 hasPrimaryLocation W43803007631 @default.
- W4380300763 hasRelatedWork W1968968766 @default.
- W4380300763 hasRelatedWork W1975999653 @default.
- W4380300763 hasRelatedWork W1990725947 @default.
- W4380300763 hasRelatedWork W2040314458 @default.
- W4380300763 hasRelatedWork W2054334194 @default.
- W4380300763 hasRelatedWork W2104361518 @default.
- W4380300763 hasRelatedWork W2143937011 @default.
- W4380300763 hasRelatedWork W290630341 @default.
- W4380300763 hasRelatedWork W3167657606 @default.
- W4380300763 hasRelatedWork W4318586843 @default.
- W4380300763 hasVolume "253" @default.
- W4380300763 isParatext "false" @default.
- W4380300763 isRetracted "false" @default.
- W4380300763 workType "article" @default.