Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380319753> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4380319753 endingPage "6" @default.
- W4380319753 startingPage "6" @default.
- W4380319753 abstract "Background: In cardiogenic shock (CS), the hemodynamic profile of obesity and requirement for hemodynamic support based on body mass index (BMI) is not well studied. We aimed to explore the hemodynamic characteristics and vasopressor/inotrope/mechanical circulatory support (MCS) requirements across the BMI spectrum. Methods: The Cardiogenic Shock Working Group (CSWG) registry includes patients with CS from 17 clinical sites across the USA. We stratified the participants into BMI quartiles, from 1 to 4, as follows: BMI≤24.4 kg/m2, 24.4<BMI≤28.3 kg/m2, 28.3<BMI≤33.1 kg/m2, and BMI>33.1 kg/m2. We then compared hemodynamic variables and utilization of vasopressors/inotropes and MCS across the strata. Results: A total of the 3,492 patients with known BMI were included. While the heart rate was similar across the quartiles, both systemic blood pressure and filling cardiac pressures increased from lower to higher BMI quartiles. Cardiac output also increased, cardiac index did not change, and pulmonary artery pulsatility index (PAPI) decreased as the BMI was increasing (Table). The requirements in pharmacological hemodynamic support was also higher in obese individual. The proportion of patients, requiring two and more vasopressor/inotropic agents, increased from 12.1% in the lowest quartile to 19.1% in the highest quartile, p<0.0001. At the same time, device utilization, including intraaortic balloon pump, Impella, and venoarterial extracorporeal membrane oxygenation (VA ECMO), and the combination of the above, remained similar across the subsets. Conclusions: In cardiogenic shock, the hemodynamic profile differs based on BMI. Obese patients have highest systolic and mean blood pressure, cardiac output, pulmonary arterial pressure, and filling pressures. At the same time, they demonstrate the lowest pulmonary artery pulsatility index. More obese individuals have higher requirements in pharmacological support (Vasopressors/inotropes). The use of MCS is similar across the BMI quartiles." @default.
- W4380319753 created "2023-06-13" @default.
- W4380319753 creator A5000653485 @default.
- W4380319753 creator A5005347770 @default.
- W4380319753 creator A5008709171 @default.
- W4380319753 creator A5015999831 @default.
- W4380319753 creator A5026735321 @default.
- W4380319753 creator A5048484659 @default.
- W4380319753 creator A5069436790 @default.
- W4380319753 creator A5074546182 @default.
- W4380319753 date "2023-06-01" @default.
- W4380319753 modified "2023-09-26" @default.
- W4380319753 title "TOP8: Pharmacological and Mechanical Circulatory Support in Cardiogenic Shock: Does Obesity Put the Patients at Disadvantage?" @default.
- W4380319753 doi "https://doi.org/10.1097/01.mat.0000943288.19658.bf" @default.
- W4380319753 hasPublicationYear "2023" @default.
- W4380319753 type Work @default.
- W4380319753 citedByCount "0" @default.
- W4380319753 crossrefType "journal-article" @default.
- W4380319753 hasAuthorship W4380319753A5000653485 @default.
- W4380319753 hasAuthorship W4380319753A5005347770 @default.
- W4380319753 hasAuthorship W4380319753A5008709171 @default.
- W4380319753 hasAuthorship W4380319753A5015999831 @default.
- W4380319753 hasAuthorship W4380319753A5026735321 @default.
- W4380319753 hasAuthorship W4380319753A5048484659 @default.
- W4380319753 hasAuthorship W4380319753A5069436790 @default.
- W4380319753 hasAuthorship W4380319753A5074546182 @default.
- W4380319753 hasBestOaLocation W43803197531 @default.
- W4380319753 hasConcept C126322002 @default.
- W4380319753 hasConcept C139940330 @default.
- W4380319753 hasConcept C155710745 @default.
- W4380319753 hasConcept C164705383 @default.
- W4380319753 hasConcept C178853913 @default.
- W4380319753 hasConcept C2776850375 @default.
- W4380319753 hasConcept C2780221984 @default.
- W4380319753 hasConcept C2781300812 @default.
- W4380319753 hasConcept C31861589 @default.
- W4380319753 hasConcept C42219234 @default.
- W4380319753 hasConcept C44249647 @default.
- W4380319753 hasConcept C500558357 @default.
- W4380319753 hasConcept C68443243 @default.
- W4380319753 hasConcept C71924100 @default.
- W4380319753 hasConceptScore W4380319753C126322002 @default.
- W4380319753 hasConceptScore W4380319753C139940330 @default.
- W4380319753 hasConceptScore W4380319753C155710745 @default.
- W4380319753 hasConceptScore W4380319753C164705383 @default.
- W4380319753 hasConceptScore W4380319753C178853913 @default.
- W4380319753 hasConceptScore W4380319753C2776850375 @default.
- W4380319753 hasConceptScore W4380319753C2780221984 @default.
- W4380319753 hasConceptScore W4380319753C2781300812 @default.
- W4380319753 hasConceptScore W4380319753C31861589 @default.
- W4380319753 hasConceptScore W4380319753C42219234 @default.
- W4380319753 hasConceptScore W4380319753C44249647 @default.
- W4380319753 hasConceptScore W4380319753C500558357 @default.
- W4380319753 hasConceptScore W4380319753C68443243 @default.
- W4380319753 hasConceptScore W4380319753C71924100 @default.
- W4380319753 hasIssue "Supplement 2" @default.
- W4380319753 hasLocation W43803197531 @default.
- W4380319753 hasLocation W43803197532 @default.
- W4380319753 hasOpenAccess W4380319753 @default.
- W4380319753 hasPrimaryLocation W43803197531 @default.
- W4380319753 hasRelatedWork W1973163757 @default.
- W4380319753 hasRelatedWork W2028209775 @default.
- W4380319753 hasRelatedWork W2074088163 @default.
- W4380319753 hasRelatedWork W2184287961 @default.
- W4380319753 hasRelatedWork W2351825238 @default.
- W4380319753 hasRelatedWork W2409811433 @default.
- W4380319753 hasRelatedWork W2419750755 @default.
- W4380319753 hasRelatedWork W2475327391 @default.
- W4380319753 hasRelatedWork W2739633163 @default.
- W4380319753 hasRelatedWork W2125905047 @default.
- W4380319753 hasVolume "69" @default.
- W4380319753 isParatext "false" @default.
- W4380319753 isRetracted "false" @default.
- W4380319753 workType "article" @default.