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- W4380320110 abstract "Abstract Background High glycaemic index (GI) foods can lead to negative health outcomes such as glucose spikes, insulin resistance, weight gain, and glucose crashes. Glubloc™ is a proprietary plant extract blend of Morus alba L and Malus domestica rind, enriched with polyphenolic flavonoids that inhibits enzymes responsible for carbohydrate digestion and glucose absorption and has shown potential in modulating blood sugar surge post-meal intake. Objective This study was aimed to investigate the impact of Glubloc™ on postprandial glucose response (PPGR) in healthy individuals after consuming a high GI meal (300g cooked rice) or a sucrose drink (70g table sugar dissolved in 400ml water). Design: Two studies were conducted using a placebo-controlled design. Subjects (n = 40 for rice meal study, n = 40 for sucrose drink study) received either placebo or Glubloc™ (500mg) before the meal/drink. Blood glucose levels were measured at various time points up to 180 minutes for the rice meal study and 120 minutes for the sucrose drink study. Results Glubloc™ supplementation significantly reduced PPGR in both the rice meal study and sucrose drink study. Compared to the placebo group, Glubloc™ resulted in significantly lower incremental area under the curve (iAUC) values for glucose levels (1063 mg/dL × min vs. 5090 mg/dL × min for rice meal; 859 mg/dL × min vs. 2266 mg/dL × min for sucrose drink). No adverse events were reported. Conclusions Glubloc™ supplementation effectively reduced postprandial glucose response in healthy individuals consuming high GI meals or sucrose drinks. It demonstrated potential as a safe and effective means to modulate blood glucose levels, thereby minimizing the negative effects of glucose and insulin spikes associated with high GI foods. Glubloc™ could be a valuable supplement for individuals seeking to manage their blood glucose levels after consuming carbohydrate-rich meals or sugary beverages. Further research is warranted to explore its broader applications in managing metabolic conditions." @default.
- W4380320110 created "2023-06-13" @default.
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- W4380320110 date "2023-06-12" @default.
- W4380320110 modified "2023-09-25" @default.
- W4380320110 title "Glubloc™ Reduces Postprandial Blood Glucose Surge in Healthy Individuals (A Placebo Controlled Pilot study)." @default.
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- W4380320110 doi "https://doi.org/10.21203/rs.3.rs-3038659/v2" @default.
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