Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380320194> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4380320194 endingPage "110" @default.
- W4380320194 startingPage "110" @default.
- W4380320194 abstract "A sorbent with high enough capacity for NH4+ could serve as an oral binder to lower urea levels in end-stage kidney disease patients (Figure 1). A hydrogen-loaded cation exchanger such as zirconium phosphate (ZrP) is a promising candidate for this application. However, the NH4+ binding selectivity versus other ions must be improved. A gas-permeable and hydrophobic surface coating was first attached to an amorphous form of ZrP using tetraethyl orthosilicate and methoxy-terminated polydimethylsiloxane (PDMS). The coating prevents ions in solution from reaching the ion-exchanger but allows NH3 transfer to the ZrP. The selectivity of the coating was measured with NH4+ and Ca2+ solutions versus uncoated ZrP. X-ray photoelectron spectroscopy and scanning electron microscopy measurements showed the coating successfully modified the surface of ZrP. Water contact angle (WCA) studies indicated coated ZrP was hydrophobic (149.8° ± 2.5°). The in vitro studies showed coated ZrP removed 94% (± 11%) more NH4+ than uncoated ZrP in the presence of Ca2+. And Ca2+ binding decreased by 64% (± 6%). The increase in NH4+ selectivity was due to the applied coating. But the material’s selectivity decreased by 72% after exposure to stomach acid conditions. An alternative hydrophobic (WCA = 145.0° ± 3.2°) and gas permeable coating was investigated – perfluorooctyltriethoxysilane (FOTS). The coating was attached to a polysiloxane membrane on ZrP’s surface. In vitro studies in Figure 2b indicated the FOTS structure attached to ZrP offers complete selectivity for NH4+ over Ca2+ with similar NH4+ capacity as the PDMS coating. FOTS-coated ZrP maintained its selectivity and NH4+ removal capacity after stomach acid exposure. The results indicate FOTS-coated ZrP could work as an oral sorbent for ESKD patients.Figure 1. The recirculation of urea and oral sorbent’s methodology for NH4+ adsorption. Figure has been adapted from Barret’s original artwork.1Figure 2. (a): SEM images of uncoated, PDMS-coated and FOTS-coated ZrP at 10,000x magnification. (b): Binding study results of uncoated, PDMS-coated and FOTS-coated ZrP." @default.
- W4380320194 created "2023-06-13" @default.
- W4380320194 creator A5002727567 @default.
- W4380320194 creator A5089963460 @default.
- W4380320194 date "2023-06-01" @default.
- W4380320194 modified "2023-09-26" @default.
- W4380320194 title "P8: A Coated ZrP Cation Exchanger with Excellent Ammonium Selectivity and Chemical Stability: An Oral Sorbent for End-Stage Kidney Disease (ESKD)" @default.
- W4380320194 doi "https://doi.org/10.1097/01.mat.0000943856.38670.2c" @default.
- W4380320194 hasPublicationYear "2023" @default.
- W4380320194 type Work @default.
- W4380320194 citedByCount "0" @default.
- W4380320194 crossrefType "journal-article" @default.
- W4380320194 hasAuthorship W4380320194A5002727567 @default.
- W4380320194 hasAuthorship W4380320194A5089963460 @default.
- W4380320194 hasBestOaLocation W43803201941 @default.
- W4380320194 hasConcept C118792377 @default.
- W4380320194 hasConcept C127413603 @default.
- W4380320194 hasConcept C13965031 @default.
- W4380320194 hasConcept C159985019 @default.
- W4380320194 hasConcept C161790260 @default.
- W4380320194 hasConcept C178790620 @default.
- W4380320194 hasConcept C185592680 @default.
- W4380320194 hasConcept C192562407 @default.
- W4380320194 hasConcept C2781448156 @default.
- W4380320194 hasConcept C42360764 @default.
- W4380320194 hasConcept C6556556 @default.
- W4380320194 hasConceptScore W4380320194C118792377 @default.
- W4380320194 hasConceptScore W4380320194C127413603 @default.
- W4380320194 hasConceptScore W4380320194C13965031 @default.
- W4380320194 hasConceptScore W4380320194C159985019 @default.
- W4380320194 hasConceptScore W4380320194C161790260 @default.
- W4380320194 hasConceptScore W4380320194C178790620 @default.
- W4380320194 hasConceptScore W4380320194C185592680 @default.
- W4380320194 hasConceptScore W4380320194C192562407 @default.
- W4380320194 hasConceptScore W4380320194C2781448156 @default.
- W4380320194 hasConceptScore W4380320194C42360764 @default.
- W4380320194 hasConceptScore W4380320194C6556556 @default.
- W4380320194 hasIssue "Supplement 2" @default.
- W4380320194 hasLocation W43803201941 @default.
- W4380320194 hasLocation W43803201942 @default.
- W4380320194 hasOpenAccess W4380320194 @default.
- W4380320194 hasPrimaryLocation W43803201941 @default.
- W4380320194 hasRelatedWork W2588032369 @default.
- W4380320194 hasRelatedWork W2590572658 @default.
- W4380320194 hasRelatedWork W2738001763 @default.
- W4380320194 hasRelatedWork W2748952813 @default.
- W4380320194 hasRelatedWork W2899084033 @default.
- W4380320194 hasRelatedWork W2950426465 @default.
- W4380320194 hasRelatedWork W3094722505 @default.
- W4380320194 hasRelatedWork W3117315990 @default.
- W4380320194 hasRelatedWork W4323322376 @default.
- W4380320194 hasRelatedWork W4383893806 @default.
- W4380320194 hasVolume "69" @default.
- W4380320194 isParatext "false" @default.
- W4380320194 isRetracted "false" @default.
- W4380320194 workType "article" @default.