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• W4380322214 abstract "Abstract Background The diaphragm function assessed by ultrasound has been well-studied in COPD, asthma, and intensive care. However, there are only a few studies on diffuse interstitial lung disease, while dyspnea and quality of life are major issues in the management that may depend on the diaphragm. Methods We retrospectively included idiopathic pulmonary fibrosis (IPF) patients followed in our center (Marseille, France) between January 2020 and February 2023 who underwent diaphragmatic ultrasound. Our objectives were to describe the diaphragmatic function of IPFs compared to healthy controls and to correlate with clinical, functional, and lung density on CT-scan. Results 24 IPF patients and 157 controls were included. The diaphragmatic amplitude in IPF was increased at rest (median of 2.20cm vs 1.88cm on the right, p < 0.007, and 2.30cm vs 1.91cm on the left, p < 0.03, in IPF and controls respectively) and decreased in deep breathing (median of 4.85cm vs 5.45cm on the right, p < 0.009, and 5.10cm vs 5.65cm on the left, p < 0.046, in IPF and controls respectively). Diaphragmatic thickness was significantly reduced at rest on the right side (median of 1.75mm vs 2.00mm, p < 0.02, in IPF and controls respectively) and in deep breathing on both sides compared to controls (mean of 3.82mm vs 4.15mm on the right, p < 0.02, and 3.53mm vs 3.94mm, on the left, p < 0.009, in IPF and controls respectively). Diaphragmatic amplitude in deep breathing was moderate to strongly correlated with FVC, DLCO, and 6MWT and negatively correlated with the dyspnea and lung density on CT scan. Discussion The diaphragmatic amplitude and thickness were impaired in IPF compared to controls. Diaphragmatic amplitude is the parameter best correlated with clinical, functional, and lung density criteria. Further studies are needed to determine if diaphragmatic amplitude can be a prognostic factor in IPF. Trial Registration: CEPRO 2022-033bis, 08/11/2022, retrospectively registered" @default.
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• W4380322214 date "2023-06-12" @default.
• W4380322214 modified "2023-09-25" @default.
• W4380322214 title "Ultrasound evaluation of diaphragmatic function in patients with idiopathic pulmonary fibrosis: a retrospective observational study" @default.
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• W4380322214 doi "https://doi.org/10.21203/rs.3.rs-3036042/v1" @default.
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