FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380344552> ?p ?o ?g. }

• W4380344552 endingPage "152056" @default.
• W4380344552 startingPage "152056" @default.
• W4380344552 abstract "The current study was intended to evaluate impacts of both iron (Fe) enrichment and overload (in the form of ferrous sulphate heptahydrate, FeSO4.7H2O) on ultrastructural characteristics of human adrenocarcinoma NCI-H295R cell line. Here, the NCI-H295R cells were treated with 0, 3.90, and 1000 µM FeSO40.7 H2O, and consequently proceeded for purposes of ultrastructural studies. Micrographs taken under transmission electron microscope (TEM) were investigated from the qualitative and quantitative (unbiased stereological approaches) aspects, and obtained findings were compared among the three groups of the cells. The ultrastructural features related to the steroidogenic process were found to be similar between the untreated and both Fe-exposed cell populations, with conspicuous mitochondria with well-defined lamellar cristae (creating clusters of varying sizes in the regions of increased energy demands) and concentric whorls of smooth endoplasmic reticulum (SER) being the most noticeable characteristics. The precise estimates of the component (volume, surface) fractions of the nucleus, mitochondria, and lipid droplets (LDs), as well as of the nucleus/cytoplasm (N/C) ratio have revealed close similarities (P > 0.05) in all cell groups investigated. Nonetheless, the low concentration of FeSO4.7H2O exhibited beneficial action on ultrastructural organization of the NCI-H295R cells. In effect, these cells were distinguished by mitochondria with smoother surfaces and clearer outlines, higher density of thin, parallel lamellar cristae (deeply extending into the mitochondrial matrix), and more widespread distribution of fine SER tubules as compared to the control ones, all of them suggesting higher level of energy requirements and metabolic activity, and more intensive rate of steroidogenesis. Interestingly, no obvious ultrastructural modifications were observed in the NCI-H295R cells treated with high FeSO4.7H2O concentration. This finding can be linked to either an adaptive ultrastructural machinery of these cells to cope with the adverse effect of the element or to insufficient dose of FeSO40.7 H2O (1000 µM) to induce ultrastructural signs of cytotoxicity. Purposefully, the results of the current study complement our previous paper dealing with impacts of FeSO4.7H2O on the NCI-H295R cell viability and steroidogenesis at the molecular level. Hence, they fill a knowledge gap considering structure-function coupling in this cellular model system upon the metal exposure. This integrated approach can enhance our understanding of the cellular responses to Fe enrichment and overload which can be helpful for individuals with reproductive health concerns." @default.
• W4380344552 created "2023-06-13" @default.
• W4380344552 creator A5002317729 @default.
• W4380344552 creator A5006836774 @default.
• W4380344552 creator A5017839123 @default.
• W4380344552 creator A5019656677 @default.
• W4380344552 creator A5024400680 @default.
• W4380344552 creator A5080152762 @default.
• W4380344552 creator A5091126306 @default.
• W4380344552 date "2023-08-01" @default.
• W4380344552 modified "2023-09-22" @default.
• W4380344552 title "Impacts of iron on ultrastructural features of NCI-H295R cell line related to steroidogenesis" @default.
• W4380344552 cites W170154559 @default.
• W4380344552 cites W1819141033 @default.
• W4380344552 cites W1967947686 @default.
• W4380344552 cites W1973925794 @default.
• W4380344552 cites W1987402259 @default.
• W4380344552 cites W2000244701 @default.
• W4380344552 cites W2000801338 @default.
• W4380344552 cites W2003431931 @default.
• W4380344552 cites W2009171847 @default.
• W4380344552 cites W2012094973 @default.
• W4380344552 cites W2018171488 @default.
• W4380344552 cites W2022154319 @default.
• W4380344552 cites W2031348353 @default.
• W4380344552 cites W2034239471 @default.
• W4380344552 cites W2034843477 @default.
• W4380344552 cites W2039223391 @default.
• W4380344552 cites W2059275346 @default.
• W4380344552 cites W2060293139 @default.
• W4380344552 cites W2064502593 @default.
• W4380344552 cites W2080629728 @default.
• W4380344552 cites W2085893622 @default.
• W4380344552 cites W2090317433 @default.
• W4380344552 cites W2097221267 @default.
• W4380344552 cites W2108356796 @default.
• W4380344552 cites W2121212302 @default.
• W4380344552 cites W2125145074 @default.
• W4380344552 cites W2132867511 @default.
• W4380344552 cites W2133314499 @default.
• W4380344552 cites W2142741326 @default.
• W4380344552 cites W2145354163 @default.
• W4380344552 cites W2158115535 @default.
• W4380344552 cites W2159727241 @default.
• W4380344552 cites W2233460772 @default.
• W4380344552 cites W2275201610 @default.
• W4380344552 cites W2275305908 @default.
• W4380344552 cites W2312886949 @default.
• W4380344552 cites W2316788075 @default.
• W4380344552 cites W2480216102 @default.
• W4380344552 cites W2559410759 @default.
• W4380344552 cites W2586320694 @default.
• W4380344552 cites W2605676498 @default.
• W4380344552 cites W2696341497 @default.
• W4380344552 cites W2763353102 @default.
• W4380344552 cites W2789973813 @default.
• W4380344552 cites W2800364130 @default.
• W4380344552 cites W2802286032 @default.
• W4380344552 cites W2891634759 @default.
• W4380344552 cites W2903058414 @default.
• W4380344552 cites W2952590352 @default.
• W4380344552 cites W2955640465 @default.
• W4380344552 cites W2958576964 @default.
• W4380344552 cites W2966770752 @default.
• W4380344552 cites W2971048027 @default.
• W4380344552 cites W2992534266 @default.
• W4380344552 cites W3012744513 @default.
• W4380344552 cites W3015635259 @default.
• W4380344552 cites W3043860810 @default.
• W4380344552 cites W3080780310 @default.
• W4380344552 cites W3095973159 @default.
• W4380344552 cites W3126094309 @default.
• W4380344552 cites W3135632400 @default.
• W4380344552 cites W3165521277 @default.
• W4380344552 cites W3207488059 @default.
• W4380344552 cites W3210275834 @default.
• W4380344552 cites W4213415126 @default.
• W4380344552 cites W4220875331 @default.
• W4380344552 cites W4220888526 @default.
• W4380344552 cites W4220902000 @default.
• W4380344552 cites W4220910464 @default.
• W4380344552 cites W4280515492 @default.
• W4380344552 cites W4281620153 @default.
• W4380344552 cites W4281681311 @default.
• W4380344552 cites W4283802388 @default.
• W4380344552 cites W4294740955 @default.
• W4380344552 cites W4310135780 @default.
• W4380344552 cites W4313898565 @default.
• W4380344552 doi "https://doi.org/10.1016/j.acthis.2023.152056" @default.
• W4380344552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37321134" @default.
• W4380344552 hasPublicationYear "2023" @default.
• W4380344552 type Work @default.
• W4380344552 citedByCount "0" @default.
• W4380344552 crossrefType "journal-article" @default.
• W4380344552 hasAuthorship W4380344552A5002317729 @default.
• W4380344552 hasAuthorship W4380344552A5006836774 @default.
• W4380344552 hasAuthorship W4380344552A5017839123 @default.
• W4380344552 hasAuthorship W4380344552A5019656677 @default.

• next