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- W4380355440 abstract "The shape of the epithelial monolayer can be depicted as a curved tissue in three-dimensional (3D) space, where individual cells are tightly adhered to one another. The 3D morphogenesis of these tissues is governed by cell dynamics, and a variety of mathematical modeling and simulation studies have been conducted to investigate this process. One promising approach is the cell-center model, which can account for the discreteness of cells. The cell nucleus, which is considered to correspond to the cell center, can be observed experimentally. However, there has been a shortage of cell-center models specifically tailored for simulating 3D monolayer tissue deformation. In this study, we developed a mathematical model based on the cell-center model to simulate 3D monolayer tissue deformation. Our model was confirmed by simulating the in-plane deformation, out-of-plane deformation, and invagination due to apical constriction." @default.
- W4380355440 created "2023-06-13" @default.
- W4380355440 creator A5024222736 @default.
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- W4380355440 date "2023-08-01" @default.
- W4380355440 modified "2023-09-25" @default.
- W4380355440 title "Cell-center-based model for simulating three-dimensional monolayer tissue deformation" @default.
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- W4380355440 doi "https://doi.org/10.1016/j.jtbi.2023.111560" @default.
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