FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380358510> ?p ?o ?g. }

• W4380358510 endingPage "256" @default.
• W4380358510 startingPage "243" @default.
• W4380358510 abstract "Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are closely related diseases associated with smoking history and dysregulated immune response. However, not all smokers develop the disease, indicating that genetic susceptibility could be important. Therefore, the aim of this study was to search for the potential overlapping genetic biomarkers, with a focus on single nucleotide polymorphisms (SNPs) located in the regulatory regions of immune-related genes. Additionally, the aim was to see if an identified SNP has potentially an effect on proinflamma-tory cytokine concentration in the serum of COPD patients. We extracted summary data of variants in 1511 immune-related genes from COPD and LC genome-wide association studies (GWAS) from the UK Biobank. The LC data had 203 cases, patients diagnosed with LC, and 360 938 controls, while COPD data had 1 897 cases and 359 297 controls. Assuming 1 association/gene, SNPs with a p-value < 3.3 × 10-5 were considered statistically significantly associated with the disease. We identified seven SNPs located in different genes (BAG6, BTNL2, TNF, HCP5, MICB, NCR3, ABCF1, TCF7L1) to be associated with the COPD risk and two with the LC risk (HLA-C, HLA-B), with statistical significance. We also identified two SNPs located in the IL2RA gene associated with LC (rs2386841; p = 1.86 × 10-4) and COPD (rs11256442; p = 9.79 × 10-3) but with lower significance. Functional studies conducted on COPD patients showed that RNA expression of IL2RA, IFNγ and related proinflammatory cytokines in blood serum did not correlate with a specific genotype. Although results presented in this study do not fully support our hypothesis, it is worth to mention that the identified genes/SNPs that were associated with either COPD or LC risk, all were involved in the activation of the NF-κB transcription factor which is closely related to the regulation of the inflammatory response, a condition associated with both pathologies." @default.
• W4380358510 created "2023-06-13" @default.
• W4380358510 creator A5010674757 @default.
• W4380358510 creator A5017796230 @default.
• W4380358510 creator A5019402803 @default.
• W4380358510 creator A5029188076 @default.
• W4380358510 creator A5036823553 @default.
• W4380358510 creator A5043895758 @default.
• W4380358510 creator A5045353016 @default.
• W4380358510 creator A5067061017 @default.
• W4380358510 creator A5090445568 @default.
• W4380358510 creator A5092146397 @default.
• W4380358510 date "2023-06-01" @default.
• W4380358510 modified "2023-10-18" @default.
• W4380358510 title "Germline variants of the genes involved in NF-kB activation are associated with the risk of COPD and lung cancer development" @default.
• W4380358510 cites W1967869683 @default.
• W4380358510 cites W1974313653 @default.
• W4380358510 cites W1983074899 @default.
• W4380358510 cites W1989029893 @default.
• W4380358510 cites W1990948095 @default.
• W4380358510 cites W1999584427 @default.
• W4380358510 cites W2001512445 @default.
• W4380358510 cites W2002955275 @default.
• W4380358510 cites W2004635533 @default.
• W4380358510 cites W2013244153 @default.
• W4380358510 cites W2014738267 @default.
• W4380358510 cites W2018161209 @default.
• W4380358510 cites W2028477927 @default.
• W4380358510 cites W2034796618 @default.
• W4380358510 cites W2039033921 @default.
• W4380358510 cites W2045616259 @default.
• W4380358510 cites W2066669827 @default.
• W4380358510 cites W2066686943 @default.
• W4380358510 cites W2082704080 @default.
• W4380358510 cites W2092496609 @default.
• W4380358510 cites W2101182707 @default.
• W4380358510 cites W2107277218 @default.
• W4380358510 cites W2108559026 @default.
• W4380358510 cites W2112509615 @default.
• W4380358510 cites W2118094114 @default.
• W4380358510 cites W2124343538 @default.
• W4380358510 cites W2131602976 @default.
• W4380358510 cites W2133656392 @default.
• W4380358510 cites W2140841968 @default.
• W4380358510 cites W2154023242 @default.
• W4380358510 cites W2154204110 @default.
• W4380358510 cites W2154270323 @default.
• W4380358510 cites W2157334646 @default.
• W4380358510 cites W2157409103 @default.
• W4380358510 cites W2160443208 @default.
• W4380358510 cites W2161357018 @default.
• W4380358510 cites W2234060878 @default.
• W4380358510 cites W2336449142 @default.
• W4380358510 cites W2724116530 @default.
• W4380358510 cites W2735527928 @default.
• W4380358510 cites W2752993654 @default.
• W4380358510 cites W2762272043 @default.
• W4380358510 cites W2767024986 @default.
• W4380358510 cites W2802045099 @default.
• W4380358510 cites W2887432525 @default.
• W4380358510 cites W2914339303 @default.
• W4380358510 cites W2955443102 @default.
• W4380358510 cites W2989549269 @default.
• W4380358510 cites W3023885707 @default.
• W4380358510 cites W3047492519 @default.
• W4380358510 cites W3085940154 @default.
• W4380358510 cites W3092230990 @default.
• W4380358510 cites W3113963435 @default.
• W4380358510 cites W3120208600 @default.
• W4380358510 cites W3135167712 @default.
• W4380358510 cites W3198294547 @default.
• W4380358510 cites W3210387792 @default.
• W4380358510 doi "https://doi.org/10.2478/acph-2023-0019" @default.
• W4380358510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37307368" @default.
• W4380358510 hasPublicationYear "2023" @default.
• W4380358510 type Work @default.
• W4380358510 citedByCount "0" @default.
• W4380358510 crossrefType "journal-article" @default.
• W4380358510 hasAuthorship W4380358510A5010674757 @default.
• W4380358510 hasAuthorship W4380358510A5017796230 @default.
• W4380358510 hasAuthorship W4380358510A5019402803 @default.
• W4380358510 hasAuthorship W4380358510A5029188076 @default.
• W4380358510 hasAuthorship W4380358510A5036823553 @default.
• W4380358510 hasAuthorship W4380358510A5043895758 @default.
• W4380358510 hasAuthorship W4380358510A5045353016 @default.
• W4380358510 hasAuthorship W4380358510A5067061017 @default.
• W4380358510 hasAuthorship W4380358510A5090445568 @default.
• W4380358510 hasAuthorship W4380358510A5092146397 @default.
• W4380358510 hasBestOaLocation W43803585101 @default.
• W4380358510 hasConcept C104317684 @default.
• W4380358510 hasConcept C106208931 @default.
• W4380358510 hasConcept C121608353 @default.
• W4380358510 hasConcept C126322002 @default.
• W4380358510 hasConcept C135763542 @default.
• W4380358510 hasConcept C139275648 @default.
• W4380358510 hasConcept C153209595 @default.
• W4380358510 hasConcept C203014093 @default.
• W4380358510 hasConcept C2776256026 @default.

• next