Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380359483> ?p ?o ?g. }
- W4380359483 abstract "Cisplatin is commonly used to treat cervical cancer while drug resistance limits its effectiveness. There is an urgent need to identify strategies that increase cisplatin sensitivity and improve the outcomes of chemotherapy.We performed whole exome sequencing (WES) of 156 cervical cancer tissues to assess genomic features related to platinum-based chemoresistance. By using WES, we identified a frequently mutated locus SETD8 (7%), which was associated with drug sensitivity. Cell functional assays, in vivo xenografts tumor growth experiments, and survival analysis were used to investigate the functional significance and mechanism of chemosensitization after SETD8 downregulation. Knockdown of SETD8 increased the responsiveness of cervical cancer cells to cisplatin treatment. The mechanism is exerted by reduced binding of 53BP1 to DNA breaks and inhibition of the non-homologous end joining (NHEJ) repair pathway. In addition, SETD8 expression was positively correlated with resistance to cisplatin and negatively associated with the prognosis of cervical cancer patients. Further, UNC0379 as a small molecule inhibitor of SETD8 was found to enhance cisplatin sensitivity both in vitro and in vivo.SETD8 was a promising therapeutic target to ameliorate cisplatin resistance and improve the efficacy of chemotherapy." @default.
- W4380359483 created "2023-06-13" @default.
- W4380359483 creator A5004511320 @default.
- W4380359483 creator A5007899665 @default.
- W4380359483 creator A5015133365 @default.
- W4380359483 creator A5025820603 @default.
- W4380359483 creator A5039649645 @default.
- W4380359483 creator A5044569531 @default.
- W4380359483 creator A5065708983 @default.
- W4380359483 creator A5067322004 @default.
- W4380359483 creator A5081382122 @default.
- W4380359483 creator A5083567233 @default.
- W4380359483 date "2023-06-12" @default.
- W4380359483 modified "2023-10-16" @default.
- W4380359483 title "SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair" @default.
- W4380359483 cites W1528896526 @default.
- W4380359483 cites W1781764024 @default.
- W4380359483 cites W1976385056 @default.
- W4380359483 cites W1984068087 @default.
- W4380359483 cites W1996496834 @default.
- W4380359483 cites W1998734250 @default.
- W4380359483 cites W2003982140 @default.
- W4380359483 cites W2019617397 @default.
- W4380359483 cites W2023410485 @default.
- W4380359483 cites W2024634274 @default.
- W4380359483 cites W2038978453 @default.
- W4380359483 cites W2042487483 @default.
- W4380359483 cites W2049436772 @default.
- W4380359483 cites W2070460687 @default.
- W4380359483 cites W2070890790 @default.
- W4380359483 cites W2084492467 @default.
- W4380359483 cites W2096439168 @default.
- W4380359483 cites W2096791516 @default.
- W4380359483 cites W2103441770 @default.
- W4380359483 cites W2108068107 @default.
- W4380359483 cites W2110199196 @default.
- W4380359483 cites W2124733101 @default.
- W4380359483 cites W2126233883 @default.
- W4380359483 cites W2127286396 @default.
- W4380359483 cites W2130177169 @default.
- W4380359483 cites W2131178190 @default.
- W4380359483 cites W2138601221 @default.
- W4380359483 cites W2140210955 @default.
- W4380359483 cites W2145869787 @default.
- W4380359483 cites W2160981405 @default.
- W4380359483 cites W2161384666 @default.
- W4380359483 cites W2165086348 @default.
- W4380359483 cites W2168133698 @default.
- W4380359483 cites W2169492198 @default.
- W4380359483 cites W2170335587 @default.
- W4380359483 cites W2214719848 @default.
- W4380359483 cites W2414600312 @default.
- W4380359483 cites W2480089904 @default.
- W4380359483 cites W2558715006 @default.
- W4380359483 cites W2597062310 @default.
- W4380359483 cites W2602770731 @default.
- W4380359483 cites W2613362156 @default.
- W4380359483 cites W2889646458 @default.
- W4380359483 cites W2969669884 @default.
- W4380359483 cites W2980550198 @default.
- W4380359483 cites W2981289756 @default.
- W4380359483 cites W3013239365 @default.
- W4380359483 cites W3025276473 @default.
- W4380359483 cites W3047995724 @default.
- W4380359483 cites W3103763191 @default.
- W4380359483 cites W3136270220 @default.
- W4380359483 cites W3139511935 @default.
- W4380359483 cites W4200617810 @default.
- W4380359483 cites W4226214165 @default.
- W4380359483 cites W4310988851 @default.
- W4380359483 doi "https://doi.org/10.1186/s13578-023-01054-y" @default.
- W4380359483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37308924" @default.
- W4380359483 hasPublicationYear "2023" @default.
- W4380359483 type Work @default.
- W4380359483 citedByCount "0" @default.
- W4380359483 crossrefType "journal-article" @default.
- W4380359483 hasAuthorship W4380359483A5004511320 @default.
- W4380359483 hasAuthorship W4380359483A5007899665 @default.
- W4380359483 hasAuthorship W4380359483A5015133365 @default.
- W4380359483 hasAuthorship W4380359483A5025820603 @default.
- W4380359483 hasAuthorship W4380359483A5039649645 @default.
- W4380359483 hasAuthorship W4380359483A5044569531 @default.
- W4380359483 hasAuthorship W4380359483A5065708983 @default.
- W4380359483 hasAuthorship W4380359483A5067322004 @default.
- W4380359483 hasAuthorship W4380359483A5081382122 @default.
- W4380359483 hasAuthorship W4380359483A5083567233 @default.
- W4380359483 hasBestOaLocation W43803594831 @default.
- W4380359483 hasConcept C104317684 @default.
- W4380359483 hasConcept C121608353 @default.
- W4380359483 hasConcept C126322002 @default.
- W4380359483 hasConcept C134935766 @default.
- W4380359483 hasConcept C143998085 @default.
- W4380359483 hasConcept C173396325 @default.
- W4380359483 hasConcept C207001950 @default.
- W4380359483 hasConcept C2776694085 @default.
- W4380359483 hasConcept C2778220009 @default.
- W4380359483 hasConcept C2778239845 @default.
- W4380359483 hasConcept C502942594 @default.
- W4380359483 hasConcept C54355233 @default.
- W4380359483 hasConcept C71924100 @default.