Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380365298> ?p ?o ?g. }
- W4380365298 endingPage "3152" @default.
- W4380365298 startingPage "3152" @default.
- W4380365298 abstract "Cellular plasticity in cancer enables adaptation to selective pressures and stress imposed by the tumor microenvironment. This plasticity facilitates the remodeling of cancer cell phenotype and function (such as tumor stemness, metastasis, chemo/radio resistance), and the reprogramming of the surrounding tumor microenvironment to enable immune evasion. Epithelial plasticity is one form of cellular plasticity, which is intrinsically linked with epithelial-mesenchymal transition (EMT). Traditionally, EMT has been regarded as a binary state. Yet, increasing evidence suggests that EMT involves a spectrum of quasi-epithelial and quasi-mesenchymal phenotypes governed by complex interactions between cellular metabolism, transcriptome regulation, and epigenetic mechanisms. Herein, we review the complex cross-talk between the different layers of epithelial plasticity in cancer, encompassing the core layer of transcription factors, their interacting epigenetic modifiers and non-coding RNAs, and the manipulation of cancer immunogenicity in transitioning between epithelial and mesenchymal states. In examining these factors, we provide insights into promising therapeutic avenues and potential anti-cancer targets." @default.
- W4380365298 created "2023-06-13" @default.
- W4380365298 creator A5004957581 @default.
- W4380365298 creator A5021842747 @default.
- W4380365298 creator A5022898788 @default.
- W4380365298 creator A5027726048 @default.
- W4380365298 creator A5029344208 @default.
- W4380365298 creator A5041941022 @default.
- W4380365298 creator A5052122800 @default.
- W4380365298 date "2023-06-11" @default.
- W4380365298 modified "2023-10-09" @default.
- W4380365298 title "Unpacking the Complexity of Epithelial Plasticity: From Master Regulator Transcription Factors to Non-Coding RNAs" @default.
- W4380365298 cites W1512694675 @default.
- W4380365298 cites W1519912424 @default.
- W4380365298 cites W1529132978 @default.
- W4380365298 cites W1581655059 @default.
- W4380365298 cites W1689351220 @default.
- W4380365298 cites W1775309324 @default.
- W4380365298 cites W1788753937 @default.
- W4380365298 cites W1804495077 @default.
- W4380365298 cites W1805581579 @default.
- W4380365298 cites W1856759927 @default.
- W4380365298 cites W1882072066 @default.
- W4380365298 cites W1964681893 @default.
- W4380365298 cites W1964847767 @default.
- W4380365298 cites W1965279152 @default.
- W4380365298 cites W1965568527 @default.
- W4380365298 cites W1967135832 @default.
- W4380365298 cites W1967673384 @default.
- W4380365298 cites W1969576898 @default.
- W4380365298 cites W1976324983 @default.
- W4380365298 cites W1978802427 @default.
- W4380365298 cites W1979521500 @default.
- W4380365298 cites W1981106225 @default.
- W4380365298 cites W1984430627 @default.
- W4380365298 cites W1986834354 @default.
- W4380365298 cites W1993425229 @default.
- W4380365298 cites W1996863944 @default.
- W4380365298 cites W2002784328 @default.
- W4380365298 cites W2005852730 @default.
- W4380365298 cites W2007750524 @default.
- W4380365298 cites W2014666371 @default.
- W4380365298 cites W2014691022 @default.
- W4380365298 cites W2018536688 @default.
- W4380365298 cites W2018819150 @default.
- W4380365298 cites W2019882992 @default.
- W4380365298 cites W2030349812 @default.
- W4380365298 cites W2030753263 @default.
- W4380365298 cites W2033550998 @default.
- W4380365298 cites W2035396934 @default.
- W4380365298 cites W2046229170 @default.
- W4380365298 cites W2046768931 @default.
- W4380365298 cites W2052658057 @default.
- W4380365298 cites W2052821169 @default.
- W4380365298 cites W2053346430 @default.
- W4380365298 cites W2054621094 @default.
- W4380365298 cites W2056679107 @default.
- W4380365298 cites W2057329290 @default.
- W4380365298 cites W2059411043 @default.
- W4380365298 cites W2061301308 @default.
- W4380365298 cites W2063464619 @default.
- W4380365298 cites W2066800750 @default.
- W4380365298 cites W2066808368 @default.
- W4380365298 cites W2068517905 @default.
- W4380365298 cites W2069266255 @default.
- W4380365298 cites W2069989642 @default.
- W4380365298 cites W2076203883 @default.
- W4380365298 cites W2076427374 @default.
- W4380365298 cites W2079807560 @default.
- W4380365298 cites W2080457126 @default.
- W4380365298 cites W2080977583 @default.
- W4380365298 cites W2086179251 @default.
- W4380365298 cites W2089001345 @default.
- W4380365298 cites W2090913994 @default.
- W4380365298 cites W2093464881 @default.
- W4380365298 cites W2093965955 @default.
- W4380365298 cites W2094279499 @default.
- W4380365298 cites W2098891057 @default.
- W4380365298 cites W2099050199 @default.
- W4380365298 cites W2100669034 @default.
- W4380365298 cites W2102876017 @default.
- W4380365298 cites W2103591458 @default.
- W4380365298 cites W2107151134 @default.
- W4380365298 cites W2108490725 @default.
- W4380365298 cites W2108786888 @default.
- W4380365298 cites W2110937119 @default.
- W4380365298 cites W2112666597 @default.
- W4380365298 cites W2114154136 @default.
- W4380365298 cites W2121189598 @default.
- W4380365298 cites W2122159093 @default.
- W4380365298 cites W2122713601 @default.
- W4380365298 cites W2124156632 @default.
- W4380365298 cites W2126676188 @default.
- W4380365298 cites W2127754394 @default.
- W4380365298 cites W2128627710 @default.
- W4380365298 cites W2129124145 @default.
- W4380365298 cites W2130463979 @default.
- W4380365298 cites W2135093967 @default.