Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380366931> ?p ?o ?g. }
- W4380366931 endingPage "1115" @default.
- W4380366931 startingPage "1106" @default.
- W4380366931 abstract "The current understanding of the genetic determinants of thoracic aortic aneurysms and dissections (TAAD) has largely been informed through studies of rare, Mendelian forms of disease. Here, we conducted a genome-wide association study (GWAS) of TAAD, testing ~25 million DNA sequence variants in 8,626 participants with and 453,043 participants without TAAD in the Million Veteran Program, with replication in an independent sample of 4,459 individuals with and 512,463 without TAAD from six cohorts. We identified 21 TAAD risk loci, 17 of which have not been previously reported. We leverage multiple downstream analytic methods to identify causal TAAD risk genes and cell types and provide human genetic evidence that TAAD is a non-atherosclerotic aortic disorder distinct from other forms of vascular disease. Our results demonstrate that the genetic architecture of TAAD mirrors that of other complex traits and that it is not solely inherited through protein-altering variants of large effect size." @default.
- W4380366931 created "2023-06-13" @default.
- W4380366931 creator A5004020956 @default.
- W4380366931 creator A5006649339 @default.
- W4380366931 creator A5010313476 @default.
- W4380366931 creator A5012389323 @default.
- W4380366931 creator A5013403466 @default.
- W4380366931 creator A5014525847 @default.
- W4380366931 creator A5019081201 @default.
- W4380366931 creator A5022150335 @default.
- W4380366931 creator A5022675390 @default.
- W4380366931 creator A5024138963 @default.
- W4380366931 creator A5040805506 @default.
- W4380366931 creator A5041835190 @default.
- W4380366931 creator A5043295370 @default.
- W4380366931 creator A5043987277 @default.
- W4380366931 creator A5044024960 @default.
- W4380366931 creator A5047405500 @default.
- W4380366931 creator A5047884631 @default.
- W4380366931 creator A5051121133 @default.
- W4380366931 creator A5057965099 @default.
- W4380366931 creator A5061586298 @default.
- W4380366931 creator A5062426818 @default.
- W4380366931 creator A5064955311 @default.
- W4380366931 creator A5067149045 @default.
- W4380366931 creator A5069822855 @default.
- W4380366931 creator A5070396033 @default.
- W4380366931 creator A5072318460 @default.
- W4380366931 creator A5075343690 @default.
- W4380366931 creator A5079135645 @default.
- W4380366931 creator A5080053699 @default.
- W4380366931 creator A5080251530 @default.
- W4380366931 creator A5081769614 @default.
- W4380366931 creator A5082013900 @default.
- W4380366931 creator A5082890040 @default.
- W4380366931 creator A5083174383 @default.
- W4380366931 creator A5085527131 @default.
- W4380366931 creator A5087932701 @default.
- W4380366931 date "2023-06-12" @default.
- W4380366931 modified "2023-10-17" @default.
- W4380366931 title "Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program" @default.
- W4380366931 cites W1968304646 @default.
- W4380366931 cites W1969208427 @default.
- W4380366931 cites W1969325849 @default.
- W4380366931 cites W1971898007 @default.
- W4380366931 cites W2004755098 @default.
- W4380366931 cites W2030705868 @default.
- W4380366931 cites W2033151532 @default.
- W4380366931 cites W2049806614 @default.
- W4380366931 cites W2051978340 @default.
- W4380366931 cites W2066748421 @default.
- W4380366931 cites W2077559627 @default.
- W4380366931 cites W2087758397 @default.
- W4380366931 cites W2095326161 @default.
- W4380366931 cites W2100139763 @default.
- W4380366931 cites W2104549677 @default.
- W4380366931 cites W2113105800 @default.
- W4380366931 cites W2113699335 @default.
- W4380366931 cites W2119279196 @default.
- W4380366931 cites W2132519011 @default.
- W4380366931 cites W2132831536 @default.
- W4380366931 cites W2133520037 @default.
- W4380366931 cites W2136273720 @default.
- W4380366931 cites W2137200150 @default.
- W4380366931 cites W2139852278 @default.
- W4380366931 cites W2153118028 @default.
- W4380366931 cites W2163969089 @default.
- W4380366931 cites W2170542922 @default.
- W4380366931 cites W2171212089 @default.
- W4380366931 cites W2264585211 @default.
- W4380366931 cites W2345621280 @default.
- W4380366931 cites W2476542314 @default.
- W4380366931 cites W2517346827 @default.
- W4380366931 cites W2521967673 @default.
- W4380366931 cites W2528302205 @default.
- W4380366931 cites W2584469054 @default.
- W4380366931 cites W2761275051 @default.
- W4380366931 cites W2771024553 @default.
- W4380366931 cites W2803072880 @default.
- W4380366931 cites W2805983714 @default.
- W4380366931 cites W2886752110 @default.
- W4380366931 cites W2887657552 @default.
- W4380366931 cites W2889800760 @default.
- W4380366931 cites W2949177718 @default.
- W4380366931 cites W2950709928 @default.
- W4380366931 cites W2952843612 @default.
- W4380366931 cites W2953357410 @default.
- W4380366931 cites W2972751683 @default.
- W4380366931 cites W2998822473 @default.
- W4380366931 cites W3029661147 @default.
- W4380366931 cites W3048245060 @default.
- W4380366931 cites W3048963803 @default.
- W4380366931 cites W3082438439 @default.
- W4380366931 cites W3088087046 @default.
- W4380366931 cites W3090295751 @default.
- W4380366931 cites W3094777985 @default.
- W4380366931 cites W3099862724 @default.
- W4380366931 cites W3154400205 @default.