FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380372912> ?p ?o ?g. }

• W4380372912 endingPage "122324" @default.
• W4380372912 startingPage "122324" @default.
• W4380372912 abstract "Cell membranes constitute the first barrier for the drugs on their way to the cell. Therefore, their penetration determines the effectivity of the treatment and is defined by the drug-lipid interactions. A systematic, comprehensive study to assess the impact of different aspects influencing the effective penetration of model lipid membranes by the drugs including lipophilicity, charge, ability to form dimers as well as stearic hindrance was performed. Four anthracyclines differing in the structure and with lipophilicity increasing in the following order: doxorubicin (DOx) < pirarubicin (THP) < daunorubicin (DNR) < idarubicin (IDA) were chosen to assess their impact on 1,2-dimyristoyl-sn-glycero-3-phospho-L-serine (DMPS) monolayers mimicking cancer cell membranes. The investigation performed at the air–water interface involved the application of multiple surface-sensitive techniques to assess the drug interactions with both polar heads of the phospholipid and the penetration of the acyl chain region. The obtained results allowed us to state that although electrostatic interactions and lipophilicity of the drug are one of the key factors, the ability to form dimers as well as stearic hinderance may strongly prevent from the effective penetration of the phospholipid monolayers even for drugs with higher lipophilicity and therefore have to be also taken into account in the development of new therapeutic agents." @default.
• W4380372912 created "2023-06-13" @default.
• W4380372912 creator A5049043201 @default.
• W4380372912 creator A5077912444 @default.
• W4380372912 creator A5083215539 @default.
• W4380372912 date "2023-09-01" @default.
• W4380372912 modified "2023-09-26" @default.
• W4380372912 title "Is lipophilicity the main factor determining the effective drug penetration through lipid membranes? Combined GIXD and PM-IRRAS studies on the example of anthracyclines" @default.
• W4380372912 cites W1971866561 @default.
• W4380372912 cites W1982689015 @default.
• W4380372912 cites W1985315523 @default.
• W4380372912 cites W1985400133 @default.
• W4380372912 cites W1991683400 @default.
• W4380372912 cites W1997360560 @default.
• W4380372912 cites W1997948514 @default.
• W4380372912 cites W2002016900 @default.
• W4380372912 cites W2002372426 @default.
• W4380372912 cites W2008388668 @default.
• W4380372912 cites W2022390473 @default.
• W4380372912 cites W2023275725 @default.
• W4380372912 cites W2029267597 @default.
• W4380372912 cites W2050363384 @default.
• W4380372912 cites W2052770850 @default.
• W4380372912 cites W2055408808 @default.
• W4380372912 cites W2057610656 @default.
• W4380372912 cites W2059106379 @default.
• W4380372912 cites W2062074008 @default.
• W4380372912 cites W2062298836 @default.
• W4380372912 cites W2063385021 @default.
• W4380372912 cites W2069403916 @default.
• W4380372912 cites W2080617719 @default.
• W4380372912 cites W2081932070 @default.
• W4380372912 cites W2083154121 @default.
• W4380372912 cites W2090736734 @default.
• W4380372912 cites W2099612035 @default.
• W4380372912 cites W2102729772 @default.
• W4380372912 cites W2104013724 @default.
• W4380372912 cites W2128086136 @default.
• W4380372912 cites W2129944090 @default.
• W4380372912 cites W2146974131 @default.
• W4380372912 cites W2151640043 @default.
• W4380372912 cites W2187199771 @default.
• W4380372912 cites W2335086159 @default.
• W4380372912 cites W2611626585 @default.
• W4380372912 cites W2792090860 @default.
• W4380372912 cites W2793681682 @default.
• W4380372912 cites W2799755107 @default.
• W4380372912 cites W2800126433 @default.
• W4380372912 cites W2804324369 @default.
• W4380372912 cites W2924707811 @default.
• W4380372912 cites W2949001752 @default.
• W4380372912 cites W2982501452 @default.
• W4380372912 cites W2998853989 @default.
• W4380372912 cites W3020647490 @default.
• W4380372912 cites W3035258905 @default.
• W4380372912 cites W3045190875 @default.
• W4380372912 cites W3094000074 @default.
• W4380372912 cites W3158633868 @default.
• W4380372912 cites W4200104379 @default.
• W4380372912 cites W4210689006 @default.
• W4380372912 cites W4231005769 @default.
• W4380372912 cites W4246752300 @default.
• W4380372912 cites W4297965111 @default.
• W4380372912 doi "https://doi.org/10.1016/j.molliq.2023.122324" @default.
• W4380372912 hasPublicationYear "2023" @default.
• W4380372912 type Work @default.
• W4380372912 citedByCount "0" @default.
• W4380372912 crossrefType "journal-article" @default.
• W4380372912 hasAuthorship W4380372912A5049043201 @default.
• W4380372912 hasAuthorship W4380372912A5077912444 @default.
• W4380372912 hasAuthorship W4380372912A5083215539 @default.
• W4380372912 hasBestOaLocation W43803729121 @default.
• W4380372912 hasConcept C12554922 @default.
• W4380372912 hasConcept C127413603 @default.
• W4380372912 hasConcept C185592680 @default.
• W4380372912 hasConcept C201399114 @default.
• W4380372912 hasConcept C2778918659 @default.
• W4380372912 hasConcept C2780035454 @default.
• W4380372912 hasConcept C39944091 @default.
• W4380372912 hasConcept C41625074 @default.
• W4380372912 hasConcept C42475967 @default.
• W4380372912 hasConcept C55493867 @default.
• W4380372912 hasConcept C71240020 @default.
• W4380372912 hasConcept C71924100 @default.
• W4380372912 hasConcept C80107235 @default.
• W4380372912 hasConcept C86803240 @default.
• W4380372912 hasConcept C98274493 @default.
• W4380372912 hasConceptScore W4380372912C12554922 @default.
• W4380372912 hasConceptScore W4380372912C127413603 @default.
• W4380372912 hasConceptScore W4380372912C185592680 @default.
• W4380372912 hasConceptScore W4380372912C201399114 @default.
• W4380372912 hasConceptScore W4380372912C2778918659 @default.
• W4380372912 hasConceptScore W4380372912C2780035454 @default.
• W4380372912 hasConceptScore W4380372912C39944091 @default.
• W4380372912 hasConceptScore W4380372912C41625074 @default.
• W4380372912 hasConceptScore W4380372912C42475967 @default.
• W4380372912 hasConceptScore W4380372912C55493867 @default.
• W4380372912 hasConceptScore W4380372912C71240020 @default.

• next