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• W4380422969 abstract "Objective: To investigate the effects of one-time exhaustive exercise on coagulation state in rats and its mechanism. Methods: Forty-eight SD rats were randomly divided into control group and exhaustive exercise group, 24 rats in each group. Rats in exhaustive exercise group were trained with treadmill training for 25～50 min at a time on non-slope treadmill and the initial speed of 5 m/min was uniformly accelerated to 25 m/min until the rats exhausted. Thrombelastography (TEG) was used to monitor the coagulation function of rats after training. The ligation model of inferior vena cava (IVC) was established to evaluate thrombosis. The phosphatidylserine (PS) exposure and Ca2+ concentration were detected by flow cytometry. The production of FXa and thrombin was detected by microplate reader. The clotting time was measured by using coagulometer. Results: Compared with the control group, the blood of rats in the exhaustive exercise group exhibited hypercoagulable state. The probability of thrombus formation, weight, length and ratio in the exhaustive exercise group were significantly higher than those in the control group (P＜0.01). The levels of PS exposure and intracellular Ca2+ concentration of red blood cells (RBCs) and platelets in the exhaustive exercise group were increased significantly (P＜0.01). The blood clotting time of RBCs and platelets was shortened (P＜0.01), and the production of FXa and thrombin was increased significantly (P＜0.01) in the exhausted exercise group, and both were inhibited by lactadherin (Lact, P＜0.01). Conclusion: The blood of exhaustive exercise rats is in a hypercoagulable state and the risk of thrombosis is increased. The increased PS exposure of RBCs and platelets caused by exhaustive exercise may be an important mechanism of thrombosis.目的: 探究一次性力竭运动对大鼠凝血状态的影响及其机制。方法: 48只SD大鼠随机分为对照组和力竭运动组,每组24只。力竭运动组大鼠采用无坡度跑台进行一次性跑台训练25～50 min,以5 m/min的初始速度匀加速运动至25 m/min,直至大鼠力竭。训练结束后利用血栓弹力图监测大鼠凝血功能;建立下腔静脉结扎模型评估血栓形成倾向;流式细胞术检测磷脂酰丝氨酸(PS)外翻和Ca2+浓度;酶标仪检测FXa和凝血酶生成;血凝仪检测凝血时间。结果: 与对照组比较,力竭运动组大鼠血液呈高凝状态,血栓形成几率、重量、长度及其比值均明显升高(P＜0.01),大鼠红细胞和血小板PS外翻水平均明显升高(P＜0.01),且细胞内Ca2+浓度明显升高(P＜ 0.01),大鼠红细胞和血小板凝血时间明显缩短(P＜0.01),FXa和凝血酶生成明显升高(P＜0.01),且均可被乳粘素(Lact)抑制(P＜0.01)。结论: 力竭运动大鼠血液呈高凝状态,血栓形成风险增高,力竭运动导致的Ca2+依赖的红细胞及血小板PS外翻增多可能是其血栓形成的重要机制。." @default.
• W4380422969 created "2023-06-14" @default.
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• W4380422969 date "2022-11-01" @default.
• W4380422969 modified "2023-09-23" @default.
• W4380422969 title "[Effects of exhaustive exercise on coagulation state in rats]." @default.
• W4380422969 doi "https://doi.org/10.12047/j.cjap.6372.2022.130" @default.
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