Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380423216> ?p ?o ?g. }
- W4380423216 abstract "Abstract Cancer cachexia is a wasting syndrome characterised by the loss of fat and/or muscle mass in advanced cancer patients. It has been well‐established that cancer cells themselves can induce cachexia via the release of several pro‐cachectic and pro‐inflammatory factors. However, it is unclear how this process is regulated and the key cachexins that are involved. In this study, we validated C26 and EL4 as cachexic and non‐cachexic cell models, respectively. Treatment of adipocytes and myotubes with C26 conditioned medium induced lipolysis and atrophy, respectively. We profiled soluble secreted proteins (secretome) as well as small extracellular vesicles (sEVs) released from cachexia‐inducing (C26) and non‐inducing (EL4) cancer cells by label‐free quantitative proteomics. A total of 1268 and 1022 proteins were identified in the secretome of C26 and EL4, respectively. Furthermore, proteomic analysis of sEVs derived from C26 and EL4 cancer cells revealed a distinct difference in the protein cargo. Functional enrichment analysis using FunRich highlighted the enrichment of proteins that are implicated in biological processes such as muscle atrophy, lipolysis, and inflammation in both the secretome and sEVs derived from C26 cancer cells. Overall, our characterisation of the proteomic profiles of the secretory factors and sEVs from cachexia‐inducing and non‐inducing cancer cells provides insights into tumour factors that promote weight loss by mediating protein and lipid loss in various organs and tissues. Further investigation of these proteins may assist in highlighting potential therapeutic targets and biomarkers of cancer cachexia." @default.
- W4380423216 created "2023-06-14" @default.
- W4380423216 creator A5000637813 @default.
- W4380423216 creator A5008737932 @default.
- W4380423216 creator A5010935820 @default.
- W4380423216 creator A5042879137 @default.
- W4380423216 creator A5057079391 @default.
- W4380423216 creator A5057880695 @default.
- W4380423216 creator A5058055203 @default.
- W4380423216 creator A5065122221 @default.
- W4380423216 creator A5066701356 @default.
- W4380423216 creator A5073955680 @default.
- W4380423216 creator A5092150550 @default.
- W4380423216 date "2023-06-13" @default.
- W4380423216 modified "2023-09-26" @default.
- W4380423216 title "Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non‐inducing cancer cells" @default.
- W4380423216 cites W1797058518 @default.
- W4380423216 cites W1971992633 @default.
- W4380423216 cites W1972470375 @default.
- W4380423216 cites W1973767788 @default.
- W4380423216 cites W1977826342 @default.
- W4380423216 cites W1982992710 @default.
- W4380423216 cites W1985534077 @default.
- W4380423216 cites W2007845148 @default.
- W4380423216 cites W2022514199 @default.
- W4380423216 cites W2039509275 @default.
- W4380423216 cites W2046822738 @default.
- W4380423216 cites W2065261951 @default.
- W4380423216 cites W2065635384 @default.
- W4380423216 cites W2076277955 @default.
- W4380423216 cites W2079300172 @default.
- W4380423216 cites W2079861851 @default.
- W4380423216 cites W2096488601 @default.
- W4380423216 cites W2111538369 @default.
- W4380423216 cites W2116819815 @default.
- W4380423216 cites W2121689536 @default.
- W4380423216 cites W2126536849 @default.
- W4380423216 cites W2136537310 @default.
- W4380423216 cites W2140722942 @default.
- W4380423216 cites W2145280166 @default.
- W4380423216 cites W2157072221 @default.
- W4380423216 cites W2162987503 @default.
- W4380423216 cites W2165209275 @default.
- W4380423216 cites W2279428213 @default.
- W4380423216 cites W2463195069 @default.
- W4380423216 cites W2528646259 @default.
- W4380423216 cites W2544360569 @default.
- W4380423216 cites W2594758945 @default.
- W4380423216 cites W2739309812 @default.
- W4380423216 cites W2754168513 @default.
- W4380423216 cites W2755828237 @default.
- W4380423216 cites W2784374589 @default.
- W4380423216 cites W2807282637 @default.
- W4380423216 cites W2809247618 @default.
- W4380423216 cites W2890379689 @default.
- W4380423216 cites W2899278816 @default.
- W4380423216 cites W2901644252 @default.
- W4380423216 cites W2903362839 @default.
- W4380423216 cites W2936880972 @default.
- W4380423216 cites W2987952581 @default.
- W4380423216 cites W3005484759 @default.
- W4380423216 cites W3009962865 @default.
- W4380423216 cites W3014445498 @default.
- W4380423216 cites W3024392795 @default.
- W4380423216 cites W3028453792 @default.
- W4380423216 cites W3081415700 @default.
- W4380423216 cites W3110648523 @default.
- W4380423216 cites W3126363544 @default.
- W4380423216 cites W3143855543 @default.
- W4380423216 cites W3177083875 @default.
- W4380423216 cites W3210163759 @default.
- W4380423216 cites W4200206534 @default.
- W4380423216 cites W4206211052 @default.
- W4380423216 cites W4308043437 @default.
- W4380423216 cites W4311040489 @default.
- W4380423216 doi "https://doi.org/10.1002/pmic.202100314" @default.
- W4380423216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37309723" @default.
- W4380423216 hasPublicationYear "2023" @default.
- W4380423216 type Work @default.
- W4380423216 citedByCount "0" @default.
- W4380423216 crossrefType "journal-article" @default.
- W4380423216 hasAuthorship W4380423216A5000637813 @default.
- W4380423216 hasAuthorship W4380423216A5008737932 @default.
- W4380423216 hasAuthorship W4380423216A5010935820 @default.
- W4380423216 hasAuthorship W4380423216A5042879137 @default.
- W4380423216 hasAuthorship W4380423216A5057079391 @default.
- W4380423216 hasAuthorship W4380423216A5057880695 @default.
- W4380423216 hasAuthorship W4380423216A5058055203 @default.
- W4380423216 hasAuthorship W4380423216A5065122221 @default.
- W4380423216 hasAuthorship W4380423216A5066701356 @default.
- W4380423216 hasAuthorship W4380423216A5073955680 @default.
- W4380423216 hasAuthorship W4380423216A5092150550 @default.
- W4380423216 hasBestOaLocation W43804232161 @default.
- W4380423216 hasConcept C104317684 @default.
- W4380423216 hasConcept C104397665 @default.
- W4380423216 hasConcept C121608353 @default.
- W4380423216 hasConcept C140985366 @default.
- W4380423216 hasConcept C171089720 @default.
- W4380423216 hasConcept C2777704314 @default.
- W4380423216 hasConcept C28406088 @default.