FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380447777> ?p ?o ?g. }

• W4380447777 abstract "Abstract Background and Aims Modern immunosuppressive protocols are associated with less loss of bone mass immediately after kidney transplantation, as compared with previous eras. Even so, bone microarchitecture may still be disturbed due to long-standing uremia, leading to bone fragility and fracture susceptibility. Trabecular bone score (TBS) is a new tool to assess trabecular bone microarchitecture based on standard dual energy X-ray absorptiometry (DXA) of lumbar spine images. TBS reflects bone quality rather than quantity. Studies on the effect of common anti-fracture strategies on TBS in kidney transplant recipients (KTR) are scarce. Our aim was to investigate different treatments on bone microarchitecture by TBS in KTR. Method We analyzed TBS changes and potential treatment effects in 179 de novo KTR, 118 of whom had participated in a randomized controlled trial[1] evaluating the effect of ibandronate (active/placebo) on top of calcium and vitamin D in the first year after kidney transplantation. Trial participants were compared to 61 patients transplanted in the same time-period, meeting the same study inclusion criteria, but receiving no specific bone-directed treatment. Correlations between changes in TBS and lumbar spine BMD were investigated. We used ANOVA and ANCOVA with adjustment for baseline TBS values to evaluate the potential effects of calcium and vitamin D with/without concomitant ibandronate on TBS 12 months after transplantation, as compared to no treatment. Results Mean TBS increased in all groups from baseline to 12 months after transplantation (2.1% for ibandronate/calcium/vitamin D, 2.7% for calcium/vitamin D, and 3.4% for no treatment). Adjusting for baseline TBS, there were no significant differences in TBS at 12 months, neither with overall comparison (p = 0.377) nor when comparing the groups pairwise. The correlation between TBS and BMD was weak (r = 0.170, p = 0.02) at baseline, and change in TBS was not significantly correlated with change in lumbar spine BMD in any of the groups. Conclusion In a group of de novo KTR with reasonably well-preserved bone mass, it does not appear that one year of treatment with ibandronate or calcium and vitamin D significantly affects bone quality as measured by TBS. We found surprisingly weak correlation between changes in TBS and BMD over the study period, indicating that these measurements reflect different aspects of bone integrity and metabolism. This study strengthens the view that focus should be on identifying KTR at high risk of fracture at time of transplantation, as these patients could benefit from anti-resorptive therapy." @default.
• W4380447777 created "2023-06-14" @default.
• W4380447777 creator A5009100284 @default.
• W4380447777 creator A5010451635 @default.
• W4380447777 creator A5012578202 @default.
• W4380447777 creator A5013365304 @default.
• W4380447777 creator A5018806995 @default.
• W4380447777 creator A5038378874 @default.
• W4380447777 creator A5043291551 @default.
• W4380447777 creator A5045197704 @default.
• W4380447777 date "2023-06-01" @default.
• W4380447777 modified "2023-09-26" @default.
• W4380447777 title "#3641 DOES IBANDRONATE OR CALCIUM AND VITAMIN D MAINTAIN OR IMPROVE BONE MICROARCHITECTURE IN THE FIRST YEAR AFTER KIDNEY TRANSPLANTATION?" @default.
• W4380447777 doi "https://doi.org/10.1093/ndt/gfad063c_3641" @default.
• W4380447777 hasPublicationYear "2023" @default.
• W4380447777 type Work @default.
• W4380447777 citedByCount "0" @default.
• W4380447777 crossrefType "journal-article" @default.
• W4380447777 hasAuthorship W4380447777A5009100284 @default.
• W4380447777 hasAuthorship W4380447777A5010451635 @default.
• W4380447777 hasAuthorship W4380447777A5012578202 @default.
• W4380447777 hasAuthorship W4380447777A5013365304 @default.
• W4380447777 hasAuthorship W4380447777A5018806995 @default.
• W4380447777 hasAuthorship W4380447777A5038378874 @default.
• W4380447777 hasAuthorship W4380447777A5043291551 @default.
• W4380447777 hasAuthorship W4380447777A5045197704 @default.
• W4380447777 hasBestOaLocation W43804477771 @default.
• W4380447777 hasConcept C124490489 @default.
• W4380447777 hasConcept C126322002 @default.
• W4380447777 hasConcept C126894567 @default.
• W4380447777 hasConcept C141071460 @default.
• W4380447777 hasConcept C2776343214 @default.
• W4380447777 hasConcept C2776541429 @default.
• W4380447777 hasConcept C2776886416 @default.
• W4380447777 hasConcept C2777425516 @default.
• W4380447777 hasConcept C2780303639 @default.
• W4380447777 hasConcept C2911091166 @default.
• W4380447777 hasConcept C519063684 @default.
• W4380447777 hasConcept C71924100 @default.
• W4380447777 hasConceptScore W4380447777C124490489 @default.
• W4380447777 hasConceptScore W4380447777C126322002 @default.
• W4380447777 hasConceptScore W4380447777C126894567 @default.
• W4380447777 hasConceptScore W4380447777C141071460 @default.
• W4380447777 hasConceptScore W4380447777C2776343214 @default.
• W4380447777 hasConceptScore W4380447777C2776541429 @default.
• W4380447777 hasConceptScore W4380447777C2776886416 @default.
• W4380447777 hasConceptScore W4380447777C2777425516 @default.
• W4380447777 hasConceptScore W4380447777C2780303639 @default.
• W4380447777 hasConceptScore W4380447777C2911091166 @default.
• W4380447777 hasConceptScore W4380447777C519063684 @default.
• W4380447777 hasConceptScore W4380447777C71924100 @default.
• W4380447777 hasIssue "Supplement_1" @default.
• W4380447777 hasLocation W43804477771 @default.
• W4380447777 hasOpenAccess W4380447777 @default.
• W4380447777 hasPrimaryLocation W43804477771 @default.
• W4380447777 hasRelatedWork W2396393640 @default.
• W4380447777 hasRelatedWork W2403408057 @default.
• W4380447777 hasRelatedWork W2419369960 @default.
• W4380447777 hasRelatedWork W2570861097 @default.
• W4380447777 hasRelatedWork W2964197801 @default.
• W4380447777 hasRelatedWork W3039769869 @default.
• W4380447777 hasRelatedWork W3178251481 @default.
• W4380447777 hasRelatedWork W4318460174 @default.
• W4380447777 hasRelatedWork W4320914166 @default.
• W4380447777 hasRelatedWork W2129922394 @default.
• W4380447777 hasVolume "38" @default.
• W4380447777 isParatext "false" @default.
• W4380447777 isRetracted "false" @default.
• W4380447777 workType "article" @default.