FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380448001> ?p ?o ?g. }

• W4380448001 abstract "Abstract Background and Aims Literature regarding pregnancy management and outcomes in women with glomerulopathies is still sparse. Specific guidelines for each glomerulopathy are still lacking which impairs a more homogeneous approach. The authors describe the multidisciplinary approach and the outcomes of pregnant women with primary and genetic glomerulopathies. Method Retrospective observational study in which the authors reviewed maternal, obstetric and perinatal outcomes in pregnant women with primary and genetic glomerulopathies surveilled at our nephro-obstetric clinic from 2011 to 2021. Results We evaluated 23 gestations in 20 patients (two pregnancies still ongoing). Mean age was 32.4±5.4 years (18-41), 17 women were caucasian, 3 black African, 10/23 nulliparous and 5/20 had chronic hypertension. Mean baseline SCr was 0.8±0.3mg/dl (0.5-1.8) and proteinuria was 1360±2199.6 mg/day (150-8615), with 13/6/2 patients being on CKD stage 1/2/3, before pregnancy, respectively (unknown in 2 patients). The most frequent CKD etiologies were IgA nephropathy (6/20), Focal Segmental Glomerulosclerosis (FSGS; 3/20) and Membranous nephropathy (2/20). Exposure to teratogenic therapy during the 1st trimester occurred in 5/23 gestations with a mean exposure of 7.0±3.6 weeks. De novo proteinuria and worsening proteinuria occurred in 3/23 and 16/23 patients, respectively, with full blown nephrotic syndrome in 4/23 patients. Renal function deteriorated in one patient (CKD G3). Kidney biopsy was performed in 1/20 and 3/20 patients during and post pregnancy, revealing IgA Nephropathy (2/20, 1 with superimposed FSGS), C3 glomerulonephritis (1/20) and FSGS (1/20). Genetic diagnosis was done during/post pregnancy in 3/1 patients. Aspirin and LMWH were started in 17/23 and 4/23 gestations, respectively. Immunosuppression consisted of cyclosporin or tacrolimus with or without low dose prednisolone in 6/23 patients with partial and complete remission in all patients. De novo and worsening hypertension occurred in 2/23 and 3/23 gestations, during the 3rd trimester. Preeclampsia developed in 1 patient at 32 weeks. Fetus malformation (trisomy 21) and severe nephrotic syndrome led to pregnancy termination during the 1st trimester in two pregnancies. Cesarean delivery was performed in 5 gestations mainly due to pelvic position. Mean gestation time was 38.9±2 weeks. There was one preterm delivery due to preeclampsia. Mean birth weight was 3076.6±630.7 mg (1500-3850), with 3 newborns having low birth weight (&lt;2500g). Apgar scores at 1/5/10 minutes were 9/10/10, respectively. Neonatal intensive care was needed in 1 newborn. Conclusion In our series, glomerulopathies with proteinuria or nephrotic syndrome were not associated with poor renal and perinatal outcome, with only one patient developing PE and renal function deterioration, probably associated to with CKD stage 3. In patients with nephrotic syndrome, immunosuppression with calcineurin inhibitor and low dose prednisone was associated with complete or partial remission in all patients." @default.
• W4380448001 created "2023-06-14" @default.
• W4380448001 creator A5046145988 @default.
• W4380448001 creator A5052676074 @default.
• W4380448001 creator A5060211001 @default.
• W4380448001 creator A5075858091 @default.
• W4380448001 creator A5077847108 @default.
• W4380448001 creator A5091376918 @default.
• W4380448001 date "2023-06-01" @default.
• W4380448001 modified "2023-09-23" @default.
• W4380448001 title "#3512 GLOMERULOPATHIES DURING PREGNANCY: A TEN-YEAR SINGLE CENTER EXPERIENCE" @default.
• W4380448001 doi "https://doi.org/10.1093/ndt/gfad063c_3512" @default.
• W4380448001 hasPublicationYear "2023" @default.
• W4380448001 type Work @default.
• W4380448001 citedByCount "0" @default.
• W4380448001 crossrefType "journal-article" @default.
• W4380448001 hasAuthorship W4380448001A5046145988 @default.
• W4380448001 hasAuthorship W4380448001A5052676074 @default.
• W4380448001 hasAuthorship W4380448001A5060211001 @default.
• W4380448001 hasAuthorship W4380448001A5075858091 @default.
• W4380448001 hasAuthorship W4380448001A5077847108 @default.
• W4380448001 hasAuthorship W4380448001A5091376918 @default.
• W4380448001 hasBestOaLocation W43804480011 @default.
• W4380448001 hasConcept C126322002 @default.
• W4380448001 hasConcept C131872663 @default.
• W4380448001 hasConcept C134018914 @default.
• W4380448001 hasConcept C159641895 @default.
• W4380448001 hasConcept C2778415529 @default.
• W4380448001 hasConcept C2778653478 @default.
• W4380448001 hasConcept C2779234561 @default.
• W4380448001 hasConcept C2779561371 @default.
• W4380448001 hasConcept C2780091579 @default.
• W4380448001 hasConcept C2781184683 @default.
• W4380448001 hasConcept C46973012 @default.
• W4380448001 hasConcept C54355233 @default.
• W4380448001 hasConcept C555293320 @default.
• W4380448001 hasConcept C71924100 @default.
• W4380448001 hasConcept C86803240 @default.
• W4380448001 hasConceptScore W4380448001C126322002 @default.
• W4380448001 hasConceptScore W4380448001C131872663 @default.
• W4380448001 hasConceptScore W4380448001C134018914 @default.
• W4380448001 hasConceptScore W4380448001C159641895 @default.
• W4380448001 hasConceptScore W4380448001C2778415529 @default.
• W4380448001 hasConceptScore W4380448001C2778653478 @default.
• W4380448001 hasConceptScore W4380448001C2779234561 @default.
• W4380448001 hasConceptScore W4380448001C2779561371 @default.
• W4380448001 hasConceptScore W4380448001C2780091579 @default.
• W4380448001 hasConceptScore W4380448001C2781184683 @default.
• W4380448001 hasConceptScore W4380448001C46973012 @default.
• W4380448001 hasConceptScore W4380448001C54355233 @default.
• W4380448001 hasConceptScore W4380448001C555293320 @default.
• W4380448001 hasConceptScore W4380448001C71924100 @default.
• W4380448001 hasConceptScore W4380448001C86803240 @default.
• W4380448001 hasIssue "Supplement_1" @default.
• W4380448001 hasLocation W43804480011 @default.
• W4380448001 hasOpenAccess W4380448001 @default.
• W4380448001 hasPrimaryLocation W43804480011 @default.
• W4380448001 hasRelatedWork W1551612911 @default.
• W4380448001 hasRelatedWork W1750454588 @default.
• W4380448001 hasRelatedWork W2047774009 @default.
• W4380448001 hasRelatedWork W2126629494 @default.
• W4380448001 hasRelatedWork W2144235147 @default.
• W4380448001 hasRelatedWork W2294871778 @default.
• W4380448001 hasRelatedWork W2400952411 @default.
• W4380448001 hasRelatedWork W2553772299 @default.
• W4380448001 hasRelatedWork W3112564589 @default.
• W4380448001 hasRelatedWork W3179606790 @default.
• W4380448001 hasVolume "38" @default.
• W4380448001 isParatext "false" @default.
• W4380448001 isRetracted "false" @default.
• W4380448001 workType "article" @default.