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- W4380448052 abstract "Abstract Background and Aims Crescentic glomerulonephritis (CrGN) is defined clinically by Rapidly progressive renal failure due to crescent formation in ≥ 50% of glomeruli. Most of these patients have a relatively poor prognosis. Therefore, early diagnose and treatment of these patients may help to prevent renal complications. There is a scarce data on pediatric CrGN. We aim to study the etiopathogenesis and outcome of CrGN in children and adolescents. Method Retrospective observational study of pediatric patients of age ≤ 18years with biopsy-proven CrGN from January 2010 to December 2021. Clinical and laboratory data with validated renal biopsy report were obtained from the hospital information system. CrGN was defined as crescents in ≥50% glomeruli. Rapidly Progressive Glomerulonephritis (RPGN) is the clinical presentation of CrGN, which is classified based on immunofluorescence findings and serology. Risk factors predicting poor renal outcome were determined. Results Of 47 (13.8% of total biopsy proven CrGN) patients, 30 were male patients (M:F ratio 1.7:1) and median age of 14 (range 7–18) years. 32 (68%) patients had immune complex GN and 14 (30%) had pauci-immune crescentic GN and 1 (2%) had anti-GBM Disease. Among Immune complex GN, the following aetiologies were found: IgA nephropathy (n=13, 27.6%), lupus nephritis (n=7, 15%), postinfectious GN (n=5, 11%), Henoch Schoenlein purpura (n=1, (2%), membranoproliferative GN type II (n=2, 4%) and others (n=5, 5%). 4 out of 14 patients with pauci-immune GN showed antineutrophil cytoplasmic antibodies (ANCA). 9 (19%) patients were dialysis dependent at the time of discharge. Patients with complete or partial remission were 23 (46.8%) at the time of discharge. Risk factors predicting poor renal outcome were oliguria, hypertension, interstitial fibrosis and tubular atrophy (IFTA), and serum creatinine at presentation. Conclusion Immune complex GN is the most common etiology, that constitutes 68% of patients with crescentic GN. Majority of pauci-immune GN were ANCA negative (71%). Poor renal outcome is related to severity of initial presentation and extent of IFTA." @default.
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- W4380448052 date "2023-06-01" @default.
- W4380448052 modified "2023-09-24" @default.
- W4380448052 title "#5035 CRESCENTIC GLOMERULONEPHRITIS IN A PAEDIATRIC POPULATION: A SINGLE-CENTRE EXPERIENCE FROM SOUTH ASIA" @default.
- W4380448052 doi "https://doi.org/10.1093/ndt/gfad063d_5035" @default.
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