Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380449712> ?p ?o ?g. }
- W4380449712 endingPage "9653" @default.
- W4380449712 startingPage "9646" @default.
- W4380449712 abstract "Fluorescent rotors with aggregation-induced emission (AIE) and organelle-targeting properties have attracted great attention for sensing subcellular viscosity changes, which could help understand the relationships of abnormal fluctuations with many associated diseases. Despite the numerous efforts spent, it remains rare and urgent to explore the dual-organelle targeting probes and their structural relationships with viscosity-responsive and AIE properties. Therefore, in this work, we reported four meso-five-membered heterocycle-substituted BODIPY-based fluorescent probes, explored their viscosity-responsive and AIE properties, and further investigated their subcellular localization and viscosity-sensing applications in living cells. Interestingly, the meso-thiazole probe 1 showed both good viscosity-responsive and AIE (in pure water) properties and could successfully target both mitochondria and lysosomes, further imaging cellular viscosity changes by treating lipopolysaccharide and nystatin, attributing to the free rotation and potential dual-organelle targeting ability of the meso-thiazole group. The meso-benzothiophene probe 3 with a saturated sulfur only showed good viscosity-responsive properties in living cells with the aggregation-caused quenching effect and no subcellular localization. The meso-imidazole probe 2 showed the AIE phenomenon without an obvious viscosity-responsive property with a C═N bond, while the meso-benzopyrrole probe 4 displayed fluorescence quenching in polar solvents. Therefore, for the first time, we investigated the structure–property relationships of four meso-five-membered heterocycle-substituted BODIPY-based fluorescent rotors with viscosity-responsive and AIE properties, and among these, 1 with a C═N bond and a saturated sulfur on the meso-thiazole, potentially contributing to their corresponding AIE and viscosity-responsive properties, served as a sensitive AIE fluorescent rotor for imaging dual-organelle viscosity in both mitochondria and lysosomes." @default.
- W4380449712 created "2023-06-14" @default.
- W4380449712 creator A5006894242 @default.
- W4380449712 creator A5022400812 @default.
- W4380449712 creator A5030507448 @default.
- W4380449712 creator A5031472196 @default.
- W4380449712 creator A5032132815 @default.
- W4380449712 creator A5046465689 @default.
- W4380449712 creator A5054519180 @default.
- W4380449712 creator A5054584536 @default.
- W4380449712 creator A5080601227 @default.
- W4380449712 date "2023-06-13" @default.
- W4380449712 modified "2023-10-04" @default.
- W4380449712 title "Development of <i>meso</i>-Five-Membered Heterocycle BODIPY-Based AIE Fluorescent Probes for Dual-Organelle Viscosity Imaging" @default.
- W4380449712 cites W1988067945 @default.
- W4380449712 cites W1991421234 @default.
- W4380449712 cites W1997855068 @default.
- W4380449712 cites W2000280997 @default.
- W4380449712 cites W2035599820 @default.
- W4380449712 cites W2051865795 @default.
- W4380449712 cites W2135708770 @default.
- W4380449712 cites W2551537647 @default.
- W4380449712 cites W2605992004 @default.
- W4380449712 cites W2794833744 @default.
- W4380449712 cites W2939116057 @default.
- W4380449712 cites W2955267231 @default.
- W4380449712 cites W2985594442 @default.
- W4380449712 cites W2989757583 @default.
- W4380449712 cites W2996029513 @default.
- W4380449712 cites W3009409134 @default.
- W4380449712 cites W3009692479 @default.
- W4380449712 cites W3082555187 @default.
- W4380449712 cites W3094682748 @default.
- W4380449712 cites W3096244939 @default.
- W4380449712 cites W3114893829 @default.
- W4380449712 cites W3117140508 @default.
- W4380449712 cites W3120449704 @default.
- W4380449712 cites W3121039613 @default.
- W4380449712 cites W3127460784 @default.
- W4380449712 cites W3132533817 @default.
- W4380449712 cites W3169038015 @default.
- W4380449712 cites W3199556534 @default.
- W4380449712 cites W3206220531 @default.
- W4380449712 cites W3214226320 @default.
- W4380449712 cites W3216004068 @default.
- W4380449712 cites W4200513614 @default.
- W4380449712 cites W4206624484 @default.
- W4380449712 cites W4210566467 @default.
- W4380449712 cites W4213078445 @default.
- W4380449712 cites W4214534574 @default.
- W4380449712 cites W4221041755 @default.
- W4380449712 cites W4229445920 @default.
- W4380449712 cites W4283324536 @default.
- W4380449712 cites W4283370467 @default.
- W4380449712 cites W4284969588 @default.
- W4380449712 cites W4295135955 @default.
- W4380449712 cites W4304689823 @default.
- W4380449712 cites W4306407012 @default.
- W4380449712 cites W4307841790 @default.
- W4380449712 cites W4309364912 @default.
- W4380449712 cites W4319293935 @default.
- W4380449712 doi "https://doi.org/10.1021/acs.analchem.3c01409" @default.
- W4380449712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37311071" @default.
- W4380449712 hasPublicationYear "2023" @default.
- W4380449712 type Work @default.
- W4380449712 citedByCount "2" @default.
- W4380449712 countsByYear W43804497122023 @default.
- W4380449712 crossrefType "journal-article" @default.
- W4380449712 hasAuthorship W4380449712A5006894242 @default.
- W4380449712 hasAuthorship W4380449712A5022400812 @default.
- W4380449712 hasAuthorship W4380449712A5030507448 @default.
- W4380449712 hasAuthorship W4380449712A5031472196 @default.
- W4380449712 hasAuthorship W4380449712A5032132815 @default.
- W4380449712 hasAuthorship W4380449712A5046465689 @default.
- W4380449712 hasAuthorship W4380449712A5054519180 @default.
- W4380449712 hasAuthorship W4380449712A5054584536 @default.
- W4380449712 hasAuthorship W4380449712A5080601227 @default.
- W4380449712 hasConcept C121332964 @default.
- W4380449712 hasConcept C121745418 @default.
- W4380449712 hasConcept C12554922 @default.
- W4380449712 hasConcept C127172972 @default.
- W4380449712 hasConcept C159985019 @default.
- W4380449712 hasConcept C168240541 @default.
- W4380449712 hasConcept C178790620 @default.
- W4380449712 hasConcept C185592680 @default.
- W4380449712 hasConcept C192562407 @default.
- W4380449712 hasConcept C2778464347 @default.
- W4380449712 hasConcept C2781374752 @default.
- W4380449712 hasConcept C55493867 @default.
- W4380449712 hasConcept C62520636 @default.
- W4380449712 hasConcept C75473681 @default.
- W4380449712 hasConcept C86803240 @default.
- W4380449712 hasConcept C91881484 @default.
- W4380449712 hasConceptScore W4380449712C121332964 @default.
- W4380449712 hasConceptScore W4380449712C121745418 @default.
- W4380449712 hasConceptScore W4380449712C12554922 @default.
- W4380449712 hasConceptScore W4380449712C127172972 @default.
- W4380449712 hasConceptScore W4380449712C159985019 @default.