Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380451810> ?p ?o ?g. }
- W4380451810 endingPage "589" @default.
- W4380451810 startingPage "577" @default.
- W4380451810 abstract "Dopamine-related movement disorders are associated with a loss of visual acuity. Studies have shown that chemical stimulation of the vitamin D3 receptor (VDR) ameliorates movement disorders; however, the chemical stimulation is not effective when there is a deficiency of vitamin A in the cells. In the study, we examine the role of VDR and its interplay with vitamin A in impaired visual function in the dopamine deficit model.Thirty (30) male mice with an average weight of 26 g ± (2) were divided into six group (NS,-D2,-D2 + VD D2 + VD, -D2 + VA, -D2 + (VD + VA) and -D2 + D2 groups). Dopamine deficit models of movement disorders were created using 15 mg/kg of haloperidol (-D2) injected intraperitoneally daily for 21 days. In the -D2 + (VD + VA) group, 800 IU/day of vitamin D3 (VD) and 1000 IU/day of vitamin A were concurrently used, while in the -D2 + D2 group, bromocriptine (+D2) was used as the standard treatment of the model. At the end of the treatment phase, the animals were subjected to visual water box test for visual acuity. The level of oxidative stress was measured using Superoxide dismutase (SOD) and malondialdehyde (MDA) in the retina and visual cortex. The level of cytotoxicity in these tissues was measured using Lactate dehydrogenase (LDH) assay, while the structural integrity of these tissues was assessed using a light microscope by assessing slide mounted sections that were stained with haematoxylin and eosin.A significant decline in time taken to reach the escape platform in the visual water box test was observed in the -D2 (p<0.005) and -D2 + D2 (p<0.05) group. In the retina and the visual cortex, a significant increase in LDH, MDA and the density of degenerating neurons was observed in the -D2 and -D2 + D2 groups. LDH level in the retina was also found to be significantly increased in (-D2 + VD, -D2 + VA, -D2 + (VD + VA). A Significant decrease in SOD was found in the retina and visual cortex of -D2 and -D2 + D2 group. In the histology of the retina, thinning of the retina, retinal fold, distortion and retinal detachment were all seen in the -D2 group. These structural alterations were not seen in other groups. Histological hallmarks of degeneration were observed in the visual cortex of the mice from the -D2 (p<0.001), -D2 + D2 (p<0.005) and -D2 + VD (p<0.05) groups only.Dopamine-deficient models of movement disorders are associated with loss of visual functions, especially due to thinning of the retina, retinal fold, retinal detachment, and neurodegeneration in the visual cortex. Supplementation during the development of the model with vitamin D3 and vitamin A prevented the deterioration of the retina and visual cortex by reducing the degree of oxidative stress and cytotoxicity." @default.
- W4380451810 created "2023-06-14" @default.
- W4380451810 creator A5005392743 @default.
- W4380451810 creator A5039250492 @default.
- W4380451810 date "2023-06-15" @default.
- W4380451810 modified "2023-09-27" @default.
- W4380451810 title "Vitamin A and vitamin D3 protect the visual apparatus during the development of dopamine-2 receptor knockout mouse model of Parkinsonism" @default.
- W4380451810 cites W1032629512 @default.
- W4380451810 cites W1522057967 @default.
- W4380451810 cites W1964947593 @default.
- W4380451810 cites W1968791710 @default.
- W4380451810 cites W1974454062 @default.
- W4380451810 cites W2055874717 @default.
- W4380451810 cites W2063324237 @default.
- W4380451810 cites W2063640158 @default.
- W4380451810 cites W2064840454 @default.
- W4380451810 cites W2077251596 @default.
- W4380451810 cites W2094450831 @default.
- W4380451810 cites W2110767684 @default.
- W4380451810 cites W2111464898 @default.
- W4380451810 cites W2137695578 @default.
- W4380451810 cites W2141092500 @default.
- W4380451810 cites W2149502603 @default.
- W4380451810 cites W2207771596 @default.
- W4380451810 cites W2293027304 @default.
- W4380451810 cites W2401820359 @default.
- W4380451810 cites W2471889184 @default.
- W4380451810 cites W2533190594 @default.
- W4380451810 cites W2535730691 @default.
- W4380451810 cites W2568082326 @default.
- W4380451810 cites W2621094433 @default.
- W4380451810 cites W2639231993 @default.
- W4380451810 cites W2728593064 @default.
- W4380451810 cites W2760845244 @default.
- W4380451810 cites W2772342780 @default.
- W4380451810 cites W2789018622 @default.
- W4380451810 cites W2802099125 @default.
- W4380451810 cites W2805364235 @default.
- W4380451810 cites W2885054582 @default.
- W4380451810 cites W2921691260 @default.
- W4380451810 cites W2954780780 @default.
- W4380451810 cites W2967214863 @default.
- W4380451810 cites W2969573657 @default.
- W4380451810 cites W2997812397 @default.
- W4380451810 cites W3043742469 @default.
- W4380451810 cites W3082730647 @default.
- W4380451810 cites W3084429690 @default.
- W4380451810 cites W3092543387 @default.
- W4380451810 cites W3110198082 @default.
- W4380451810 cites W3117101435 @default.
- W4380451810 cites W4230872407 @default.
- W4380451810 cites W4285585024 @default.
- W4380451810 cites W2031354526 @default.
- W4380451810 doi "https://doi.org/10.1515/jcim-2023-0053" @default.
- W4380451810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37311120" @default.
- W4380451810 hasPublicationYear "2023" @default.
- W4380451810 type Work @default.
- W4380451810 citedByCount "0" @default.
- W4380451810 crossrefType "journal-article" @default.
- W4380451810 hasAuthorship W4380451810A5005392743 @default.
- W4380451810 hasAuthorship W4380451810A5039250492 @default.
- W4380451810 hasConcept C124490489 @default.
- W4380451810 hasConcept C126322002 @default.
- W4380451810 hasConcept C134018914 @default.
- W4380451810 hasConcept C179639408 @default.
- W4380451810 hasConcept C185592680 @default.
- W4380451810 hasConcept C2776151105 @default.
- W4380451810 hasConcept C2776940978 @default.
- W4380451810 hasConcept C2778401633 @default.
- W4380451810 hasConcept C44208683 @default.
- W4380451810 hasConcept C513476851 @default.
- W4380451810 hasConcept C71924100 @default.
- W4380451810 hasConceptScore W4380451810C124490489 @default.
- W4380451810 hasConceptScore W4380451810C126322002 @default.
- W4380451810 hasConceptScore W4380451810C134018914 @default.
- W4380451810 hasConceptScore W4380451810C179639408 @default.
- W4380451810 hasConceptScore W4380451810C185592680 @default.
- W4380451810 hasConceptScore W4380451810C2776151105 @default.
- W4380451810 hasConceptScore W4380451810C2776940978 @default.
- W4380451810 hasConceptScore W4380451810C2778401633 @default.
- W4380451810 hasConceptScore W4380451810C44208683 @default.
- W4380451810 hasConceptScore W4380451810C513476851 @default.
- W4380451810 hasConceptScore W4380451810C71924100 @default.
- W4380451810 hasIssue "3" @default.
- W4380451810 hasLocation W43804518101 @default.
- W4380451810 hasLocation W43804518102 @default.
- W4380451810 hasOpenAccess W4380451810 @default.
- W4380451810 hasPrimaryLocation W43804518101 @default.
- W4380451810 hasRelatedWork W1979059193 @default.
- W4380451810 hasRelatedWork W2015327999 @default.
- W4380451810 hasRelatedWork W2034255477 @default.
- W4380451810 hasRelatedWork W2037727994 @default.
- W4380451810 hasRelatedWork W2060828139 @default.
- W4380451810 hasRelatedWork W2062579683 @default.
- W4380451810 hasRelatedWork W2089103608 @default.
- W4380451810 hasRelatedWork W2163744984 @default.
- W4380451810 hasRelatedWork W2171851218 @default.
- W4380451810 hasRelatedWork W2748952813 @default.