FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380479871> ?p ?o ?g. }

• W4380479871 endingPage "1189" @default.
• W4380479871 startingPage "1182" @default.
• W4380479871 abstract "Abstract Background: To develop a breast cancer prediction model for Korean women using published polygenic risk scores (PRS) combined with nongenetic risk factors (NGRF). Methods: Thirteen PRS models generated from single or multiple combinations of the Asian and European PRSs were evaluated among 20,434 Korean women. The AUC and increase in OR per SD were compared for each PRS. The PRSs with the highest predictive power were combined with NGRFs; then, an integrated prediction model was established using the Individualized Coherent Absolute Risk Estimation (iCARE) tool. The absolute breast cancer risk was stratified for 18,142 women with available follow-up data. Results: PRS38_ASN+PRS190_EB, a combination of Asian and European PRSs, had the highest AUC (0.621) among PRSs, with an OR per SD increase of 1.45 (95% confidence interval: 1.31–1.61). Compared with the average risk group (35%–65%), women in the top 5% had a 2.5-fold higher risk of breast cancer. Incorporating NGRFs yielded a modest increase in the AUC of women ages &gt;50 years. For PRS38_ASN+PRS190_EB+NGRF, the average absolute risk was 5.06%. The lifetime absolute risk at age 80 years for women in the top 5% was 9.93%, whereas that of women in the lowest 5% was 2.22%. Women at higher risks were more sensitive to NGRF incorporation. Conclusions: Combined Asian and European PRSs were predictive of breast cancer in Korean women. Our findings support the use of these models for personalized screening and prevention of breast cancer. Impact: Our study provides insights into genetic susceptibility and NGRFs for predicting breast cancer in Korean women." @default.
• W4380479871 created "2023-06-14" @default.
• W4380479871 creator A5005022842 @default.
• W4380479871 creator A5021444852 @default.
• W4380479871 creator A5034392953 @default.
• W4380479871 creator A5040145953 @default.
• W4380479871 creator A5052192039 @default.
• W4380479871 creator A5065878802 @default.
• W4380479871 creator A5081619579 @default.
• W4380479871 date "2023-06-13" @default.
• W4380479871 modified "2023-10-14" @default.
• W4380479871 title "Development of a Breast Cancer Risk Prediction Model Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Korean Women" @default.
• W4380479871 cites W1840074598 @default.
• W4380479871 cites W1905816198 @default.
• W4380479871 cites W2028687339 @default.
• W4380479871 cites W2069525005 @default.
• W4380479871 cites W2083697259 @default.
• W4380479871 cites W2112615743 @default.
• W4380479871 cites W2116709052 @default.
• W4380479871 cites W2125857176 @default.
• W4380479871 cites W2132571149 @default.
• W4380479871 cites W2134145484 @default.
• W4380479871 cites W2135665336 @default.
• W4380479871 cites W2157116692 @default.
• W4380479871 cites W2160524074 @default.
• W4380479871 cites W2182350758 @default.
• W4380479871 cites W2341084900 @default.
• W4380479871 cites W2409847910 @default.
• W4380479871 cites W2510973425 @default.
• W4380479871 cites W2513145707 @default.
• W4380479871 cites W2560481339 @default.
• W4380479871 cites W2587966923 @default.
• W4380479871 cites W2594727603 @default.
• W4380479871 cites W2781651514 @default.
• W4380479871 cites W2783194010 @default.
• W4380479871 cites W2784938069 @default.
• W4380479871 cites W2788346456 @default.
• W4380479871 cites W2794127671 @default.
• W4380479871 cites W2822564837 @default.
• W4380479871 cites W2889646458 @default.
• W4380479871 cites W2890195818 @default.
• W4380479871 cites W2901952863 @default.
• W4380479871 cites W2920792207 @default.
• W4380479871 cites W2994962701 @default.
• W4380479871 cites W2998611043 @default.
• W4380479871 cites W3004839449 @default.
• W4380479871 cites W3008564772 @default.
• W4380479871 cites W3011971918 @default.
• W4380479871 cites W3014697962 @default.
• W4380479871 cites W3024294833 @default.
• W4380479871 cites W3040276841 @default.
• W4380479871 cites W3041635628 @default.
• W4380479871 cites W3047794286 @default.
• W4380479871 cites W4200309006 @default.
• W4380479871 cites W4220701527 @default.
• W4380479871 cites W4251899993 @default.
• W4380479871 doi "https://doi.org/10.1158/1055-9965.epi-23-0064" @default.
• W4380479871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37310812" @default.
• W4380479871 hasPublicationYear "2023" @default.
• W4380479871 type Work @default.
• W4380479871 citedByCount "0" @default.
• W4380479871 crossrefType "journal-article" @default.
• W4380479871 hasAuthorship W4380479871A5005022842 @default.
• W4380479871 hasAuthorship W4380479871A5021444852 @default.
• W4380479871 hasAuthorship W4380479871A5034392953 @default.
• W4380479871 hasAuthorship W4380479871A5040145953 @default.
• W4380479871 hasAuthorship W4380479871A5052192039 @default.
• W4380479871 hasAuthorship W4380479871A5065878802 @default.
• W4380479871 hasAuthorship W4380479871A5081619579 @default.
• W4380479871 hasBestOaLocation W43804798711 @default.
• W4380479871 hasConcept C104317684 @default.
• W4380479871 hasConcept C120195587 @default.
• W4380479871 hasConcept C121608353 @default.
• W4380479871 hasConcept C12174686 @default.
• W4380479871 hasConcept C126322002 @default.
• W4380479871 hasConcept C131872663 @default.
• W4380479871 hasConcept C135763542 @default.
• W4380479871 hasConcept C143998085 @default.
• W4380479871 hasConcept C144024400 @default.
• W4380479871 hasConcept C149923435 @default.
• W4380479871 hasConcept C153209595 @default.
• W4380479871 hasConcept C29456083 @default.
• W4380479871 hasConcept C2993137441 @default.
• W4380479871 hasConcept C38652104 @default.
• W4380479871 hasConcept C41008148 @default.
• W4380479871 hasConcept C44249647 @default.
• W4380479871 hasConcept C530470458 @default.
• W4380479871 hasConcept C55493867 @default.
• W4380479871 hasConcept C71924100 @default.
• W4380479871 hasConcept C86803240 @default.
• W4380479871 hasConceptScore W4380479871C104317684 @default.
• W4380479871 hasConceptScore W4380479871C120195587 @default.
• W4380479871 hasConceptScore W4380479871C121608353 @default.
• W4380479871 hasConceptScore W4380479871C12174686 @default.
• W4380479871 hasConceptScore W4380479871C126322002 @default.
• W4380479871 hasConceptScore W4380479871C131872663 @default.
• W4380479871 hasConceptScore W4380479871C135763542 @default.
• W4380479871 hasConceptScore W4380479871C143998085 @default.

• next