Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380481036> ?p ?o ?g. }
- W4380481036 endingPage "368" @default.
- W4380481036 startingPage "359" @default.
- W4380481036 abstract "The clinical course of essential thrombocythemia (ET) is complicated with thrombosis which significantly impacts patients' mortality. Studies have identified JAK2V617F mutation as an independent risk factor for thrombosis. Circulating extracellular vesicles (EVs) were evaluated in several studies regarding myeloproliferative neoplasms and thrombosis as potential biomarkers. The present study investigates the relationship between JAK2V617F mutation and EVs levels in 119 ET patients. Our analyses revealed that JAK2V617F-positive patients are at a significantly increased risk of thrombosis within five years before the ET diagnosis (hazard ratio [95% CI]: 11.9 [1.7-83.7], P = 0.013), and that JAK2V617F mutation is an independent risk factor for thrombosis at ET diagnosis or during the follow-up (hazard ratio [95% CI]: 3.56 [1.47-8.62], P = 0.005). ET patients have higher levels of platelet-EVs, erythrocyte-EVs and procoagulant activity of EVs than the healthy population. Absolute and relative counts of platelet-EVs are increased in the presence of JAK2V617F mutation (P = 0.018, P = 0.024, respectively). In conclusion, our results support the role of JAK2V617F mutation in the pathogenesis of thrombosis in essential thrombocythemia through enhancing platelet activation." @default.
- W4380481036 created "2023-06-14" @default.
- W4380481036 creator A5007753985 @default.
- W4380481036 creator A5031121132 @default.
- W4380481036 creator A5035586023 @default.
- W4380481036 creator A5065167043 @default.
- W4380481036 creator A5091155004 @default.
- W4380481036 date "2023-09-20" @default.
- W4380481036 modified "2023-09-27" @default.
- W4380481036 title "JAK2V617F mutation and circulating extracellular vesicles in essential thrombocythemia" @default.
- W4380481036 cites W1961179763 @default.
- W4380481036 cites W1964922553 @default.
- W4380481036 cites W1983262956 @default.
- W4380481036 cites W2063343394 @default.
- W4380481036 cites W2067829130 @default.
- W4380481036 cites W2071281057 @default.
- W4380481036 cites W2078389694 @default.
- W4380481036 cites W2089904959 @default.
- W4380481036 cites W2128759209 @default.
- W4380481036 cites W2129969267 @default.
- W4380481036 cites W2133826007 @default.
- W4380481036 cites W2155484175 @default.
- W4380481036 cites W2168236819 @default.
- W4380481036 cites W2314279276 @default.
- W4380481036 cites W2316337534 @default.
- W4380481036 cites W2588674545 @default.
- W4380481036 cites W2594640929 @default.
- W4380481036 cites W2617229378 @default.
- W4380481036 cites W2698253747 @default.
- W4380481036 cites W2735319950 @default.
- W4380481036 cites W2907564353 @default.
- W4380481036 cites W2947677238 @default.
- W4380481036 cites W2952331001 @default.
- W4380481036 cites W3004247023 @default.
- W4380481036 cites W3129246829 @default.
- W4380481036 cites W3132068389 @default.
- W4380481036 cites W3185963978 @default.
- W4380481036 cites W3205845588 @default.
- W4380481036 cites W3206558653 @default.
- W4380481036 cites W4210916875 @default.
- W4380481036 cites W4220969263 @default.
- W4380481036 cites W4245076521 @default.
- W4380481036 cites W4283271244 @default.
- W4380481036 doi "https://doi.org/10.3233/ch-221678" @default.
- W4380481036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37334581" @default.
- W4380481036 hasPublicationYear "2023" @default.
- W4380481036 type Work @default.
- W4380481036 citedByCount "0" @default.
- W4380481036 crossrefType "journal-article" @default.
- W4380481036 hasAuthorship W4380481036A5007753985 @default.
- W4380481036 hasAuthorship W4380481036A5031121132 @default.
- W4380481036 hasAuthorship W4380481036A5035586023 @default.
- W4380481036 hasAuthorship W4380481036A5065167043 @default.
- W4380481036 hasAuthorship W4380481036A5091155004 @default.
- W4380481036 hasConcept C104317684 @default.
- W4380481036 hasConcept C126322002 @default.
- W4380481036 hasConcept C203014093 @default.
- W4380481036 hasConcept C207103383 @default.
- W4380481036 hasConcept C2778837598 @default.
- W4380481036 hasConcept C2780868729 @default.
- W4380481036 hasConcept C2780942790 @default.
- W4380481036 hasConcept C2781057849 @default.
- W4380481036 hasConcept C2908647359 @default.
- W4380481036 hasConcept C2992929900 @default.
- W4380481036 hasConcept C44249647 @default.
- W4380481036 hasConcept C501734568 @default.
- W4380481036 hasConcept C54355233 @default.
- W4380481036 hasConcept C71924100 @default.
- W4380481036 hasConcept C86803240 @default.
- W4380481036 hasConcept C89560881 @default.
- W4380481036 hasConcept C90924648 @default.
- W4380481036 hasConcept C95444343 @default.
- W4380481036 hasConcept C99454951 @default.
- W4380481036 hasConceptScore W4380481036C104317684 @default.
- W4380481036 hasConceptScore W4380481036C126322002 @default.
- W4380481036 hasConceptScore W4380481036C203014093 @default.
- W4380481036 hasConceptScore W4380481036C207103383 @default.
- W4380481036 hasConceptScore W4380481036C2778837598 @default.
- W4380481036 hasConceptScore W4380481036C2780868729 @default.
- W4380481036 hasConceptScore W4380481036C2780942790 @default.
- W4380481036 hasConceptScore W4380481036C2781057849 @default.
- W4380481036 hasConceptScore W4380481036C2908647359 @default.
- W4380481036 hasConceptScore W4380481036C2992929900 @default.
- W4380481036 hasConceptScore W4380481036C44249647 @default.
- W4380481036 hasConceptScore W4380481036C501734568 @default.
- W4380481036 hasConceptScore W4380481036C54355233 @default.
- W4380481036 hasConceptScore W4380481036C71924100 @default.
- W4380481036 hasConceptScore W4380481036C86803240 @default.
- W4380481036 hasConceptScore W4380481036C89560881 @default.
- W4380481036 hasConceptScore W4380481036C90924648 @default.
- W4380481036 hasConceptScore W4380481036C95444343 @default.
- W4380481036 hasConceptScore W4380481036C99454951 @default.
- W4380481036 hasIssue "4" @default.
- W4380481036 hasLocation W43804810361 @default.
- W4380481036 hasLocation W43804810362 @default.
- W4380481036 hasOpenAccess W4380481036 @default.
- W4380481036 hasPrimaryLocation W43804810361 @default.
- W4380481036 hasRelatedWork W1964922553 @default.