Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380483570> ?p ?o ?g. }
- W4380483570 abstract "Abstract Environmental factors may alter the fetal genome to cause metabolic diseases. It is unknown whether embryonic immune cell programming impacts the risk of type 2 diabetes in later life. We demonstrate that transplantation of fetal hematopoietic stem cells (HSCs) made vitamin D deficient in utero induce diabetes in vitamin D-sufficient mice. Vitamin D deficiency epigenetically suppresses Jarid2 expression and activates the Mef2 / PGC1a pathway in HSCs, which persists in recipient bone marrow, resulting in adipose macrophage infiltration. These macrophages secrete miR106-5p, which promotes adipose insulin resistance by repressing PIK3 catalytic and regulatory subunits and down-regulating AKT signaling. Vitamin D-deficient monocytes from human cord blood have comparable Jarid2/Mef2/PGC1a expression changes and secrete miR-106b-5p, causing adipocyte insulin resistance. These findings suggest that vitamin D deficiency during development has epigenetic consequences impacting the systemic metabolic milieu." @default.
- W4380483570 created "2023-06-14" @default.
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- W4380483570 date "2023-06-13" @default.
- W4380483570 modified "2023-10-17" @default.
- W4380483570 title "Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes" @default.
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