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- W4380485746 abstract "<p>(A) Overall, 27 patients had cell-free tumor load (cfTL) detected using tumor-derived sequence alterations, of which 20 patients also had evaluable plasma aneuploidy (PA)-based responses. Comparison between ctDNA responses determined using mutation-based and plasma aneuploidy-based responses in these 20 patients revealed significant concordance (p < 0.001, Fisher’s exact test). (B) Concordance was also observed between complete elimination of cfTL based on tumor-derived sequence alterations and plasma aneuploidy dynamics in these patients (p < 0.001, Fisher’s exact test). For these comparisons, plasma aneuploidy dynamics were assessed using a binarized classification of PA scores (PA score > 4.90 indicative of tumor aneuploidy, PA score <4.90 indicative of normal ploidy): PA undetectable (normal ploidy across all timepoints analyzed), PA response (aneuploidy detected at baseline or T1 sampling followed by a reduction to normal ploidy by final sampling), PA response followed by recrudescence (aneuploidy detected at baseline and final sampling with a reduction to normal ploidy at intermediate timepoints), PA progression (aneuploidy detected across all timepoints analyzed). (C) A logistic regression model combining both mutation-based and aneuploidy-based ctDNA responses in these 20 patients demonstrated that the combination of both sequence and structural dynamics outperformed either metric for the prediction of overall radiographic response (Combined model AUC = 0.90, Sequence alterations AUC = 0.85, Structural Alterations AUC = 0.74). (D-E) Further analyses of molecular responses derived from mutation-based analyses of cfTL changes in 27 patients with evaluable tumor-derived mutation trends demonstrated significant associations with both overall (OS) and progression-free (PFS) survival (log-rank p = 0.02 and p < 0.0001, respectively), independent of treatment modality (Chemotherapy vs immunotherapy-containing regimens). (F-G) cfTL elimination according to mutation-based analyses was also predictive of both OS and PFS (log-rank p = 0.01 and P < 0.0001, respectively). (H-I) Similarly, PA-based ctDNA responses showed significant associations with both OS (p =0.003) and PFS (log-rank p=0.001).</p>" @default.
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- W4380485746 date "2023-06-13" @default.
- W4380485746 modified "2023-09-27" @default.
- W4380485746 title "Fig S5 from Dynamics of Sequence and Structural Cell-Free DNA Landscapes in Small-Cell Lung Cancer" @default.
- W4380485746 doi "https://doi.org/10.1158/1078-0432.23507156" @default.
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