Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380486529> ?p ?o ?g. }
- W4380486529 abstract "Abstract SARS-CoV-2 has the capacity to evolve mutations to escape vaccine-and infection-acquired immunity and antiviral drugs. A variant-agnostic therapeutic agent that protects against severe disease without putting selective pressure on the virus would thus be a valuable biomedical tool. Here, we challenged rhesus macaques with SARS-CoV-2 Delta and simultaneously treated them with aerosolized RBD-62, a protein developed through multiple rounds of in vitro evolution of SARS-CoV-2 RBD to acquire 1000-fold enhanced ACE2 binding affinity. RBD-62 treatment gave equivalent protection in upper and lower airways, a phenomenon not previously observed with clinically approved vaccines. Importantly, RBD-62 did not block the development of memory responses to Delta and did not elicit anti-drug immunity. These data provide proof-of-concept that RBD-62 can prevent severe disease from a highly virulent variant." @default.
- W4380486529 created "2023-06-14" @default.
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- W4380486529 date "2023-06-12" @default.
- W4380486529 modified "2023-09-27" @default.
- W4380486529 title "RBD-based high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways" @default.
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- W4380486529 doi "https://doi.org/10.1101/2023.06.09.544432" @default.