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- W4380486578 abstract "Aggregation of the Tar DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia and likely contributes to disease by loss of nuclear function. Analysis of TDP-43 function in knockout zebrafish identified an endothelial directional migration and hypersprouting phenotype during development prior lethality. In human umbilical vein cells (HUVEC) the loss of TDP-43 leads to hyperbranching. We identified elevated expression of FIBRONECTIN 1 ( FN1 ), the VASCULAR CELL ADHESION MOLECULE 1 ( VCAM1 ), as well as their receptor INTEGRIN α4β1 ( ITGA4B1 ) in HUVEC cells. Importantly, reducing the levels of ITGA4, FN1 , and VCAM1 homologues in the TDP-43 loss-of-function zebrafish rescues the angiogenic defects indicating the conservation of human and zebrafish TDP-43 function during angiogenesis. Our study identifies a novel pathway regulated by TDP-43 important for angiogenesis during development." @default.
- W4380486578 created "2023-06-14" @default.
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- W4380486578 date "2023-06-13" @default.
- W4380486578 modified "2023-10-09" @default.
- W4380486578 title "Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1" @default.
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- W4380486578 doi "https://doi.org/10.3389/fcell.2023.1169962" @default.
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