FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380486579> ?p ?o ?g. }

• W4380486579 endingPage "789" @default.
• W4380486579 startingPage "775" @default.
• W4380486579 abstract "Nociceptive signals are usually transmitted to layer 4 neurons in somatosensory cortex via the spinothalamic-thalamocortical pathway. The layer 5 corticospinal neurons in sensorimotor cortex are reported to receive the output of neurons in superficial layers; and their descending axons innervate the spinal cord to regulate basic sensorimotor functions. Here, we show that a subset of layer 5 neurons receives spinal inputs through a direct spino-cortical circuit bypassing the thalamus, and thus define these neurons as spino-cortical recipient neurons (SCRNs). Morphological studies revealed that the branches from spinal ascending axons formed a kind of disciform structure with the descending axons from SCRNs in the basilar pontine nucleus (BPN). Electron microscopy and calcium imaging further confirmed that the axon terminals from spinal ascending neurons and SCRNs made functional synaptic contacts in the BPN, linking the ascending sensory pathway to the descending motor control pathway. Furthermore, behavioral tests indicated that the spino-cortical connection in the BPN was involved in nociceptive responses. In vivo calcium imaging showed that SCRNs responded to peripheral noxious stimuli faster than neighboring layer 4 cortical neurons in awake mice. Manipulating activities of SCRNs could modulate nociceptive behaviors. Therefore, this direct spino-cortical circuit represents a noncanonical pathway, allowing a fast sensory-motor transition of the brain in response to noxious stimuli." @default.
• W4380486579 created "2023-06-14" @default.
• W4380486579 creator A5000442118 @default.
• W4380486579 creator A5018523502 @default.
• W4380486579 creator A5024534843 @default.
• W4380486579 creator A5026222209 @default.
• W4380486579 creator A5035419929 @default.
• W4380486579 creator A5037458498 @default.
• W4380486579 creator A5042338811 @default.
• W4380486579 creator A5046944254 @default.
• W4380486579 creator A5048957271 @default.
• W4380486579 creator A5055055894 @default.
• W4380486579 creator A5059292272 @default.
• W4380486579 creator A5060706512 @default.
• W4380486579 creator A5062222430 @default.
• W4380486579 creator A5067804978 @default.
• W4380486579 creator A5073568638 @default.
• W4380486579 creator A5088107428 @default.
• W4380486579 date "2023-06-13" @default.
• W4380486579 modified "2023-10-09" @default.
• W4380486579 title "A direct spino-cortical circuit bypassing the thalamus modulates nociception" @default.
• W4380486579 cites W1572757737 @default.
• W4380486579 cites W1934689287 @default.
• W4380486579 cites W1970821249 @default.
• W4380486579 cites W1993085321 @default.
• W4380486579 cites W1997982013 @default.
• W4380486579 cites W1998138279 @default.
• W4380486579 cites W2008466018 @default.
• W4380486579 cites W2023507734 @default.
• W4380486579 cites W2031552297 @default.
• W4380486579 cites W2037652410 @default.
• W4380486579 cites W2057623849 @default.
• W4380486579 cites W2060782881 @default.
• W4380486579 cites W2075715972 @default.
• W4380486579 cites W2078069584 @default.
• W4380486579 cites W2083155456 @default.
• W4380486579 cites W2086012713 @default.
• W4380486579 cites W2087882770 @default.
• W4380486579 cites W2087997331 @default.
• W4380486579 cites W2119432914 @default.
• W4380486579 cites W2143713245 @default.
• W4380486579 cites W2164826784 @default.
• W4380486579 cites W2322389473 @default.
• W4380486579 cites W2335967836 @default.
• W4380486579 cites W2467946152 @default.
• W4380486579 cites W2615685170 @default.
• W4380486579 cites W2781822280 @default.
• W4380486579 cites W2789360989 @default.
• W4380486579 cites W2890125899 @default.
• W4380486579 cites W2892901999 @default.
• W4380486579 cites W2904345154 @default.
• W4380486579 cites W2922311875 @default.
• W4380486579 cites W2929898295 @default.
• W4380486579 cites W2950976066 @default.
• W4380486579 cites W2979981663 @default.
• W4380486579 cites W3100593193 @default.
• W4380486579 cites W3107957236 @default.
• W4380486579 cites W3134557264 @default.
• W4380486579 cites W3191524981 @default.
• W4380486579 cites W3202762561 @default.
• W4380486579 cites W4239749566 @default.
• W4380486579 cites W4291019707 @default.
• W4380486579 cites W4312190896 @default.
• W4380486579 doi "https://doi.org/10.1038/s41422-023-00832-0" @default.
• W4380486579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37311832" @default.
• W4380486579 hasPublicationYear "2023" @default.
• W4380486579 type Work @default.
• W4380486579 citedByCount "1" @default.
• W4380486579 countsByYear W43804865792023 @default.
• W4380486579 crossrefType "journal-article" @default.
• W4380486579 hasAuthorship W4380486579A5000442118 @default.
• W4380486579 hasAuthorship W4380486579A5018523502 @default.
• W4380486579 hasAuthorship W4380486579A5024534843 @default.
• W4380486579 hasAuthorship W4380486579A5026222209 @default.
• W4380486579 hasAuthorship W4380486579A5035419929 @default.
• W4380486579 hasAuthorship W4380486579A5037458498 @default.
• W4380486579 hasAuthorship W4380486579A5042338811 @default.
• W4380486579 hasAuthorship W4380486579A5046944254 @default.
• W4380486579 hasAuthorship W4380486579A5048957271 @default.
• W4380486579 hasAuthorship W4380486579A5055055894 @default.
• W4380486579 hasAuthorship W4380486579A5059292272 @default.
• W4380486579 hasAuthorship W4380486579A5060706512 @default.
• W4380486579 hasAuthorship W4380486579A5062222430 @default.
• W4380486579 hasAuthorship W4380486579A5067804978 @default.
• W4380486579 hasAuthorship W4380486579A5073568638 @default.
• W4380486579 hasAuthorship W4380486579A5088107428 @default.
• W4380486579 hasBestOaLocation W43804865791 @default.
• W4380486579 hasConcept C105702510 @default.
• W4380486579 hasConcept C126322002 @default.
• W4380486579 hasConcept C15490471 @default.
• W4380486579 hasConcept C169760540 @default.
• W4380486579 hasConcept C170493617 @default.
• W4380486579 hasConcept C172497186 @default.
• W4380486579 hasConcept C24998067 @default.
• W4380486579 hasConcept C2776032975 @default.
• W4380486579 hasConcept C2777348757 @default.
• W4380486579 hasConcept C2778222838 @default.
• W4380486579 hasConcept C2778373776 @default.

• next