Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380490153> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W4380490153 endingPage "64" @default.
- W4380490153 startingPage "61" @default.
- W4380490153 abstract "Background: As an immunomodulator, the mycobacterium w (Mw) has improved outcomes for patients suffering from severe sepsis. The traditional route of administration for Mw is intradermal (ID), which is limited to administering 0.1 mL per injection (Inj). The intravenous (IV) route can be an alternative to ID. Aims and objectives: To evaluate the safety and efficacy of Inj Sepsivac® IV in gram-negative sepsis. Materials and methods: Present retrospective observational study was conducted in an intensive care unit (ICU) of tertiary care hospital. The study included 30 consecutive patients with presumed gram-negative sepsis within 48 hours of the first organ dysfunction. Patients received Inj Sepsivac® 0.3 mL diluted in 100 mL normal saline to be given as slow IV infusions over at least 15 minutes, every day for 3 consecutive days. Efficacy was assessed by recording the change in vital parameters, sequential organ failure assessment (SOFA) score, and laboratory investigations. Safety was evaluated by the occurrence of allergic reactions including anaphylaxis, the site of infection, and secondary infection. Each patient was followed up for 14 days from the day of enrolment. Results: Mean age of patients with gram-negative sepsis was 62.67 ± 12.77 years with male preponderance (63.3%). Pneumonia (40.1%) and intraabdominal infections (26.7%) were the most common etiologies of sepsis. A significant improvement in all the vitals and mean SOFA scores was observed from day 2 onward. More than half of the patients required ventilator support [17 (56.7%)], and mortality was observed in 7 (25%) patients. None was reported to have a secondary infection. Laboratory parameters improved and oxygen requirement was reduced postday 4 till the end of treatment from baseline. Conclusion: The IV route of administration was found to be efficacious and safe and allow ease of administration in treating gram-negative sepsis. Further large multicentric randomized trials are required to confirm our findings." @default.
- W4380490153 created "2023-06-14" @default.
- W4380490153 creator A5083978945 @default.
- W4380490153 date "2023-05-01" @default.
- W4380490153 modified "2023-09-30" @default.
- W4380490153 title "Efficacy and Safety of Injection Sepsivac® (Heat-killed Mycobacterium W) in Gram-negative Sepsis administered via an Intravenous Route" @default.
- W4380490153 doi "https://doi.org/10.5005/japi-11001-0221" @default.
- W4380490153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37355821" @default.
- W4380490153 hasPublicationYear "2023" @default.
- W4380490153 type Work @default.
- W4380490153 citedByCount "0" @default.
- W4380490153 crossrefType "journal-article" @default.
- W4380490153 hasAuthorship W4380490153A5083978945 @default.
- W4380490153 hasBestOaLocation W43804901531 @default.
- W4380490153 hasConcept C126322002 @default.
- W4380490153 hasConcept C197934379 @default.
- W4380490153 hasConcept C2776376669 @default.
- W4380490153 hasConcept C2777397205 @default.
- W4380490153 hasConcept C2777465075 @default.
- W4380490153 hasConcept C2777914695 @default.
- W4380490153 hasConcept C2778384902 @default.
- W4380490153 hasConcept C42219234 @default.
- W4380490153 hasConcept C71924100 @default.
- W4380490153 hasConceptScore W4380490153C126322002 @default.
- W4380490153 hasConceptScore W4380490153C197934379 @default.
- W4380490153 hasConceptScore W4380490153C2776376669 @default.
- W4380490153 hasConceptScore W4380490153C2777397205 @default.
- W4380490153 hasConceptScore W4380490153C2777465075 @default.
- W4380490153 hasConceptScore W4380490153C2777914695 @default.
- W4380490153 hasConceptScore W4380490153C2778384902 @default.
- W4380490153 hasConceptScore W4380490153C42219234 @default.
- W4380490153 hasConceptScore W4380490153C71924100 @default.
- W4380490153 hasIssue "05" @default.
- W4380490153 hasLocation W43804901531 @default.
- W4380490153 hasLocation W43804901532 @default.
- W4380490153 hasOpenAccess W4380490153 @default.
- W4380490153 hasPrimaryLocation W43804901531 @default.
- W4380490153 hasRelatedWork W2112525092 @default.
- W4380490153 hasRelatedWork W2227255924 @default.
- W4380490153 hasRelatedWork W2767154288 @default.
- W4380490153 hasRelatedWork W2803523964 @default.
- W4380490153 hasRelatedWork W2943094940 @default.
- W4380490153 hasRelatedWork W3127720795 @default.
- W4380490153 hasRelatedWork W3208571267 @default.
- W4380490153 hasRelatedWork W4239819831 @default.
- W4380490153 hasRelatedWork W4289730976 @default.
- W4380490153 hasRelatedWork W4298141779 @default.
- W4380490153 hasVolume "71" @default.
- W4380490153 isParatext "false" @default.
- W4380490153 isRetracted "false" @default.
- W4380490153 workType "article" @default.