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- W4380534883 endingPage "2475" @default.
- W4380534883 startingPage "2461" @default.
- W4380534883 abstract "Amyotrophic lateral sclerosis (ALS) is believed to be caused by the aggregation of misfolded or mutated superoxide dismutase 1 (SOD1). As there is currently no treatment, research into aggregation inhibitors continues. Based on docking, molecular dynamics (MD) simulations, and experimental observations, we propose that myricetin, a plant flavonoid, can act as a potent anti-amyloidogenic polyphenol against SOD1 aggregation. Our MD simulation results showed that myricetin stabilizes the protein interface, destabilizes the preformed fibril, and decreases the rate of fibril elongation. Myricetin inhibits the aggregation of SOD1 in a dose-dependent manner as shown by the ThT aggregation kinetics curves. Our transmission electron microscopy, dynamic light scattering, and circular dichroism experiments indicate that fewer shorter fibrils have formed. Fluorescence spectroscopy results predict the involvement of a static quenching mechanism characterized by a strong binding between protein and myricetin. Importantly, size exclusion chromatography revealed the potential of myricetin for fibril destabilization and depolymerization. These experimental observations complement the MD results. Thus, myricetin is a potent SOD1 aggregation inhibitor that can reduce the fibril load. Using the structure of myricetin as a reference, it is possible to design more effective therapeutic inhibitors against ALS that prevent the disease and reverse its effects." @default.
- W4380534883 created "2023-06-14" @default.
- W4380534883 creator A5052161031 @default.
- W4380534883 creator A5052608462 @default.
- W4380534883 creator A5068883180 @default.
- W4380534883 date "2023-06-14" @default.
- W4380534883 modified "2023-09-23" @default.
- W4380534883 title "Myricetin: A Potent Anti-Amyloidogenic Polyphenol against Superoxide Dismutase 1 Aggregation" @default.
- W4380534883 cites W1757990252 @default.
- W4380534883 cites W1885567588 @default.
- W4380534883 cites W1923763303 @default.
- W4380534883 cites W1963767682 @default.
- W4380534883 cites W1966886435 @default.
- W4380534883 cites W1976499671 @default.
- W4380534883 cites W1980374511 @default.
- W4380534883 cites W1981597778 @default.
- W4380534883 cites W1987066756 @default.
- W4380534883 cites W1988944126 @default.
- W4380534883 cites W1991493368 @default.
- W4380534883 cites W1997017073 @default.
- W4380534883 cites W2004950164 @default.
- W4380534883 cites W2007035942 @default.
- W4380534883 cites W2011601475 @default.
- W4380534883 cites W2013957919 @default.
- W4380534883 cites W2013962367 @default.
- W4380534883 cites W2014161432 @default.
- W4380534883 cites W2027482274 @default.
- W4380534883 cites W2027501589 @default.
- W4380534883 cites W2034925108 @default.
- W4380534883 cites W2035266068 @default.
- W4380534883 cites W2040022655 @default.
- W4380534883 cites W2043079451 @default.
- W4380534883 cites W2044172327 @default.
- W4380534883 cites W2046609814 @default.
- W4380534883 cites W2069869463 @default.
- W4380534883 cites W2070198494 @default.
- W4380534883 cites W2071055678 @default.
- W4380534883 cites W2071242789 @default.
- W4380534883 cites W2074473216 @default.
- W4380534883 cites W2080751623 @default.
- W4380534883 cites W2095256839 @default.
- W4380534883 cites W2096386031 @default.
- W4380534883 cites W2097546936 @default.
- W4380534883 cites W2101099825 @default.
- W4380534883 cites W2105103540 @default.
- W4380534883 cites W2105668062 @default.
- W4380534883 cites W2106140689 @default.
- W4380534883 cites W2110580010 @default.
- W4380534883 cites W2120487488 @default.
- W4380534883 cites W2127769185 @default.
- W4380534883 cites W2132629607 @default.
- W4380534883 cites W2135732933 @default.
- W4380534883 cites W2145003993 @default.
- W4380534883 cites W2147993766 @default.
- W4380534883 cites W2149428117 @default.
- W4380534883 cites W2157076525 @default.
- W4380534883 cites W2158907165 @default.
- W4380534883 cites W2166155593 @default.
- W4380534883 cites W2169678694 @default.
- W4380534883 cites W2221151760 @default.
- W4380534883 cites W2239100375 @default.
- W4380534883 cites W2295890540 @default.
- W4380534883 cites W2309333134 @default.
- W4380534883 cites W2325198121 @default.
- W4380534883 cites W2329822097 @default.
- W4380534883 cites W2404280981 @default.
- W4380534883 cites W2426405958 @default.
- W4380534883 cites W2521166789 @default.
- W4380534883 cites W2618318632 @default.
- W4380534883 cites W2724214586 @default.
- W4380534883 cites W2740121245 @default.
- W4380534883 cites W2794635548 @default.
- W4380534883 cites W2794773520 @default.
- W4380534883 cites W2810955037 @default.
- W4380534883 cites W2895946932 @default.
- W4380534883 cites W2898423574 @default.
- W4380534883 cites W2902666895 @default.
- W4380534883 cites W2922133186 @default.
- W4380534883 cites W2983633868 @default.
- W4380534883 cites W2999046204 @default.
- W4380534883 cites W3003506460 @default.
- W4380534883 cites W3013179442 @default.
- W4380534883 cites W3022417000 @default.
- W4380534883 cites W3085914582 @default.
- W4380534883 cites W3094640617 @default.
- W4380534883 cites W3127602688 @default.
- W4380534883 cites W3129989893 @default.
- W4380534883 cites W3131690884 @default.
- W4380534883 cites W3162404124 @default.
- W4380534883 cites W3214989221 @default.
- W4380534883 cites W4205089129 @default.
- W4380534883 cites W4213308675 @default.
- W4380534883 cites W4225300792 @default.
- W4380534883 cites W4236383269 @default.
- W4380534883 cites W4248544631 @default.
- W4380534883 cites W4283018413 @default.
- W4380534883 cites W4295563270 @default.
- W4380534883 cites W4319656951 @default.