Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380536319> ?p ?o ?g. }
- W4380536319 abstract "Abstract Schizophrenia phenotypes are suggestive of impaired cortical plasticity in the disease, but the mechanisms of these deficits are unknown. Genomic association studies have implicated a large number of genes that regulate neuromodulation and plasticity, indicating that the plasticity deficits have a genetic origin. Here, we used biochemically detailed computational modelling of post-synaptic plasticity to investigate how schizophrenia-associated genes regulate long-term potentiation (LTP) and depression (LTD). We combined our model with data from post-mortem mRNA expression studies (CommonMind gene-expression datasets) to assess the consequences of altered expression of plasticity-regulating genes for the amplitude of LTP and LTD. Our results show that the expression alterations observed post mortem , especially those in anterior cingulate cortex, lead to impaired PKA-pathway-mediated LTP in synapses containing GluR1 receptors. We validated these findings using a genotyped EEG dataset where polygenic risk scores for synaptic and ion channel-encoding genes as well as modulation of visual evoked potentials (VEP) were determined for 286 healthy controls. Our results provide a possible genetic mechanism for plasticity impairments in schizophrenia, which can lead to improved understanding and, ultimately, treatment of the disorder." @default.
- W4380536319 created "2023-06-14" @default.
- W4380536319 creator A5008868538 @default.
- W4380536319 creator A5010991301 @default.
- W4380536319 creator A5011473530 @default.
- W4380536319 creator A5032715711 @default.
- W4380536319 creator A5036872905 @default.
- W4380536319 creator A5042733882 @default.
- W4380536319 creator A5052826567 @default.
- W4380536319 creator A5054745889 @default.
- W4380536319 creator A5064324947 @default.
- W4380536319 creator A5089159864 @default.
- W4380536319 date "2023-06-14" @default.
- W4380536319 modified "2023-09-23" @default.
- W4380536319 title "Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modelling" @default.
- W4380536319 cites W1512908939 @default.
- W4380536319 cites W1575693343 @default.
- W4380536319 cites W1586514729 @default.
- W4380536319 cites W1921182138 @default.
- W4380536319 cites W1926511387 @default.
- W4380536319 cites W1964849150 @default.
- W4380536319 cites W1966408207 @default.
- W4380536319 cites W1968946845 @default.
- W4380536319 cites W1970707135 @default.
- W4380536319 cites W1982950553 @default.
- W4380536319 cites W1985405412 @default.
- W4380536319 cites W1987832351 @default.
- W4380536319 cites W1988079689 @default.
- W4380536319 cites W1990676315 @default.
- W4380536319 cites W1991287694 @default.
- W4380536319 cites W1991767840 @default.
- W4380536319 cites W1992507868 @default.
- W4380536319 cites W1992639451 @default.
- W4380536319 cites W1994681591 @default.
- W4380536319 cites W1996456984 @default.
- W4380536319 cites W1997896308 @default.
- W4380536319 cites W1997950587 @default.
- W4380536319 cites W1998074810 @default.
- W4380536319 cites W1998679999 @default.
- W4380536319 cites W2000966565 @default.
- W4380536319 cites W2015144766 @default.
- W4380536319 cites W2015347535 @default.
- W4380536319 cites W2018578596 @default.
- W4380536319 cites W2019035666 @default.
- W4380536319 cites W2019634432 @default.
- W4380536319 cites W2022047741 @default.
- W4380536319 cites W2023721895 @default.
- W4380536319 cites W2025542749 @default.
- W4380536319 cites W2034137610 @default.
- W4380536319 cites W2035835440 @default.
- W4380536319 cites W2036380282 @default.
- W4380536319 cites W2036597812 @default.
- W4380536319 cites W2038458899 @default.
- W4380536319 cites W2039547082 @default.
- W4380536319 cites W2040709031 @default.
- W4380536319 cites W2041165019 @default.
- W4380536319 cites W2052415426 @default.
- W4380536319 cites W2052791472 @default.
- W4380536319 cites W2055630164 @default.
- W4380536319 cites W2056678372 @default.
- W4380536319 cites W2060884332 @default.
- W4380536319 cites W2062520414 @default.
- W4380536319 cites W2066680913 @default.
- W4380536319 cites W2078108567 @default.
- W4380536319 cites W2079772448 @default.
- W4380536319 cites W2084701651 @default.
- W4380536319 cites W2090894059 @default.
- W4380536319 cites W2094727853 @default.
- W4380536319 cites W2097331211 @default.
- W4380536319 cites W2097860097 @default.
- W4380536319 cites W2098146251 @default.
- W4380536319 cites W2101357408 @default.
- W4380536319 cites W2104049715 @default.
- W4380536319 cites W2107239850 @default.
- W4380536319 cites W2109970693 @default.
- W4380536319 cites W2114715394 @default.
- W4380536319 cites W2123153451 @default.
- W4380536319 cites W2127198126 @default.
- W4380536319 cites W2127205775 @default.
- W4380536319 cites W2128519053 @default.
- W4380536319 cites W2130851537 @default.
- W4380536319 cites W2133667940 @default.
- W4380536319 cites W2134750491 @default.
- W4380536319 cites W2139330109 @default.
- W4380536319 cites W2146333273 @default.
- W4380536319 cites W2147609901 @default.
- W4380536319 cites W2148129999 @default.
- W4380536319 cites W2154748059 @default.
- W4380536319 cites W2160524599 @default.
- W4380536319 cites W2161262899 @default.
- W4380536319 cites W2162107781 @default.
- W4380536319 cites W2162552344 @default.
- W4380536319 cites W2163883777 @default.
- W4380536319 cites W2167555395 @default.
- W4380536319 cites W2170926238 @default.
- W4380536319 cites W2179438025 @default.
- W4380536319 cites W2181445041 @default.
- W4380536319 cites W2191292005 @default.
- W4380536319 cites W2219957567 @default.
- W4380536319 cites W2315726838 @default.