FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380538074> ?p ?o ?g. }

• W4380538074 abstract "Abstract Background IDH-wildtype glioblastoma (GBM) is a highly malignant primary brain tumor with a median survival of 15 months after standard of care, which highlights the need for improved therapy. Personalized combination therapy has shown to be successful in many other tumor types and could be beneficial for GBM patients. Methods We performed the largest drug combination screen to date in GBM, using a high-throughput effort where we selected 90 drug combinations for their activity onto 25 patient-derived GBM cultures. 43 drug combinations were selected for interaction analysis based on their monotherapy efficacy and were tested in a short-term (3 days) as well as long-term (18 days) assay. Synergy was assessed using dose-equivalence and multiplicative survival metrics. Results We observed a consistent synergistic interaction for 15 out of 43 drug combinations on patient-derived GBM cultures. From these combinations, 11 out of 15 drug combinations showed a longitudinal synergistic effect on GBM cultures. The highest synergies were observed in the drug combinations Lapatinib with Thapsigargin and Lapatinib with Obatoclax Mesylate, both targeting epidermal growth factor receptor and affecting the apoptosis pathway. To further elaborate on the apoptosis cascade, we investigated other, more clinically relevant, apoptosis inducers and observed a strong synergistic effect while combining Venetoclax (BCL targeting) and AZD5991 (MCL1 targeting). Conclusions Overall, we have identified via a high-throughput drug screening several new treatment strategies for GBM. Moreover, an exceptionally strong synergistic interaction was discovered between kinase targeting and apoptosis induction which is suitable for further clinical evaluation as multi-targeted combination therapy." @default.
• W4380538074 created "2023-06-14" @default.
• W4380538074 creator A5028006298 @default.
• W4380538074 creator A5037248394 @default.
• W4380538074 creator A5039197490 @default.
• W4380538074 creator A5046143607 @default.
• W4380538074 creator A5050961926 @default.
• W4380538074 creator A5051927182 @default.
• W4380538074 creator A5052017818 @default.
• W4380538074 creator A5052098442 @default.
• W4380538074 creator A5052578730 @default.
• W4380538074 creator A5053700204 @default.
• W4380538074 creator A5066774152 @default.
• W4380538074 creator A5068961325 @default.
• W4380538074 creator A5075229234 @default.
• W4380538074 creator A5090542202 @default.
• W4380538074 creator A5092160131 @default.
• W4380538074 date "2023-01-01" @default.
• W4380538074 modified "2023-10-18" @default.
• W4380538074 title "Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies" @default.
• W4380538074 cites W1578932543 @default.
• W4380538074 cites W1696775091 @default.
• W4380538074 cites W1823184461 @default.
• W4380538074 cites W1963558982 @default.
• W4380538074 cites W2040176056 @default.
• W4380538074 cites W2060737851 @default.
• W4380538074 cites W2061061337 @default.
• W4380538074 cites W2096287682 @default.
• W4380538074 cites W2137240394 @default.
• W4380538074 cites W2148977460 @default.
• W4380538074 cites W2158681922 @default.
• W4380538074 cites W2165871546 @default.
• W4380538074 cites W2320205132 @default.
• W4380538074 cites W2320523858 @default.
• W4380538074 cites W2518086895 @default.
• W4380538074 cites W2603616104 @default.
• W4380538074 cites W2753385986 @default.
• W4380538074 cites W2773092701 @default.
• W4380538074 cites W2808653175 @default.
• W4380538074 cites W2811300508 @default.
• W4380538074 cites W2903289999 @default.
• W4380538074 cites W2905070646 @default.
• W4380538074 cites W2905302554 @default.
• W4380538074 cites W2917986762 @default.
• W4380538074 cites W2947284548 @default.
• W4380538074 cites W2982537632 @default.
• W4380538074 cites W2989954637 @default.
• W4380538074 cites W2997979341 @default.
• W4380538074 cites W3011191145 @default.
• W4380538074 cites W3014482292 @default.
• W4380538074 cites W3016155143 @default.
• W4380538074 cites W3033204916 @default.
• W4380538074 cites W3040435169 @default.
• W4380538074 cites W3135868814 @default.
• W4380538074 cites W3164555487 @default.
• W4380538074 cites W3165143074 @default.
• W4380538074 cites W3165328870 @default.
• W4380538074 cites W4210837388 @default.
• W4380538074 cites W4211148923 @default.
• W4380538074 cites W4211220688 @default.
• W4380538074 cites W4233700112 @default.
• W4380538074 doi "https://doi.org/10.1093/noajnl/vdad073" @default.
• W4380538074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37455945" @default.
• W4380538074 hasPublicationYear "2023" @default.
• W4380538074 type Work @default.
• W4380538074 citedByCount "0" @default.
• W4380538074 crossrefType "journal-article" @default.
• W4380538074 hasAuthorship W4380538074A5028006298 @default.
• W4380538074 hasAuthorship W4380538074A5037248394 @default.
• W4380538074 hasAuthorship W4380538074A5039197490 @default.
• W4380538074 hasAuthorship W4380538074A5046143607 @default.
• W4380538074 hasAuthorship W4380538074A5050961926 @default.
• W4380538074 hasAuthorship W4380538074A5051927182 @default.
• W4380538074 hasAuthorship W4380538074A5052017818 @default.
• W4380538074 hasAuthorship W4380538074A5052098442 @default.
• W4380538074 hasAuthorship W4380538074A5052578730 @default.
• W4380538074 hasAuthorship W4380538074A5053700204 @default.
• W4380538074 hasAuthorship W4380538074A5066774152 @default.
• W4380538074 hasAuthorship W4380538074A5068961325 @default.
• W4380538074 hasAuthorship W4380538074A5075229234 @default.
• W4380538074 hasAuthorship W4380538074A5090542202 @default.
• W4380538074 hasAuthorship W4380538074A5092160131 @default.
• W4380538074 hasBestOaLocation W43805380741 @default.
• W4380538074 hasConcept C121608353 @default.
• W4380538074 hasConcept C126322002 @default.
• W4380538074 hasConcept C143998085 @default.
• W4380538074 hasConcept C170493617 @default.
• W4380538074 hasConcept C190283241 @default.
• W4380538074 hasConcept C2777329042 @default.
• W4380538074 hasConcept C2779438470 @default.
• W4380538074 hasConcept C2779786085 @default.
• W4380538074 hasConcept C2780035454 @default.
• W4380538074 hasConcept C502942594 @default.
• W4380538074 hasConcept C530470458 @default.
• W4380538074 hasConcept C55493867 @default.
• W4380538074 hasConcept C71924100 @default.
• W4380538074 hasConcept C86803240 @default.
• W4380538074 hasConcept C98274493 @default.
• W4380538074 hasConceptScore W4380538074C121608353 @default.
• W4380538074 hasConceptScore W4380538074C126322002 @default.

• next