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- W4380574700 abstract "Breast cancer (BC) is a global health concern and the leading cause of cancerous death among women across the world, BC has been characterized by fresh lump in the breast or underarm (armpit), thickened or swollen. Worldwide estimated 9.6 million deaths in 2018–2019. Numerous drugs have been approved by FDA for BC treatment but showed numerous adverse effects like bioavailability issues, selectivity issues, and toxicity issues. Therefore, there is an immediate need to develop new molecules that are non-toxic and more efficient for treating cancer. Isoxazole derivatives have gained popularity over the few years due to their effective antitumor potential. These derivatives work against cancer by inhibiting the thymidylate enzyme, inducing apoptosis, inhibiting tubulin polymerization, protein kinase inhibition, and aromatase inhibition. In this study, we have concentrated on the isoxazole derivative with structure–activity relationship study, various synthesis techniques, mechanism of action, docking, and simulation studies pertaining to BC receptors. Hence the development of isoxazole derivatives with improved therapeutic efficacy will inspire further progress in improving human health.Communicated by Ramaswamy H. Sarma" @default.
- W4380574700 created "2023-06-15" @default.
- W4380574700 creator A5025855311 @default.
- W4380574700 creator A5067293647 @default.
- W4380574700 creator A5075735701 @default.
- W4380574700 creator A5076742522 @default.
- W4380574700 date "2023-06-14" @default.
- W4380574700 modified "2023-09-23" @default.
- W4380574700 title "A review of synthetic strategy, SAR, docking, simulation studies, and mechanism of action of isoxazole derivatives as anticancer agents" @default.
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- W4380574700 doi "https://doi.org/10.1080/07391102.2023.2220819" @default.
- W4380574700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37315986" @default.
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