Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380576845> ?p ?o ?g. }
- W4380576845 abstract "Coordinated regulation of gene activity by transcriptional and translational mechanisms poise stem cells for a timely cell-state transition during differentiation. Although important for all stemness-to-differentiation transitions, mechanistic understanding of the fine-tuning of gene transcription is lacking due to the compensatory effect of translational control. We used intermediate neural progenitor (INP) identity commitment to define the mechanisms that fine-tune stemness gene transcription in fly neural stem cells (neuroblasts). We demonstrate that the transcription factor Fruitless C (Fru C ) binds cis -regulatory elements of most genes uniquely transcribed in neuroblasts. Loss of fru C function alone has no effect on INP commitment but drives INP dedifferentiation when translational control is reduced. Fru C negatively regulates gene expression by promoting low-level enrichment of the repressive histone mark H3K27me3 in gene cis -regulatory regions. Identical to fru C loss-of-function, reducing Polycomb Repressive Complex 2 activity increases stemness gene activity. We propose low-level H3K27me3 enrichment fine-tunes gene transcription in stem cells, a mechanism likely conserved from flies to humans." @default.
- W4380576845 created "2023-06-15" @default.
- W4380576845 creator A5003735811 @default.
- W4380576845 creator A5022969344 @default.
- W4380576845 creator A5038766387 @default.
- W4380576845 creator A5040631498 @default.
- W4380576845 creator A5053548185 @default.
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- W4380576845 creator A5088302274 @default.
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- W4380576845 creator A5092162735 @default.
- W4380576845 date "2023-06-14" @default.
- W4380576845 modified "2023-09-27" @default.
- W4380576845 title "Low-level repressive histone marks fine-tune gene transcription in neural stem cells" @default.
- W4380576845 cites W1606301060 @default.
- W4380576845 cites W1771253106 @default.
- W4380576845 cites W1968674209 @default.
- W4380576845 cites W1972776308 @default.
- W4380576845 cites W1974908487 @default.
- W4380576845 cites W1977896930 @default.
- W4380576845 cites W1981336776 @default.
- W4380576845 cites W1981340767 @default.
- W4380576845 cites W1993115402 @default.
- W4380576845 cites W2001515992 @default.
- W4380576845 cites W2002404131 @default.
- W4380576845 cites W2002602524 @default.
- W4380576845 cites W2005613383 @default.
- W4380576845 cites W2007086703 @default.
- W4380576845 cites W2012118125 @default.
- W4380576845 cites W2014677321 @default.
- W4380576845 cites W2017840637 @default.
- W4380576845 cites W2021341670 @default.
- W4380576845 cites W2026998481 @default.
- W4380576845 cites W2039289317 @default.
- W4380576845 cites W2041209382 @default.
- W4380576845 cites W2049520895 @default.
- W4380576845 cites W2049579790 @default.
- W4380576845 cites W2049598074 @default.
- W4380576845 cites W2051444055 @default.
- W4380576845 cites W2054158156 @default.
- W4380576845 cites W2058735778 @default.
- W4380576845 cites W2065387800 @default.
- W4380576845 cites W2066483986 @default.
- W4380576845 cites W2073201794 @default.
- W4380576845 cites W2079553739 @default.
- W4380576845 cites W2085184586 @default.
- W4380576845 cites W2088539039 @default.
- W4380576845 cites W2096569072 @default.
- W4380576845 cites W2098313605 @default.
- W4380576845 cites W2102619694 @default.
- W4380576845 cites W2107227145 @default.
- W4380576845 cites W2108234281 @default.
- W4380576845 cites W2108663844 @default.
- W4380576845 cites W2110205681 @default.
- W4380576845 cites W2112137379 @default.
- W4380576845 cites W2114104545 @default.
- W4380576845 cites W2120525124 @default.
- W4380576845 cites W2124042578 @default.
- W4380576845 cites W2127184995 @default.
- W4380576845 cites W2127197885 @default.
- W4380576845 cites W2127262898 @default.
- W4380576845 cites W2129422654 @default.
- W4380576845 cites W2131751546 @default.
- W4380576845 cites W2137654905 @default.
- W4380576845 cites W2138207763 @default.
- W4380576845 cites W2141236652 @default.
- W4380576845 cites W2146648681 @default.
- W4380576845 cites W2148120557 @default.
- W4380576845 cites W2150968671 @default.
- W4380576845 cites W2152642445 @default.
- W4380576845 cites W2152660732 @default.
- W4380576845 cites W2154262793 @default.
- W4380576845 cites W2155484721 @default.
- W4380576845 cites W2158375643 @default.
- W4380576845 cites W2159571381 @default.
- W4380576845 cites W2160680240 @default.
- W4380576845 cites W2161742674 @default.
- W4380576845 cites W2166643977 @default.
- W4380576845 cites W2167279371 @default.
- W4380576845 cites W2170551349 @default.
- W4380576845 cites W2171260083 @default.
- W4380576845 cites W2171808845 @default.
- W4380576845 cites W2219121912 @default.
- W4380576845 cites W2288694327 @default.
- W4380576845 cites W2315765031 @default.
- W4380576845 cites W2336566078 @default.
- W4380576845 cites W2341539131 @default.
- W4380576845 cites W2497048512 @default.
- W4380576845 cites W2509957998 @default.
- W4380576845 cites W2523115422 @default.
- W4380576845 cites W2594706714 @default.
- W4380576845 cites W2620197790 @default.
- W4380576845 cites W2706145802 @default.
- W4380576845 cites W2739532739 @default.
- W4380576845 cites W2745995564 @default.
- W4380576845 cites W2753122043 @default.
- W4380576845 cites W2767642029 @default.
- W4380576845 cites W2771292125 @default.
- W4380576845 cites W2779538387 @default.
- W4380576845 cites W2789219702 @default.