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• W4380589435 abstract "Objective We aimed to determine the epidermal growth factor receptor ( EGFR ) mutation status and treatment survival of patients with stage IV lung adenocarcinoma living in the Ordos area of Inner Mongolia, China. Methods EGFR testing and first-line tyrosine kinase inhibitor (TKI) treatment rates of patients with stage IV lung adenocarcinoma were analyzed from June 2012 to June 2016. Kaplan-Meier survival curves were constructed to compare patients who received different treatment strategies and those harboring different EGFR mutation statuses. Results EGFR testing and mutation rates were 65.60% and 52.90%, respectively, and improved continuously from June 2012 to June 2016. Among patients with EGFR mutations, 38.9% had EGFR 19 del, 48.2% had L858R, 4.2% had co-existing mutations in exons 19 and 21, and 8.4% had uncommon mutations. The median overall survival (OS) was 29.5, 26.5, and 16.0 months for patients receiving both TKI and chemotherapy, TKI alone, and chemotherapy alone, respectively ( P = 0.047). The OS was 26.5 and 30.0 months for patients harboring EGFR 19 del and L858R mutations, respectively ( P = 0.096). Conclusion The high OS rates of stage IV lung adenocarcinoma patients living in the Ordos area may be attributed to continuous improvements in EGFR testing and first-line TKI treatment rates. In the era of TKIs, chemotherapy for increasing OS times should be emphasized." @default.
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• W4380589435 date "2018-08-01" @default.
• W4380589435 modified "2023-10-06" @default.
• W4380589435 title "Treatment and survival status of patients with <i>EGFR</i> mutation-positive stage IV lung adenocarcinoma: five-year follow-up results in the Ordos Area of Inner Mongolia, China" @default.
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• W4380589435 doi "https://doi.org/10.1007/s10330-018-0281-1" @default.
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