Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380605855> ?p ?o ?g. }
- W4380605855 abstract "Anthracyclines are a class of widely prescribed anticancer drugs that disrupt chromatin by intercalating into DNA and enhancing nucleosome turnover. To understand the molecular consequences of anthracycline-mediated chromatin disruption, we used Cleavage Under Targets and Tagmentation (CUT&Tag) to profile RNA polymerase II during anthracycline treatment in Drosophila cells. We observed that treatment with the anthracycline aclarubicin leads to elevated levels of RNA polymerase II and changes in chromatin accessibility. We found that promoter proximity and orientation affect chromatin changes during aclarubicin treatment, as closely spaced divergent promoter pairs show greater chromatin changes when compared to codirectionally oriented tandem promoters. We also found that aclarubicin treatment changes the distribution of noncanonical DNA G-quadruplex structures both at promoters and at G-rich pericentromeric repeats. Our work suggests that the cancer-killing activity of aclarubicin is driven by the disruption of nucleosomes and RNA polymerase II." @default.
- W4380605855 created "2023-06-15" @default.
- W4380605855 creator A5017238073 @default.
- W4380605855 creator A5042988141 @default.
- W4380605855 creator A5058508433 @default.
- W4380605855 creator A5066603492 @default.
- W4380605855 date "2023-06-16" @default.
- W4380605855 modified "2023-10-03" @default.
- W4380605855 title "Aclarubicin stimulates RNA polymerase II elongation at closely spaced divergent promoters" @default.
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