FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380628395> ?p ?o ?g. }

• W4380628395 endingPage "e0011224" @default.
• W4380628395 startingPage "e0011224" @default.
• W4380628395 abstract "Traditionally, health ministries implement mass drug administration programmes for each neglected tropical disease (NTD) as separate and distinct campaigns. Many NTDs have overlapping endemicity suggesting co-administration might improve programme reach and efficiency, helping accelerate progress towards 2030 targets. Safety data are required to support a recommendation to undertake co-administration.We aimed to compile and summarize existing data on co-administration of ivermectin, albendazole and azithromycin, including both data on pharmacokinetic interactions and data from previous experimental and observational studies conducted in NTD-endemic populations. We searched PubMed, Google Scholar, research and conference abstracts, gray literature, and national policy documents. We limited the publication language to English and used a search period from January 1st, 1995 through October 1st, 2022. Search terms were: azithromycin and ivermectin and albendazole, mass drug administration co-administration trials, integrated mass drug administration, mass drug administration safety, pharmacokinetic dynamics, and azithromycin and ivermectin and albendazole. We excluded papers if they did not include data on co-administration of azithromycin and both albendazole and ivermectin, or azithromycin with either albendazole or ivermectin alone.We identified a total of 58 potentially relevant studies. Of these we identified 7 studies relevant to the research question and which met our inclusion criteria. Three papers analyzed pharmacokinetic and pharmacodynamic interactions. No study found evidence of clinically significant drug-drug interactions likely to impact safety or efficacy. Two papers and a conference presentation reported data on the safety of combinations of at least two of the drugs. A field study in Mali suggested the rates of adverse events were similar with combined or separate administration, but was underpowered. A further field study in Papua New Guinea used all three drugs as part of a four-drug regimen also including diethylcarbamazine; in this setting, co-administration appeared safe but there were issues with the consistency in how adverse events were recorded.There are relatively limited data on the safety profile of co-administering ivermectin, albendazole and azithromycin as an integrated regimen for NTDs. Despite the limited amount of data, available evidence suggests that such a strategy is safe with an absence of clinically important drug-drug interactions, no serious adverse events reported and little evidence for an increase in mild adverse events. Integrated MDA may be a viable strategy for national NTD programmes." @default.
• W4380628395 created "2023-06-15" @default.
• W4380628395 creator A5003051173 @default.
• W4380628395 creator A5027811651 @default.
• W4380628395 creator A5038338011 @default.
• W4380628395 creator A5049028027 @default.
• W4380628395 creator A5053554062 @default.
• W4380628395 creator A5057509814 @default.
• W4380628395 creator A5073636405 @default.
• W4380628395 date "2023-06-14" @default.
• W4380628395 modified "2023-09-27" @default.
• W4380628395 title "Pharmacokinetics, feasibility and safety of co-administering azithromycin, albendazole, and ivermectin during mass drug administration: A review" @default.
• W4380628395 cites W1988963904 @default.
• W4380628395 cites W2040137060 @default.
• W4380628395 cites W2059619551 @default.
• W4380628395 cites W2071618337 @default.
• W4380628395 cites W2081438866 @default.
• W4380628395 cites W2089694174 @default.
• W4380628395 cites W2101264978 @default.
• W4380628395 cites W2135242235 @default.
• W4380628395 cites W2165091615 @default.
• W4380628395 cites W2571540049 @default.
• W4380628395 cites W2870426619 @default.
• W4380628395 cites W2891534801 @default.
• W4380628395 cites W2928276993 @default.
• W4380628395 cites W2985177450 @default.
• W4380628395 cites W3024516504 @default.
• W4380628395 cites W3081113369 @default.
• W4380628395 cites W3155707046 @default.
• W4380628395 cites W3205610570 @default.
• W4380628395 cites W3209028929 @default.
• W4380628395 cites W4220704503 @default.
• W4380628395 cites W4247661215 @default.
• W4380628395 cites W4367322124 @default.
• W4380628395 doi "https://doi.org/10.1371/journal.pntd.0011224" @default.
• W4380628395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37315102" @default.
• W4380628395 hasPublicationYear "2023" @default.
• W4380628395 type Work @default.
• W4380628395 citedByCount "0" @default.
• W4380628395 crossrefType "journal-article" @default.
• W4380628395 hasAuthorship W4380628395A5003051173 @default.
• W4380628395 hasAuthorship W4380628395A5027811651 @default.
• W4380628395 hasAuthorship W4380628395A5038338011 @default.
• W4380628395 hasAuthorship W4380628395A5049028027 @default.
• W4380628395 hasAuthorship W4380628395A5053554062 @default.
• W4380628395 hasAuthorship W4380628395A5057509814 @default.
• W4380628395 hasAuthorship W4380628395A5073636405 @default.
• W4380628395 hasBestOaLocation W43806283951 @default.
• W4380628395 hasConcept C112705442 @default.
• W4380628395 hasConcept C141071460 @default.
• W4380628395 hasConcept C2777065887 @default.
• W4380628395 hasConcept C2777499811 @default.
• W4380628395 hasConcept C2778907293 @default.
• W4380628395 hasConcept C2780133432 @default.
• W4380628395 hasConcept C2908647359 @default.
• W4380628395 hasConcept C42972112 @default.
• W4380628395 hasConcept C501593827 @default.
• W4380628395 hasConcept C71924100 @default.
• W4380628395 hasConcept C86803240 @default.
• W4380628395 hasConcept C89423630 @default.
• W4380628395 hasConcept C98274493 @default.
• W4380628395 hasConcept C99454951 @default.
• W4380628395 hasConceptScore W4380628395C112705442 @default.
• W4380628395 hasConceptScore W4380628395C141071460 @default.
• W4380628395 hasConceptScore W4380628395C2777065887 @default.
• W4380628395 hasConceptScore W4380628395C2777499811 @default.
• W4380628395 hasConceptScore W4380628395C2778907293 @default.
• W4380628395 hasConceptScore W4380628395C2780133432 @default.
• W4380628395 hasConceptScore W4380628395C2908647359 @default.
• W4380628395 hasConceptScore W4380628395C42972112 @default.
• W4380628395 hasConceptScore W4380628395C501593827 @default.
• W4380628395 hasConceptScore W4380628395C71924100 @default.
• W4380628395 hasConceptScore W4380628395C86803240 @default.
• W4380628395 hasConceptScore W4380628395C89423630 @default.
• W4380628395 hasConceptScore W4380628395C98274493 @default.
• W4380628395 hasConceptScore W4380628395C99454951 @default.
• W4380628395 hasIssue "6" @default.
• W4380628395 hasLocation W43806283951 @default.
• W4380628395 hasLocation W43806283952 @default.
• W4380628395 hasLocation W43806283953 @default.
• W4380628395 hasOpenAccess W4380628395 @default.
• W4380628395 hasPrimaryLocation W43806283951 @default.
• W4380628395 hasRelatedWork W2101264978 @default.
• W4380628395 hasRelatedWork W2135242235 @default.
• W4380628395 hasRelatedWork W3081113369 @default.
• W4380628395 hasRelatedWork W3209028929 @default.
• W4380628395 hasRelatedWork W4239439442 @default.
• W4380628395 hasRelatedWork W4319811824 @default.
• W4380628395 hasRelatedWork W4321021391 @default.
• W4380628395 hasRelatedWork W4323976981 @default.
• W4380628395 hasRelatedWork W4367322124 @default.
• W4380628395 hasRelatedWork W4380628395 @default.
• W4380628395 hasVolume "17" @default.
• W4380628395 isParatext "false" @default.
• W4380628395 isRetracted "false" @default.
• W4380628395 workType "article" @default.