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- W4380631645 abstract "Colorectal adenocarcinoma (COREAD) is the second most deadly cancer and third most frequently encountered malignancy worldwide. Despite efforts in molecular subtyping and subsequent personalized COREAD treatments, multidisciplinary evidence suggests separating COREAD into colon cancer (COAD) and rectal cancer (READ). This new perspective could improve diagnosis and treatment of both carcinomas. RNA-binding proteins (RBPs), as critical regulators of every hallmark of cancer, could fulfill the need to identify sensitive biomarkers for COAD and READ separately. To detect new RBPs involved in COAD and READ progression, here we used a multidata integration strategy to prioritize tumorigenic RBPs. We analyzed and integrated 1) RBPs genomic and transcriptomic alterations from 488 COAD and 155 READ patients, 2) ∼ 10,000 raw associations between RBPs and cancer genes, 3) ∼ 15,000 immunostainings, and 4) loss-of-function screens performed in 102 COREAD cell lines. Thus, we unraveled new putative roles of NOP56, RBM12, NAT10, FKBP1A, EMG1, and CSE1L in COAD and READ progression. Interestingly, FKBP1A and EMG1 have never been related with any of these carcinomas but presented tumorigenic features in other cancer types. Subsequent survival analyses highlighted the clinical relevance of FKBP1A, NOP56, and NAT10 mRNA expression to predict poor prognosis in COREAD and COAD patients. Further research should be performed to validate their clinical potential and to elucidate their molecular mechanisms underlying these malignancies." @default.
- W4380631645 created "2023-06-15" @default.
- W4380631645 creator A5017368777 @default.
- W4380631645 creator A5029383178 @default.
- W4380631645 creator A5082878069 @default.
- W4380631645 creator A5086304947 @default.
- W4380631645 creator A5089354223 @default.
- W4380631645 creator A5092167184 @default.
- W4380631645 creator A5092167185 @default.
- W4380631645 date "2023-06-13" @default.
- W4380631645 modified "2023-10-18" @default.
- W4380631645 title "Data mining identifies novel RNA-binding proteins involved in colon and rectal carcinomas" @default.
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