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• W4380677204 abstract "Introduction: Crohn's disease is a systemic inflammatory disease with high levels of cytokines that can lead to endothelial damage and atherosclerotic disease. We sought to evaluate the association between Crohn’s disease and mortality in patients hospitalized with Non-ST-Segment Elevation Myocardial Infarction (NSTEMI). Methods: Patients hospitalized for NSTEMI with and without Crohn’s disease between 2016 and 2018 were identified from the National Inpatient Sample. The primary outcome was all-cause mortality. The secondary outcomes were cardiac arrest, cardiogenic shock, acute respiratory failure, acute kidney injury, length of stay, and patient charge. A multivariable logistic regression analysis was used to adjust for in-hospital complications. A p-value of <0.05 was considered significant. Results: A total of 1,398,309 hospitalized patients with NSTEMI were identified. Of those, 3,356 patients (0.24%) were found to have Crohn's disease. Overall, the mean age was similar (66.4 years vs 68.1 years) among Crohn’s vs non-Crohn's patients. Crohn’s patients had less male (54.4% vs 59.8%) and more Caucasians (84.4% vs 72.5%). The primary outcome did not di!er significantly between the two groups; the rate of mortality was 2.2% in Crohn’s patients and 3.4% patients without Crohn’s disease in hospitalized patients with NSTEMI (Adjusted odds ratio, 0.67; 95% confidence interval, 0.34 to 1.30; p = 0.236). There was no statistical difference between the two groups regarding cardiac arrest, cardiogenic shock, acute respiratory failure, acute kidney injury, length of stay, and patient charge. Conclusions: Patients with Crohn’s disease in the setting of NSTEMI did not have a di!erence in mortality or other clinical outcomes when compared with patients without Crohn’s disease. As with most observational studies, causality may not be confirmed due to potential residual confounding." @default.
• W4380677204 created "2023-06-15" @default.
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• W4380677204 date "2022-11-08" @default.
• W4380677204 modified "2023-10-18" @default.
• W4380677204 title "Abstract 10201: Impact of Crohn’s Disease on Mortality and Outcomes in Hospitalized Patients Presenting With Non- St-segment Elevation Myocardial Infarction" @default.
• W4380677204 doi "https://doi.org/10.1161/circ.146.suppl_1.10201" @default.
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