FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380680274> ?p ?o ?g. }

• W4380680274 endingPage "739793" @default.
• W4380680274 startingPage "739793" @default.
• W4380680274 abstract "Vascular endothelial growth factor B (VEGFB), unlike other members of the VEGF family such as VEGFA, shows only limited potential in angiogenesis in mammals, but is involved in lipid metabolism, especially in transporting dietary lipids present in circulation through the vascular endothelium to peripheral tissues. However, the role of Vegfb in invertebrates such as decapod crustaceans with an open circulatory system is still poorly understood. Here, cDNA of a vegfb-like gene was cloned and characterized for the first time from a decapod crustacean, mud crab Scylla paramamosain. The mud crab vegfb-like gene encoded a polypeptide of 386 amino acids that possessed all the typical features of the Vegf family, and shared high homology with other crustacean Vegf orthologs. Relative expression levels of the vegfb-like gene were higher in metabolically active tissues such as gill, heart and muscle, and increased in ovary of female crabs as ovary matured. Knockdown of the vegfb-like gene in vivo reduced the contents of triglyceride in hemolymph and hepatopancreas, as well as total lipid in hepatopancreas. In addition, knockdown of the vegfb-like gene increased tissue expression levels of genes related to fatty acid transportation, allocation and hydrolysis, such as long-chain acyl-CoA synthetase 3/4 (acsl3/4), fatty acid transport protein 1 (fatp1), and hormone-sensitive lipase (hsl), and decreased the expression levels of the genes related to fatty acid synthesis like acetyl-CoA carboxylase (acc). These results in mud crab suggest that Vegfb might play important roles in regulating fatty acid absorption, utilization and allocation in crustaceans." @default.
• W4380680274 created "2023-06-15" @default.
• W4380680274 creator A5010552559 @default.
• W4380680274 creator A5030776837 @default.
• W4380680274 creator A5034531468 @default.
• W4380680274 creator A5035388221 @default.
• W4380680274 creator A5049533744 @default.
• W4380680274 creator A5055137150 @default.
• W4380680274 creator A5057884102 @default.
• W4380680274 creator A5058752026 @default.
• W4380680274 creator A5062725575 @default.
• W4380680274 creator A5064611844 @default.
• W4380680274 creator A5069246489 @default.
• W4380680274 creator A5075392356 @default.
• W4380680274 creator A5084905573 @default.
• W4380680274 date "2023-10-01" @default.
• W4380680274 modified "2023-09-23" @default.
• W4380680274 title "Identification of a novel crustacean vascular endothelial growth factor b-like in the mud crab Scylla paramamosain, and examination of its role in lipid accumulation" @default.
• W4380680274 cites W1967009186 @default.
• W4380680274 cites W1977049540 @default.
• W4380680274 cites W1980867773 @default.
• W4380680274 cites W1993531787 @default.
• W4380680274 cites W1994472120 @default.
• W4380680274 cites W1995206997 @default.
• W4380680274 cites W2001538457 @default.
• W4380680274 cites W2004523281 @default.
• W4380680274 cites W2023396160 @default.
• W4380680274 cites W2025604848 @default.
• W4380680274 cites W2026644276 @default.
• W4380680274 cites W2029193079 @default.
• W4380680274 cites W2035107695 @default.
• W4380680274 cites W2036496650 @default.
• W4380680274 cites W2037028884 @default.
• W4380680274 cites W2037730388 @default.
• W4380680274 cites W2053221827 @default.
• W4380680274 cites W2053429350 @default.
• W4380680274 cites W2063027760 @default.
• W4380680274 cites W2072307555 @default.
• W4380680274 cites W2076374640 @default.
• W4380680274 cites W2078740418 @default.
• W4380680274 cites W2078905435 @default.
• W4380680274 cites W2086453930 @default.
• W4380680274 cites W2106098568 @default.
• W4380680274 cites W2111453579 @default.
• W4380680274 cites W2113190364 @default.
• W4380680274 cites W2114465850 @default.
• W4380680274 cites W2125670691 @default.
• W4380680274 cites W2152311269 @default.
• W4380680274 cites W2152911705 @default.
• W4380680274 cites W2153336237 @default.
• W4380680274 cites W2161715037 @default.
• W4380680274 cites W2164100413 @default.
• W4380680274 cites W2168812832 @default.
• W4380680274 cites W2257363456 @default.
• W4380680274 cites W2291683698 @default.
• W4380680274 cites W2342209444 @default.
• W4380680274 cites W2403007304 @default.
• W4380680274 cites W2486397717 @default.
• W4380680274 cites W2515225743 @default.
• W4380680274 cites W2523029527 @default.
• W4380680274 cites W2586116826 @default.
• W4380680274 cites W2587180704 @default.
• W4380680274 cites W2745132840 @default.
• W4380680274 cites W2781867864 @default.
• W4380680274 cites W2795443756 @default.
• W4380680274 cites W2895998152 @default.
• W4380680274 cites W2949319857 @default.
• W4380680274 cites W2969838506 @default.
• W4380680274 cites W2981244931 @default.
• W4380680274 cites W2998833723 @default.
• W4380680274 cites W3026085056 @default.
• W4380680274 cites W3040774192 @default.
• W4380680274 cites W3087275543 @default.
• W4380680274 cites W3114701057 @default.
• W4380680274 cites W3123219438 @default.
• W4380680274 cites W3145699426 @default.
• W4380680274 cites W3200048091 @default.
• W4380680274 cites W4288684323 @default.
• W4380680274 cites W4289843479 @default.
• W4380680274 doi "https://doi.org/10.1016/j.aquaculture.2023.739793" @default.
• W4380680274 hasPublicationYear "2023" @default.
• W4380680274 type Work @default.
• W4380680274 citedByCount "0" @default.
• W4380680274 crossrefType "journal-article" @default.
• W4380680274 hasAuthorship W4380680274A5010552559 @default.
• W4380680274 hasAuthorship W4380680274A5030776837 @default.
• W4380680274 hasAuthorship W4380680274A5034531468 @default.
• W4380680274 hasAuthorship W4380680274A5035388221 @default.
• W4380680274 hasAuthorship W4380680274A5049533744 @default.
• W4380680274 hasAuthorship W4380680274A5055137150 @default.
• W4380680274 hasAuthorship W4380680274A5057884102 @default.
• W4380680274 hasAuthorship W4380680274A5058752026 @default.
• W4380680274 hasAuthorship W4380680274A5062725575 @default.
• W4380680274 hasAuthorship W4380680274A5064611844 @default.
• W4380680274 hasAuthorship W4380680274A5069246489 @default.
• W4380680274 hasAuthorship W4380680274A5075392356 @default.
• W4380680274 hasAuthorship W4380680274A5084905573 @default.
• W4380680274 hasConcept C100068826 @default.

• next