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- W4380680602 abstract "Background Microbiota unbalance has been proven to affect chronic kidney disease (CKD) patients and, noteworthy, microbiota composition and activity are implicated in CKD worsening. The progression of kidney failure implies an exceeding accumulation of waste compounds deriving from the nitrogenous metabolism in the intestinal milieu. Therefore, in the presence of an altered intestinal permeability, gut-derived uremic toxins, i.e., indoxyl sulfate (IS) and p-cresyl sulfate (PCS), can accumulate in the blood. Methods In a scenario facing the nutritional management as adjuvant therapy, the present study assessed the effectiveness of an innovative synbiotics for its ability to modulate the patient gut microbiota and metabolome by setting a randomized, single-blind, placebo-controlled, pilot trial accounting for IIIb-IV stage CKD patients and healthy controls. Metataxonomic fecal microbiota and fecal volatilome were analyzed at the run-in, after 2 months of treatment, and after 1 month of wash out. Results Significant changes in microbiota profile, as well as an increase of the saccharolytic metabolism, in feces were found for those CKD patients that were allocated in the synbiotics arm. Conclusions Noteworthy, the here analyzed data emphasized a selective efficacy of the present synbiotics on a stage IIIb-IV CKD patients. Nonetheless, a further validation of this trial accounting for an increased patient number should be considered. Clinical trial registration https://clinicaltrials.gov/ , identifier NCT03815786." @default.
- W4380680602 created "2023-06-15" @default.
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- W4380680602 date "2023-06-15" @default.
- W4380680602 modified "2023-09-26" @default.
- W4380680602 title "In vivo evaluation of an innovative synbiotics on stage IIIb-IV chronic kidney disease patients" @default.
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- W4380680602 cites W1989268575 @default.
- W4380680602 cites W1990590570 @default.
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- W4380680602 cites W2011828044 @default.
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- W4380680602 doi "https://doi.org/10.3389/fnut.2023.1215836" @default.
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