Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380681822> ?p ?o ?g. }
- W4380681822 abstract "Substance Use Disorder (SUD) involves emotional, cognitive, and motivational dysfunction. Long-lasting molecular and structural changes in brain regions functionally and anatomically linked to the cerebellum, such as the prefrontal cortex, amygdala, hippocampus, basal ganglia, and ventral tegmental area, are characteristic of SUD. Direct and indirect reciprocal connectivity between the cerebellum and these brain regions can explain cerebellar roles in Pavlovian and reinforcement learning, fear memory, and executive functions. It is increasingly clear that the cerebellum modulates brain functions altered in SUD and other neuropsychiatric disorders that exhibit comorbidity with SUD. In the present manuscript, we review and discuss this evidence and present new research exploring the role of the cerebellum in cocaine-induced conditioned memory using chemogenetic tools (designer receptor exclusively activated by designer drug, DREADDs). Our preliminary data showed that inactivation of a region that includes the interposed and lateral deep cerebellar nuclei reduces the facilitating effect of a posterior vermis lesion on cocaine-induced preference conditioning. These findings support our previous research and suggest that posterior vermis damage may increase drug impact on the addiction circuitry by regulating activity in the DCN. However, they raise further questions that will also be discussed." @default.
- W4380681822 created "2023-06-15" @default.
- W4380681822 creator A5011910797 @default.
- W4380681822 creator A5018119909 @default.
- W4380681822 creator A5038362373 @default.
- W4380681822 creator A5057754037 @default.
- W4380681822 creator A5059593624 @default.
- W4380681822 creator A5087927787 @default.
- W4380681822 date "2023-06-14" @default.
- W4380681822 modified "2023-10-17" @default.
- W4380681822 title "Putting forward a model for the role of the cerebellum in cocaine-induced pavlovian memory" @default.
- W4380681822 cites W1498104517 @default.
- W4380681822 cites W1537830243 @default.
- W4380681822 cites W1549658809 @default.
- W4380681822 cites W15594535 @default.
- W4380681822 cites W1570841376 @default.
- W4380681822 cites W1870304014 @default.
- W4380681822 cites W1913760354 @default.
- W4380681822 cites W1920312125 @default.
- W4380681822 cites W1962727914 @default.
- W4380681822 cites W1968290426 @default.
- W4380681822 cites W1977644171 @default.
- W4380681822 cites W1985220647 @default.
- W4380681822 cites W1996262090 @default.
- W4380681822 cites W1997128521 @default.
- W4380681822 cites W2007046305 @default.
- W4380681822 cites W2010824161 @default.
- W4380681822 cites W2012198383 @default.
- W4380681822 cites W2013940388 @default.
- W4380681822 cites W2019228762 @default.
- W4380681822 cites W2022080498 @default.
- W4380681822 cites W2022235619 @default.
- W4380681822 cites W2027404202 @default.
- W4380681822 cites W2028338391 @default.
- W4380681822 cites W2034354169 @default.
- W4380681822 cites W2038566061 @default.
- W4380681822 cites W2047530720 @default.
- W4380681822 cites W2049952807 @default.
- W4380681822 cites W2054749214 @default.
- W4380681822 cites W2059192453 @default.
- W4380681822 cites W2059466731 @default.
- W4380681822 cites W2059869176 @default.
- W4380681822 cites W2061043823 @default.
- W4380681822 cites W2061994341 @default.
- W4380681822 cites W2069691999 @default.
- W4380681822 cites W2078530990 @default.
- W4380681822 cites W2087281728 @default.
- W4380681822 cites W2089089729 @default.
- W4380681822 cites W2097139733 @default.
- W4380681822 cites W2104284834 @default.
- W4380681822 cites W2120976644 @default.
- W4380681822 cites W2124231060 @default.
- W4380681822 cites W2125814499 @default.
- W4380681822 cites W2127679982 @default.
- W4380681822 cites W2132327443 @default.
- W4380681822 cites W2134172496 @default.
- W4380681822 cites W2138204170 @default.
- W4380681822 cites W2142461473 @default.
- W4380681822 cites W2150276468 @default.
- W4380681822 cites W2153998371 @default.
- W4380681822 cites W2158900973 @default.
- W4380681822 cites W2167279371 @default.
- W4380681822 cites W2171976136 @default.
- W4380681822 cites W2173594263 @default.
- W4380681822 cites W2280915780 @default.
- W4380681822 cites W2331213745 @default.
- W4380681822 cites W2343606810 @default.
- W4380681822 cites W2406761013 @default.
- W4380681822 cites W2420634624 @default.
- W4380681822 cites W2553239728 @default.
- W4380681822 cites W2587419370 @default.
- W4380681822 cites W2589380535 @default.
- W4380681822 cites W2595087345 @default.
- W4380681822 cites W2736086129 @default.
- W4380681822 cites W2787084465 @default.
- W4380681822 cites W2798091161 @default.
- W4380681822 cites W2803693945 @default.
- W4380681822 cites W2892244192 @default.
- W4380681822 cites W2895536619 @default.
- W4380681822 cites W2898022217 @default.
- W4380681822 cites W2908580509 @default.
- W4380681822 cites W2908730501 @default.
- W4380681822 cites W2912962815 @default.
- W4380681822 cites W2913822739 @default.
- W4380681822 cites W2929898295 @default.
- W4380681822 cites W2944480430 @default.
- W4380681822 cites W2948144317 @default.
- W4380681822 cites W2949240801 @default.
- W4380681822 cites W2955918581 @default.
- W4380681822 cites W2972144997 @default.
- W4380681822 cites W2972815701 @default.
- W4380681822 cites W2993605026 @default.
- W4380681822 cites W2998688799 @default.
- W4380681822 cites W3012511554 @default.
- W4380681822 cites W3034488128 @default.
- W4380681822 cites W3041250095 @default.
- W4380681822 cites W3088079475 @default.
- W4380681822 cites W3090105988 @default.
- W4380681822 cites W3092754847 @default.
- W4380681822 cites W3094084645 @default.