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- W4380682426 abstract "Hepatocellular carcinoma (HCC) represents a worryingly increasing cause of malignancy-related mortality, while Metabolic Associated Fatty Liver Disease (MAFLD) is going to become its most common cause in the next decade. Understanding the complex underlying pathophysiology of MAFLD-related HCC can provide opportunities for successful targeted therapies. Of particular interest in this sequela of hepatopathology is cellular senescence, a complex process characterised by cellular cycle arrest initiated by a variety of endogenous and exogenous cell stressors. A key biological process in establishing and maintaining senescence is oxidative stress, which is present in multiple cellular compartments of steatotic hepatocytes. Oxidative stress-induced cellular senescence can change hepatocyte function and metabolism, and alter, in a paracrine manner, the hepatic microenvironment, enabling disease progression from simple steatosis to inflammation and fibrosis, as well as HCC. The duration of senescence and the cell types it affects can tilt the scale from a tumour-protective self-restricting phenotype to the creator of an oncogenic hepatic milieu. A deeper understanding of the mechanism of the disease can guide the selection of the most appropriate senotherapeutic agent, as well as the optimal timing and cell type targeting for effectively combating HCC." @default.
- W4380682426 created "2023-06-15" @default.
- W4380682426 creator A5017642140 @default.
- W4380682426 creator A5034989963 @default.
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- W4380682426 creator A5081956488 @default.
- W4380682426 date "2023-06-14" @default.
- W4380682426 modified "2023-09-27" @default.
- W4380682426 title "The Role of Oxidative Stress and Cellular Senescence in the Pathogenesis of Metabolic Associated Fatty Liver Disease and Related Hepatocellular Carcinoma" @default.
- W4380682426 cites W1553367038 @default.
- W4380682426 cites W1614231230 @default.
- W4380682426 cites W1659141691 @default.
- W4380682426 cites W1952814383 @default.
- W4380682426 cites W1965980904 @default.
- W4380682426 cites W1970891016 @default.
- W4380682426 cites W1973185531 @default.
- W4380682426 cites W1978459962 @default.
- W4380682426 cites W1995542159 @default.
- W4380682426 cites W2004273407 @default.
- W4380682426 cites W2005119615 @default.
- W4380682426 cites W2013287222 @default.
- W4380682426 cites W2013513457 @default.
- W4380682426 cites W2019486401 @default.
- W4380682426 cites W2025751643 @default.
- W4380682426 cites W203746906 @default.
- W4380682426 cites W2048613643 @default.
- W4380682426 cites W2061182191 @default.
- W4380682426 cites W2068337326 @default.
- W4380682426 cites W2079241145 @default.
- W4380682426 cites W2085128107 @default.
- W4380682426 cites W2108887402 @default.
- W4380682426 cites W2115852450 @default.
- W4380682426 cites W2116672880 @default.
- W4380682426 cites W2121591739 @default.
- W4380682426 cites W2132224453 @default.
- W4380682426 cites W2132406938 @default.
- W4380682426 cites W2140930678 @default.
- W4380682426 cites W2154903097 @default.
- W4380682426 cites W2169986172 @default.
- W4380682426 cites W2191745121 @default.
- W4380682426 cites W2193792657 @default.
- W4380682426 cites W2253667517 @default.
- W4380682426 cites W2291173445 @default.
- W4380682426 cites W2315512556 @default.
- W4380682426 cites W2341898654 @default.
- W4380682426 cites W2418260023 @default.
- W4380682426 cites W2468517437 @default.
- W4380682426 cites W2474566658 @default.
- W4380682426 cites W2504155943 @default.
- W4380682426 cites W2509652077 @default.
- W4380682426 cites W2517870227 @default.
- W4380682426 cites W2527472313 @default.
- W4380682426 cites W2530507445 @default.
- W4380682426 cites W2530995434 @default.
- W4380682426 cites W2535350081 @default.
- W4380682426 cites W2549447033 @default.
- W4380682426 cites W2561612682 @default.
- W4380682426 cites W2596611512 @default.
- W4380682426 cites W2611610643 @default.
- W4380682426 cites W2613180696 @default.
- W4380682426 cites W2624997514 @default.
- W4380682426 cites W2726866747 @default.
- W4380682426 cites W2742007963 @default.
- W4380682426 cites W2762087180 @default.
- W4380682426 cites W2769242138 @default.
- W4380682426 cites W2770342510 @default.
- W4380682426 cites W2775763986 @default.
- W4380682426 cites W2802276006 @default.
- W4380682426 cites W2911639560 @default.
- W4380682426 cites W2942695470 @default.
- W4380682426 cites W2947461116 @default.
- W4380682426 cites W2950304894 @default.
- W4380682426 cites W2950768628 @default.
- W4380682426 cites W2969617477 @default.
- W4380682426 cites W2969802526 @default.
- W4380682426 cites W2972310443 @default.
- W4380682426 cites W2979641493 @default.
- W4380682426 cites W2988310131 @default.
- W4380682426 cites W3013352992 @default.
- W4380682426 cites W3013842488 @default.
- W4380682426 cites W3015579983 @default.
- W4380682426 cites W3031976336 @default.
- W4380682426 cites W3034691659 @default.
- W4380682426 cites W3047289293 @default.
- W4380682426 cites W3048272802 @default.
- W4380682426 cites W3087420178 @default.
- W4380682426 cites W3094308685 @default.
- W4380682426 cites W3107777878 @default.
- W4380682426 cites W3107926998 @default.
- W4380682426 cites W3124800569 @default.
- W4380682426 cites W3126209233 @default.
- W4380682426 cites W3126531350 @default.
- W4380682426 cites W3128646645 @default.
- W4380682426 cites W3135028306 @default.