Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380685156> ?p ?o ?g. }
- W4380685156 endingPage "3056" @default.
- W4380685156 startingPage "3042" @default.
- W4380685156 abstract "Forkhead box protein O3 (FOXO3) has good inhibition ability toward fibroblast activation and extracellular matrix, especially for the treatment of idiopathic pulmonary fibrosis. How FOXO3 regulates pulmonary fibrosis remains unclear. In this study, we reported that FOXO3 had binding sequences with F-spondin 1 (SPON1) promoter, which can activate its transcription and selectively promote the expression of SPON1 circRNA (circSPON1) but not mRNA expression. We further demonstrated that circSPON1 was involved in the extracellular matrix deposition of HFL1. In the cytoplasm, circSPON1 directly interacted with TGF-β1-induced Smad3 and inhibited the activation of fibroblasts by inhibiting nuclear translocation. Moreover, circSPON1 bound to miR-942-5p and miR-520f-3p that interfered with Smad7 mRNA and promoted Smad7 expression. This study revealed the mechanism of FOXO3-regulated circSPON1 in the development of pulmonary fibrosis. Potential therapeutic targets and new insights into the diagnosis and treatment of idiopathic pulmonary fibrosis based on circRNA were also provided." @default.
- W4380685156 created "2023-06-15" @default.
- W4380685156 creator A5012188919 @default.
- W4380685156 creator A5013913588 @default.
- W4380685156 creator A5031048239 @default.
- W4380685156 creator A5041659230 @default.
- W4380685156 creator A5058481549 @default.
- W4380685156 creator A5060189952 @default.
- W4380685156 creator A5067703584 @default.
- W4380685156 creator A5071809368 @default.
- W4380685156 creator A5075690063 @default.
- W4380685156 creator A5076055846 @default.
- W4380685156 creator A5084748257 @default.
- W4380685156 creator A5085610505 @default.
- W4380685156 creator A5087148923 @default.
- W4380685156 creator A5087153998 @default.
- W4380685156 creator A5087936965 @default.
- W4380685156 date "2023-01-01" @default.
- W4380685156 modified "2023-10-14" @default.
- W4380685156 title "FOXO3 regulates Smad3 and Smad7 through SPON1 circular RNA to inhibit idiopathic pulmonary fibrosis" @default.
- W4380685156 cites W1968008181 @default.
- W4380685156 cites W1971305923 @default.
- W4380685156 cites W1979505297 @default.
- W4380685156 cites W1989622233 @default.
- W4380685156 cites W2003254802 @default.
- W4380685156 cites W2005331723 @default.
- W4380685156 cites W2006318229 @default.
- W4380685156 cites W2018809578 @default.
- W4380685156 cites W2031593782 @default.
- W4380685156 cites W2034779933 @default.
- W4380685156 cites W2054580894 @default.
- W4380685156 cites W2054891772 @default.
- W4380685156 cites W2058835062 @default.
- W4380685156 cites W2059109598 @default.
- W4380685156 cites W2083969171 @default.
- W4380685156 cites W2089806143 @default.
- W4380685156 cites W2149846303 @default.
- W4380685156 cites W2155840627 @default.
- W4380685156 cites W2187818572 @default.
- W4380685156 cites W2209661158 @default.
- W4380685156 cites W2473991067 @default.
- W4380685156 cites W2764294957 @default.
- W4380685156 cites W2765658585 @default.
- W4380685156 cites W2773754711 @default.
- W4380685156 cites W2790507111 @default.
- W4380685156 cites W2888828322 @default.
- W4380685156 cites W2889197569 @default.
- W4380685156 cites W2890037152 @default.
- W4380685156 cites W2893792076 @default.
- W4380685156 cites W2901477547 @default.
- W4380685156 cites W2950826375 @default.
- W4380685156 cites W2967043226 @default.
- W4380685156 cites W2978686205 @default.
- W4380685156 cites W3004292322 @default.
- W4380685156 cites W3006998660 @default.
- W4380685156 cites W3014947672 @default.
- W4380685156 cites W3020855961 @default.
- W4380685156 cites W3033500181 @default.
- W4380685156 cites W3037253620 @default.
- W4380685156 cites W3044734159 @default.
- W4380685156 cites W3105048370 @default.
- W4380685156 cites W3125775316 @default.
- W4380685156 cites W3167722610 @default.
- W4380685156 doi "https://doi.org/10.7150/ijbs.80140" @default.
- W4380685156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37416778" @default.
- W4380685156 hasPublicationYear "2023" @default.
- W4380685156 type Work @default.
- W4380685156 citedByCount "0" @default.
- W4380685156 crossrefType "journal-article" @default.
- W4380685156 hasAuthorship W4380685156A5012188919 @default.
- W4380685156 hasAuthorship W4380685156A5013913588 @default.
- W4380685156 hasAuthorship W4380685156A5031048239 @default.
- W4380685156 hasAuthorship W4380685156A5041659230 @default.
- W4380685156 hasAuthorship W4380685156A5058481549 @default.
- W4380685156 hasAuthorship W4380685156A5060189952 @default.
- W4380685156 hasAuthorship W4380685156A5067703584 @default.
- W4380685156 hasAuthorship W4380685156A5071809368 @default.
- W4380685156 hasAuthorship W4380685156A5075690063 @default.
- W4380685156 hasAuthorship W4380685156A5076055846 @default.
- W4380685156 hasAuthorship W4380685156A5084748257 @default.
- W4380685156 hasAuthorship W4380685156A5085610505 @default.
- W4380685156 hasAuthorship W4380685156A5087148923 @default.
- W4380685156 hasAuthorship W4380685156A5087153998 @default.
- W4380685156 hasAuthorship W4380685156A5087936965 @default.
- W4380685156 hasBestOaLocation W43806851561 @default.
- W4380685156 hasConcept C104317684 @default.
- W4380685156 hasConcept C105580179 @default.
- W4380685156 hasConcept C118131993 @default.
- W4380685156 hasConcept C126322002 @default.
- W4380685156 hasConcept C142724271 @default.
- W4380685156 hasConcept C168003608 @default.
- W4380685156 hasConcept C185592680 @default.
- W4380685156 hasConcept C189165786 @default.
- W4380685156 hasConcept C2777714996 @default.
- W4380685156 hasConcept C2778341716 @default.
- W4380685156 hasConcept C2780381497 @default.
- W4380685156 hasConcept C2780559512 @default.
- W4380685156 hasConcept C2781244666 @default.