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• W4380686637 abstract "Methotrexate (MTX) is a readily accessible drug, first used in 1948 and employed for a wide variety of indications since then. However, despite widespread off-label use, FDA labeling does not include approved indications for the use of MTX for many inflammatory skin diseases in pediatric patients, including morphea, psoriasis, atopic dermatitis, and alopecia areata, among others. Without published treatment guidelines, some clinicians may be hesitant to use MTX off-label, or uncomfortable prescribing MTX in this population. To address this unmet need, an expert consensus committee was convened to develop evidence- and consensus-based guidelines for use of MTX to treat pediatric inflammatory skin disease. Clinicians with experience and expertise in clinical research, drug development, and treating inflammatory skin disease in pediatric patients with MTX were recruited. Five committees were created based on major topic areas: (1) indications and contraindications, (2) dosing, (3) interactions with immunizations and medications, (4) adverse effects (potential for and management of), and (5) monitoring needs. Pertinent questions were generated and addressed by the relevant committee. The entire group participated in a modified Delphi process to establish agreement on recommendations for each question. The committee developed 46 evidence- and consensus-based recommendations, each with >70% agreement among members, across all five topics. These are presented in tables and text, along with a discussion of supporting literature, and level of evidence. These evidence- and consensus-based recommendations will support safe and effective use of MTX for the underserved population of pediatric patients who may benefit from this valuable, time-honored medication." @default.
• W4380686637 created "2023-06-15" @default.
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• W4380686637 date "2023-06-14" @default.
• W4380686637 modified "2023-09-29" @default.
• W4380686637 title "Methotrexate for inflammatory skin disease in pediatric patients: Consensus treatment guidelines" @default.
• W4380686637 cites W1482778265 @default.
• W4380686637 cites W1596208797 @default.
• W4380686637 cites W1639283502 @default.
• W4380686637 cites W189068515 @default.
• W4380686637 cites W1893900021 @default.
• W4380686637 cites W1967129434 @default.
• W4380686637 cites W1968663861 @default.
• W4380686637 cites W1969585600 @default.
• W4380686637 cites W1969991375 @default.
• W4380686637 cites W1976717494 @default.
• W4380686637 cites W1977487899 @default.
• W4380686637 cites W1986006830 @default.
• W4380686637 cites W1987367856 @default.
• W4380686637 cites W1997709264 @default.
• W4380686637 cites W2000654246 @default.
• W4380686637 cites W2000967575 @default.
• W4380686637 cites W2002801452 @default.
• W4380686637 cites W2011427506 @default.
• W4380686637 cites W2013906667 @default.
• W4380686637 cites W2014233261 @default.
• W4380686637 cites W2016284731 @default.
• W4380686637 cites W2016759483 @default.
• W4380686637 cites W2017839708 @default.
• W4380686637 cites W2020944857 @default.
• W4380686637 cites W2024476792 @default.
• W4380686637 cites W2030431646 @default.
• W4380686637 cites W2032966734 @default.
• W4380686637 cites W2038348762 @default.
• W4380686637 cites W2040764711 @default.
• W4380686637 cites W2043306063 @default.
• W4380686637 cites W2050075893 @default.
• W4380686637 cites W2057161282 @default.
• W4380686637 cites W2060496388 @default.
• W4380686637 cites W2062131210 @default.
• W4380686637 cites W2063397850 @default.
• W4380686637 cites W2064119537 @default.
• W4380686637 cites W2076314306 @default.
• W4380686637 cites W2079100622 @default.
• W4380686637 cites W2080318211 @default.
• W4380686637 cites W2083614315 @default.
• W4380686637 cites W2088395024 @default.
• W4380686637 cites W2099981435 @default.
• W4380686637 cites W2102919506 @default.
• W4380686637 cites W2104729127 @default.
• W4380686637 cites W2107628081 @default.
• W4380686637 cites W2112133313 @default.
• W4380686637 cites W2112187168 @default.
• W4380686637 cites W2114323429 @default.
• W4380686637 cites W2118270386 @default.
• W4380686637 cites W2125858194 @default.
• W4380686637 cites W2126213746 @default.
• W4380686637 cites W2133596428 @default.
• W4380686637 cites W2135974703 @default.
• W4380686637 cites W2138814539 @default.
• W4380686637 cites W2142725512 @default.
• W4380686637 cites W2147274916 @default.
• W4380686637 cites W2150247495 @default.
• W4380686637 cites W2153518365 @default.
• W4380686637 cites W2156498191 @default.
• W4380686637 cites W2162065782 @default.
• W4380686637 cites W2166059882 @default.
• W4380686637 cites W2169983987 @default.
• W4380686637 cites W2293144235 @default.
• W4380686637 cites W2318635543 @default.
• W4380686637 cites W2342174771 @default.
• W4380686637 cites W2411305690 @default.
• W4380686637 cites W2439413962 @default.
• W4380686637 cites W2499585047 @default.

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