FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380730892> ?p ?o ?g. }

• W4380730892 endingPage "10865" @default.
• W4380730892 startingPage "10851" @default.
• W4380730892 abstract "The serine protease inhibitor clade E member 1 (SERPINE1) has been studied as a potential biomarker in a variety of cancers, but poorly studied in gastric cancer (GC). The purpose of this study was to explore the prognostic value of SERPINE1 in GC and primarily analyze its functions.We analyzed the the prognostic value of SERPINE1 and studied the relationship with clinicopathologic biomarkers in gastric cancer. The expression of SERPINE1 was analyzed by GEO and TCGA databases. Moreover, we validated the results by immunohistochemistry. Next, the correlation analysis between SERPINE1 and the cuproptosis-related genes was analyzed by the Spearman method. CIBERSORT and TIMER algorithms were used to analyze the correlation of SERPINE1 with immune infiltration. Furthermore, GO and KEGG gene enrichment analyses were used to study the functions and pathways that SERPINE1 might be involved in. Then, drug sensitivity analysis was performed using CellMiner database. Finally, a cuproptosis-immune-related prognostic model was constructed using genes related to immune and cuproptosis, and verified against external datasets.SERPINE1 was up-regulated in gastric cancer tissues, which tends toward poor prognosis. Using immunohistochemistry experiment, the expression and prognostic value of SERPINE1 were verified. Then, we found that SERPINE1 was negatively correlated with cuproptosis-related genes FDX1, LIAS, LIPT1, and PDHA1. On the contrary, SERPINE1 was positively correlated with APOE. This indicates the effect of SERPINE1 on the cuproptosis process. Furthermore, by conducting immune-related analyses, it was revealed that SERPINE1 may promote the inhibitory immune microenvironment. The infiltration level of resting NK cells, neutrophils, activated mast cells, and macrophages M2 was positively correlated with SERPINE1. However, B cell memory and plasma cells were negatively correlated with SERPINE1. Functional analysis showed that SERPINE1 was closely related to angiogenesis, apoptosis, and ECM degradation. The KEGG pathway analysis showed that SERPINE1 may be associated with P53, Pi3k/Akt, TGF-β, and other signaling pathways. Drug sensitivity analysis showed that SERPINE1 could be also seen as a potential treatment target. The risk model based on SERPINE1 co-expression genes could better predict the survival of GC patients than SERPINE1 alone. We also verified the prognostic value of the risk score by GEO external datasets.SERPINE1 is highly expressed in gastric cancer and related to poor prognosis. SERPINE1 may regulate cuproptosis and the immune microenvironment by a series of pathways. Therefore, SERPINE1 as a prognostic biomarker and potential therapeutic target deserves further study." @default.
• W4380730892 created "2023-06-16" @default.
• W4380730892 creator A5016940257 @default.
• W4380730892 creator A5042862973 @default.
• W4380730892 creator A5056931786 @default.
• W4380730892 creator A5066999858 @default.
• W4380730892 creator A5077250298 @default.
• W4380730892 date "2023-06-15" @default.
• W4380730892 modified "2023-10-01" @default.
• W4380730892 title "Cuproptosis-related gene SERPINE1 is a prognostic biomarker and correlated with immune infiltrates in gastric cancer" @default.
• W4380730892 cites W1261060707 @default.
• W4380730892 cites W2074672488 @default.
• W4380730892 cites W2093608608 @default.
• W4380730892 cites W2122686914 @default.
• W4380730892 cites W2124439755 @default.
• W4380730892 cites W2134786458 @default.
• W4380730892 cites W2152049148 @default.
• W4380730892 cites W2470401678 @default.
• W4380730892 cites W2599595460 @default.
• W4380730892 cites W2770358284 @default.
• W4380730892 cites W2911581693 @default.
• W4380730892 cites W2919586790 @default.
• W4380730892 cites W2937823726 @default.
• W4380730892 cites W2949473906 @default.
• W4380730892 cites W2986671954 @default.
• W4380730892 cites W3045095099 @default.
• W4380730892 cites W3084435648 @default.
• W4380730892 cites W3117399032 @default.
• W4380730892 cites W3118258741 @default.
• W4380730892 cites W3128646645 @default.
• W4380730892 cites W3164654239 @default.
• W4380730892 cites W3166925522 @default.
• W4380730892 cites W3176202945 @default.
• W4380730892 cites W3186222380 @default.
• W4380730892 cites W3194040044 @default.
• W4380730892 cites W4205257525 @default.
• W4380730892 cites W4210813406 @default.
• W4380730892 cites W4214862149 @default.
• W4380730892 cites W4283659295 @default.
• W4380730892 cites W4285012525 @default.
• W4380730892 cites W4296053198 @default.
• W4380730892 cites W4297964967 @default.
• W4380730892 cites W4306391391 @default.
• W4380730892 doi "https://doi.org/10.1007/s00432-023-04900-1" @default.
• W4380730892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37318594" @default.
• W4380730892 hasPublicationYear "2023" @default.
• W4380730892 type Work @default.
• W4380730892 citedByCount "2" @default.
• W4380730892 countsByYear W43807308922023 @default.
• W4380730892 crossrefType "journal-article" @default.
• W4380730892 hasAuthorship W4380730892A5016940257 @default.
• W4380730892 hasAuthorship W4380730892A5042862973 @default.
• W4380730892 hasAuthorship W4380730892A5056931786 @default.
• W4380730892 hasAuthorship W4380730892A5066999858 @default.
• W4380730892 hasAuthorship W4380730892A5077250298 @default.
• W4380730892 hasBestOaLocation W43807308921 @default.
• W4380730892 hasConcept C121608353 @default.
• W4380730892 hasConcept C126322002 @default.
• W4380730892 hasConcept C143998085 @default.
• W4380730892 hasConcept C203014093 @default.
• W4380730892 hasConcept C204232928 @default.
• W4380730892 hasConcept C2781197716 @default.
• W4380730892 hasConcept C502942594 @default.
• W4380730892 hasConcept C54355233 @default.
• W4380730892 hasConcept C71924100 @default.
• W4380730892 hasConcept C86803240 @default.
• W4380730892 hasConcept C8891405 @default.
• W4380730892 hasConceptScore W4380730892C121608353 @default.
• W4380730892 hasConceptScore W4380730892C126322002 @default.
• W4380730892 hasConceptScore W4380730892C143998085 @default.
• W4380730892 hasConceptScore W4380730892C203014093 @default.
• W4380730892 hasConceptScore W4380730892C204232928 @default.
• W4380730892 hasConceptScore W4380730892C2781197716 @default.
• W4380730892 hasConceptScore W4380730892C502942594 @default.
• W4380730892 hasConceptScore W4380730892C54355233 @default.
• W4380730892 hasConceptScore W4380730892C71924100 @default.
• W4380730892 hasConceptScore W4380730892C86803240 @default.
• W4380730892 hasConceptScore W4380730892C8891405 @default.
• W4380730892 hasIssue "12" @default.
• W4380730892 hasLocation W43807308921 @default.
• W4380730892 hasLocation W43807308922 @default.
• W4380730892 hasOpenAccess W4380730892 @default.
• W4380730892 hasPrimaryLocation W43807308921 @default.
• W4380730892 hasRelatedWork W2056075233 @default.
• W4380730892 hasRelatedWork W2056385328 @default.
• W4380730892 hasRelatedWork W2064121576 @default.
• W4380730892 hasRelatedWork W2220102944 @default.
• W4380730892 hasRelatedWork W2392778271 @default.
• W4380730892 hasRelatedWork W2577548098 @default.
• W4380730892 hasRelatedWork W3031852375 @default.
• W4380730892 hasRelatedWork W3112940496 @default.
• W4380730892 hasRelatedWork W3187326853 @default.
• W4380730892 hasRelatedWork W4291367166 @default.
• W4380730892 hasVolume "149" @default.
• W4380730892 isParatext "false" @default.
• W4380730892 isRetracted "false" @default.
• W4380730892 workType "article" @default.