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- W4380730928 abstract "To discover novel laccase inhibitors as potential fungicides, twenty-six novel L-menthol hydrazide derivatives were designed and synthesized. In the in vitro antifungal assay, most of the target compounds displayed pronounced antifungal activity against Sclerotinia sclerotiorum, Fusarium graminearum, and Botryosphaeria dothidea. Especially, the EC50 of compounds 3 b and 3 q against B. dothidea was 0.465 and 0.622 mg/L, which was close to the positive compound fluxapyroxad (EC50=0.322 mg/L). Scanning electron microscopy (SEM) analysis showed that compound 3 b could significantly damage the mycelial morphology of B. dothidea. In vivo antifungal experiments on apple fruits showed that 3 b exhibited excellent protective and curative effects. Furthermore, in the in vitro laccase inhibition assay, 3 b showed outstanding inhibitory activity with the IC50 value of 2.08 μM, which is much stronger than positive control cysteine and PMDD-5Y. These results indicated that this class of L-menthol derivatives could be promising leads for the discovery of laccase-targeting fungicides." @default.
- W4380730928 created "2023-06-16" @default.
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- W4380730928 date "2023-06-28" @default.
- W4380730928 modified "2023-10-17" @default.
- W4380730928 title "Synthesis and Antifungal Activity of Novel L‐Menthol Hydrazide Derivatives as Potential Laccase Inhibitors" @default.
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- W4380730928 doi "https://doi.org/10.1002/cbdv.202300539" @default.
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