Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380738388> ?p ?o ?g. }
- W4380738388 abstract "Retinoic acid receptor (RAR) signaling is essential for mammalian kidney development, but in the adult kidney is restricted to occasional collecting duct epithelial cells. We now show there is widespread reactivation of RAR signaling in proximal tubular epithelial cells (PTECs) in human sepsis-associated acute kidney injury (AKI), and in mouse models of AKI. Genetic inhibition of RAR signaling in PTECs protects against experimental AKI but is associated with increased expression of the PTEC injury marker, Kim-1. However, Kim-1 is also expressed by de-differentiated, proliferating PTECs, and protects against injury by increasing apoptotic cell clearance, or efferocytosis. We show that the protective effect of inhibiting PTEC RAR signaling is mediated by increased Kim-1 dependent efferocytosis, and that this is associated with de-differentiation, proliferation, and metabolic reprogramming of PTECs. These data demonstrate a novel functional role that reactivation of RAR signaling plays in regulating PTEC differentiation and function in human and experimental AKI." @default.
- W4380738388 created "2023-06-16" @default.
- W4380738388 creator A5009531733 @default.
- W4380738388 creator A5027136611 @default.
- W4380738388 creator A5030279380 @default.
- W4380738388 creator A5033492490 @default.
- W4380738388 creator A5038084716 @default.
- W4380738388 creator A5042782798 @default.
- W4380738388 creator A5043315304 @default.
- W4380738388 creator A5046958803 @default.
- W4380738388 creator A5055614926 @default.
- W4380738388 creator A5058577869 @default.
- W4380738388 creator A5081514433 @default.
- W4380738388 creator A5083630980 @default.
- W4380738388 creator A5090425922 @default.
- W4380738388 creator A5092173549 @default.
- W4380738388 date "2023-06-15" @default.
- W4380738388 modified "2023-09-27" @default.
- W4380738388 title "Inhibition of Retinoic Acid Signaling in Proximal Tubular Epithelial cells Protects against Acute Kidney Injury by Enhancing Kim-1-dependent Efferocytosis" @default.
- W4380738388 cites W1744619657 @default.
- W4380738388 cites W1826889366 @default.
- W4380738388 cites W1845759512 @default.
- W4380738388 cites W1905476969 @default.
- W4380738388 cites W1964405385 @default.
- W4380738388 cites W1967712562 @default.
- W4380738388 cites W1970377223 @default.
- W4380738388 cites W1971271779 @default.
- W4380738388 cites W1983640477 @default.
- W4380738388 cites W1984495434 @default.
- W4380738388 cites W2005827807 @default.
- W4380738388 cites W2005883936 @default.
- W4380738388 cites W2006246095 @default.
- W4380738388 cites W2007281432 @default.
- W4380738388 cites W2007631412 @default.
- W4380738388 cites W2008864584 @default.
- W4380738388 cites W2011507807 @default.
- W4380738388 cites W2013863464 @default.
- W4380738388 cites W2029861821 @default.
- W4380738388 cites W2035618305 @default.
- W4380738388 cites W2039499065 @default.
- W4380738388 cites W2041736631 @default.
- W4380738388 cites W2041929136 @default.
- W4380738388 cites W2045421375 @default.
- W4380738388 cites W2068446361 @default.
- W4380738388 cites W2071441516 @default.
- W4380738388 cites W2072251462 @default.
- W4380738388 cites W2073625832 @default.
- W4380738388 cites W2075764855 @default.
- W4380738388 cites W2076268046 @default.
- W4380738388 cites W2084757192 @default.
- W4380738388 cites W2098070914 @default.
- W4380738388 cites W2098079184 @default.
- W4380738388 cites W2102556842 @default.
- W4380738388 cites W2103017472 @default.
- W4380738388 cites W2103313018 @default.
- W4380738388 cites W2114104545 @default.
- W4380738388 cites W2116748702 @default.
- W4380738388 cites W2119209688 @default.
- W4380738388 cites W2122008192 @default.
- W4380738388 cites W2136709241 @default.
- W4380738388 cites W2141478391 @default.
- W4380738388 cites W2145375514 @default.
- W4380738388 cites W2146368534 @default.
- W4380738388 cites W2146512944 @default.
- W4380738388 cites W2147901392 @default.
- W4380738388 cites W2147938157 @default.
- W4380738388 cites W2148969684 @default.
- W4380738388 cites W2153704460 @default.
- W4380738388 cites W2154450105 @default.
- W4380738388 cites W2195071417 @default.
- W4380738388 cites W2209250550 @default.
- W4380738388 cites W2234948637 @default.
- W4380738388 cites W2317708108 @default.
- W4380738388 cites W2343540188 @default.
- W4380738388 cites W2465492279 @default.
- W4380738388 cites W2735777297 @default.
- W4380738388 cites W2762301491 @default.
- W4380738388 cites W2765236814 @default.
- W4380738388 cites W2781080196 @default.
- W4380738388 cites W2790619575 @default.
- W4380738388 cites W2794866328 @default.
- W4380738388 cites W2806846414 @default.
- W4380738388 cites W2885653586 @default.
- W4380738388 cites W2888749427 @default.
- W4380738388 cites W2891706128 @default.
- W4380738388 cites W2896613080 @default.
- W4380738388 cites W2899136988 @default.
- W4380738388 cites W2914769565 @default.
- W4380738388 cites W2952220882 @default.
- W4380738388 cites W2953177296 @default.
- W4380738388 cites W2964601516 @default.
- W4380738388 cites W2968766541 @default.
- W4380738388 cites W2972713657 @default.
- W4380738388 cites W2977065915 @default.
- W4380738388 cites W2982656424 @default.
- W4380738388 cites W2985098178 @default.
- W4380738388 cites W2995149669 @default.
- W4380738388 cites W3015080429 @default.
- W4380738388 cites W3016576290 @default.
- W4380738388 cites W3017190624 @default.