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- W4380738532 abstract "Notch signaling is an evolutionarily conserved pathway for specifying binary neuronal fates, yet its mechanism remains elusive. In our accompanying paper, using the Drosophila lamina neuron types (L1-L5) as a model, we show that the homeodomain transcription factor (HDTF) Bsh specifies L4 and L5 fates. Here we test the hypothesis that Notch signaling enables Bsh to differentially specify L4 and L5 fates. We show asymmetric Notch signaling between newborn L4 and L5 neurons, but they are not siblings; rather, Notch signaling in L4 is due to Delta expression in adjacent L1 neurons. While Notch signaling and Bsh expression are mutually independent, Notch is necessary and sufficient for Bsh to specify L4 fate over L5. With Notch signaling, L4 generates a distinct open chromatin landscape which results in distinct Bsh genome-binding loci, leading to L4-specific gene transcription. We propose that Notch signaling and HDTF function are integrated to diversify neuronal types." @default.
- W4380738532 created "2023-06-16" @default.
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- W4380738532 date "2023-06-15" @default.
- W4380738532 modified "2023-09-24" @default.
- W4380738532 title "Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types" @default.
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- W4380738532 doi "https://doi.org/10.1101/2023.06.15.545141" @default.
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