FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380741616> ?p ?o ?g. }

• W4380741616 abstract "Abstract Ethylene signalling represents one of the classic hormonal pathways in plants, with diverse roles in development and stress responses. The dimeric ethylene receptor localizes to the endoplasmic reticulum (ER) and contains Cu(I) ions essential for ethylene binding and signalling. As for other vesicular cupro-proteins, the final step of Cu(I) maturation at the ER is undefined. We previously discovered that mutants in the Arabidopsis gene POLARIS ( PLS ), encoding a 36 amino acid peptide, exhibit constitutive ethylene signalling responses. Here we report a 1:2 thiol-dependent Cu(I):PLS 2 complex, with an affinity of 3.79 (±1.5) x10 19 M -2 . We demonstrate PLS interactions with the transmembrane domain of receptor protein ETR1, the Cu(I) chaperones ATX1 and CCH, and Cu(I)-transporting P 1B -type ATPase RAN1 at the ER. Formation of Cu(I)-dependent PLS- cuproprotein adducts at the ER provides a mechanism to modulate the metalation of ETR1, thereby regulating its activity and representing a novel mechanism for plant hormone receptor regulation. One Sentence Summary The POLARIS peptide of Arabidopsis regulates activity of the ethylene hormone receptor by controlling Cu(I) availability." @default.
• W4380741616 created "2023-06-16" @default.
• W4380741616 creator A5005288009 @default.
• W4380741616 creator A5006900868 @default.
• W4380741616 creator A5007299572 @default.
• W4380741616 creator A5007433152 @default.
• W4380741616 creator A5014172308 @default.
• W4380741616 creator A5017107880 @default.
• W4380741616 creator A5020343584 @default.
• W4380741616 creator A5021507772 @default.
• W4380741616 creator A5026093201 @default.
• W4380741616 creator A5058467039 @default.
• W4380741616 creator A5059831079 @default.
• W4380741616 creator A5073194199 @default.
• W4380741616 creator A5092174226 @default.
• W4380741616 date "2023-06-15" @default.
• W4380741616 modified "2023-09-27" @default.
• W4380741616 title "A peptide that regulates metalation and function of the<i>Arabidopsis</i>ethylene receptor" @default.
• W4380741616 cites W1600305299 @default.
• W4380741616 cites W1798853073 @default.
• W4380741616 cites W1968209620 @default.
• W4380741616 cites W1980099457 @default.
• W4380741616 cites W1986254730 @default.
• W4380741616 cites W1994848146 @default.
• W4380741616 cites W2012927918 @default.
• W4380741616 cites W2019207089 @default.
• W4380741616 cites W2020584700 @default.
• W4380741616 cites W2041312551 @default.
• W4380741616 cites W2051031541 @default.
• W4380741616 cites W2052126555 @default.
• W4380741616 cites W2054708511 @default.
• W4380741616 cites W2055326419 @default.
• W4380741616 cites W2067334188 @default.
• W4380741616 cites W2071883986 @default.
• W4380741616 cites W2078941883 @default.
• W4380741616 cites W2083364406 @default.
• W4380741616 cites W2100320558 @default.
• W4380741616 cites W2106748349 @default.
• W4380741616 cites W2108733083 @default.
• W4380741616 cites W2109610428 @default.
• W4380741616 cites W2116122104 @default.
• W4380741616 cites W2129862056 @default.
• W4380741616 cites W2134859485 @default.
• W4380741616 cites W2158628605 @default.
• W4380741616 cites W2168295659 @default.
• W4380741616 cites W2168517773 @default.
• W4380741616 cites W2170923595 @default.
• W4380741616 cites W2179438025 @default.
• W4380741616 cites W2604706868 @default.
• W4380741616 cites W2755720999 @default.
• W4380741616 cites W2795091386 @default.
• W4380741616 cites W2948833920 @default.
• W4380741616 cites W2950678250 @default.
• W4380741616 cites W2963895227 @default.
• W4380741616 cites W4361000942 @default.
• W4380741616 doi "https://doi.org/10.1101/2023.06.15.545071" @default.
• W4380741616 hasPublicationYear "2023" @default.
• W4380741616 type Work @default.
• W4380741616 citedByCount "0" @default.
• W4380741616 crossrefType "posted-content" @default.
• W4380741616 hasAuthorship W4380741616A5005288009 @default.
• W4380741616 hasAuthorship W4380741616A5006900868 @default.
• W4380741616 hasAuthorship W4380741616A5007299572 @default.
• W4380741616 hasAuthorship W4380741616A5007433152 @default.
• W4380741616 hasAuthorship W4380741616A5014172308 @default.
• W4380741616 hasAuthorship W4380741616A5017107880 @default.
• W4380741616 hasAuthorship W4380741616A5020343584 @default.
• W4380741616 hasAuthorship W4380741616A5021507772 @default.
• W4380741616 hasAuthorship W4380741616A5026093201 @default.
• W4380741616 hasAuthorship W4380741616A5058467039 @default.
• W4380741616 hasAuthorship W4380741616A5059831079 @default.
• W4380741616 hasAuthorship W4380741616A5073194199 @default.
• W4380741616 hasAuthorship W4380741616A5092174226 @default.
• W4380741616 hasBestOaLocation W43807416161 @default.
• W4380741616 hasConcept C104317684 @default.
• W4380741616 hasConcept C118892022 @default.
• W4380741616 hasConcept C143065580 @default.
• W4380741616 hasConcept C158617107 @default.
• W4380741616 hasConcept C161790260 @default.
• W4380741616 hasConcept C170493617 @default.
• W4380741616 hasConcept C185592680 @default.
• W4380741616 hasConcept C2775988993 @default.
• W4380741616 hasConcept C2778597550 @default.
• W4380741616 hasConcept C2779281246 @default.
• W4380741616 hasConcept C2779491563 @default.
• W4380741616 hasConcept C55493867 @default.
• W4380741616 hasConcept C86803240 @default.
• W4380741616 hasConcept C95444343 @default.
• W4380741616 hasConceptScore W4380741616C104317684 @default.
• W4380741616 hasConceptScore W4380741616C118892022 @default.
• W4380741616 hasConceptScore W4380741616C143065580 @default.
• W4380741616 hasConceptScore W4380741616C158617107 @default.
• W4380741616 hasConceptScore W4380741616C161790260 @default.
• W4380741616 hasConceptScore W4380741616C170493617 @default.
• W4380741616 hasConceptScore W4380741616C185592680 @default.
• W4380741616 hasConceptScore W4380741616C2775988993 @default.
• W4380741616 hasConceptScore W4380741616C2778597550 @default.
• W4380741616 hasConceptScore W4380741616C2779281246 @default.
• W4380741616 hasConceptScore W4380741616C2779491563 @default.
• W4380741616 hasConceptScore W4380741616C55493867 @default.

• next