Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380742110> ?p ?o ?g. }
- W4380742110 endingPage "106204" @default.
- W4380742110 startingPage "106204" @default.
- W4380742110 abstract "Listeria monocytogenes (Lm) is a deadly foodborne pathogen that comprises 14 serotypes, among which, serotype 4b Lm is the primary cause of listeriosis outbreaks in humans and animals. Here, we evaluated the safety, immunogenicity, and protective efficacy of a serotype 4b vaccine candidate Lm NTSNΔactA/plcB/orfX in sheep. The infection dynamics, clinical features, and pathological observation verified that the triple genes deletion strain has adequate safety for sheep. Moreover, NTSNΔactA/plcB/orfX significantly stimulated humoral immune response and provided 78% immune protection to sheep against lethal wild-type strain challenge. Notably, the attenuated vaccine candidate could differentiate infected and vaccinated animals (DIVA) via serology determination of the antibody against listeriolysin O (LLO, encoded by hly) and phosphatidylinositol-specific phospholipase C (PI-PLC, encoded by plcB). These data suggest that the serotype 4b vaccine candidate has high efficacy, safety, and DIVA characteristics, and may be used to prevent Lm infection in sheep. Our study provides a theoretical basis for its future application in livestock and poultry breeding." @default.
- W4380742110 created "2023-06-16" @default.
- W4380742110 creator A5002115486 @default.
- W4380742110 creator A5008295359 @default.
- W4380742110 creator A5037747759 @default.
- W4380742110 creator A5044797996 @default.
- W4380742110 creator A5050536898 @default.
- W4380742110 creator A5050837761 @default.
- W4380742110 creator A5055791807 @default.
- W4380742110 creator A5056248574 @default.
- W4380742110 creator A5061080282 @default.
- W4380742110 creator A5092174335 @default.
- W4380742110 creator A5092174336 @default.
- W4380742110 date "2023-08-01" @default.
- W4380742110 modified "2023-09-27" @default.
- W4380742110 title "A live attenuated DIVA vaccine affords protection against Listeria monocytogenes challenge in sheep" @default.
- W4380742110 cites W1966327293 @default.
- W4380742110 cites W1976279254 @default.
- W4380742110 cites W1997808956 @default.
- W4380742110 cites W2000307781 @default.
- W4380742110 cites W2039483287 @default.
- W4380742110 cites W2042876822 @default.
- W4380742110 cites W2047485767 @default.
- W4380742110 cites W2055498840 @default.
- W4380742110 cites W2057138015 @default.
- W4380742110 cites W2068540311 @default.
- W4380742110 cites W2092150161 @default.
- W4380742110 cites W2121320864 @default.
- W4380742110 cites W2127080156 @default.
- W4380742110 cites W2131714084 @default.
- W4380742110 cites W2149637506 @default.
- W4380742110 cites W2153464983 @default.
- W4380742110 cites W2153819354 @default.
- W4380742110 cites W2170577357 @default.
- W4380742110 cites W2261262439 @default.
- W4380742110 cites W2270883619 @default.
- W4380742110 cites W2287430341 @default.
- W4380742110 cites W2302269886 @default.
- W4380742110 cites W2605830273 @default.
- W4380742110 cites W2613127712 @default.
- W4380742110 cites W2624665019 @default.
- W4380742110 cites W2793447503 @default.
- W4380742110 cites W2808299269 @default.
- W4380742110 cites W2955241315 @default.
- W4380742110 cites W2995084770 @default.
- W4380742110 cites W3012033483 @default.
- W4380742110 cites W3111137866 @default.
- W4380742110 cites W3203522573 @default.
- W4380742110 doi "https://doi.org/10.1016/j.micpath.2023.106204" @default.
- W4380742110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37327947" @default.
- W4380742110 hasPublicationYear "2023" @default.
- W4380742110 type Work @default.
- W4380742110 citedByCount "0" @default.
- W4380742110 crossrefType "journal-article" @default.
- W4380742110 hasAuthorship W4380742110A5002115486 @default.
- W4380742110 hasAuthorship W4380742110A5008295359 @default.
- W4380742110 hasAuthorship W4380742110A5037747759 @default.
- W4380742110 hasAuthorship W4380742110A5044797996 @default.
- W4380742110 hasAuthorship W4380742110A5050536898 @default.
- W4380742110 hasAuthorship W4380742110A5050837761 @default.
- W4380742110 hasAuthorship W4380742110A5055791807 @default.
- W4380742110 hasAuthorship W4380742110A5056248574 @default.
- W4380742110 hasAuthorship W4380742110A5061080282 @default.
- W4380742110 hasAuthorship W4380742110A5092174335 @default.
- W4380742110 hasAuthorship W4380742110A5092174336 @default.
- W4380742110 hasConcept C10389963 @default.
- W4380742110 hasConcept C104317684 @default.
- W4380742110 hasConcept C116675565 @default.
- W4380742110 hasConcept C159047783 @default.
- W4380742110 hasConcept C203014093 @default.
- W4380742110 hasConcept C2780868878 @default.
- W4380742110 hasConcept C2781092335 @default.
- W4380742110 hasConcept C2781350384 @default.
- W4380742110 hasConcept C523546767 @default.
- W4380742110 hasConcept C54355233 @default.
- W4380742110 hasConcept C54602769 @default.
- W4380742110 hasConcept C60987743 @default.
- W4380742110 hasConcept C86803240 @default.
- W4380742110 hasConcept C8891405 @default.
- W4380742110 hasConcept C89423630 @default.
- W4380742110 hasConceptScore W4380742110C10389963 @default.
- W4380742110 hasConceptScore W4380742110C104317684 @default.
- W4380742110 hasConceptScore W4380742110C116675565 @default.
- W4380742110 hasConceptScore W4380742110C159047783 @default.
- W4380742110 hasConceptScore W4380742110C203014093 @default.
- W4380742110 hasConceptScore W4380742110C2780868878 @default.
- W4380742110 hasConceptScore W4380742110C2781092335 @default.
- W4380742110 hasConceptScore W4380742110C2781350384 @default.
- W4380742110 hasConceptScore W4380742110C523546767 @default.
- W4380742110 hasConceptScore W4380742110C54355233 @default.
- W4380742110 hasConceptScore W4380742110C54602769 @default.
- W4380742110 hasConceptScore W4380742110C60987743 @default.
- W4380742110 hasConceptScore W4380742110C86803240 @default.
- W4380742110 hasConceptScore W4380742110C8891405 @default.
- W4380742110 hasConceptScore W4380742110C89423630 @default.
- W4380742110 hasLocation W43807421101 @default.
- W4380742110 hasLocation W43807421102 @default.
- W4380742110 hasOpenAccess W4380742110 @default.